Results 111 to 120 of about 56,016 (216)

Clinical pharmacokinetics and metabolism of irinotecan (CPT-11) [PDF]

, 2001
CPT-11 belongs to the class of topoisomerase I inhibitors, and it acts as a prodrug of SN-38, which is approximately 100-1000-fold more cytotoxic than the parent drug.
Alphen, R.J. (Robbert) van, Loos, W.J. (Walter), Mathijssen, A.H.J. (Ron), Nooter, K. (Kees), Sparreboom, A. (Alex), Stoter, G. (Gerrit), Verweij, J. (Jaap)   +6 more
core  

In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling [PDF]

, 2017
Estragole is a naturally occurring food-borne genotoxic compound found in a variety of food sources, including spices and herbs. This results in human exposure to estragole via the regular diet.
Alink, Gerrit, Gremaud, Eric, Paini, Alicia, Punt, Ans, Rietjens, Ivonne M.C.M., Schilter, Benoît, Scholz, Gabriele, Spenkelink, Bert, van Bladeren, Peter J.   +8 more
core  

Utilization of carbon catabolite repression for efficiently biotransformation of anthraquinone O-glucuronides by Streptomyces coeruleorubidus DM

Frontiers in Microbiology
Carbon catabolite repression (CCR) is a highly conserved mechanism that regulates carbon source utilization in Streptomyces. CCR has a negative impact on secondary metabolite fermentation, both in industrial and research settings.
Chen Tao, Quyi Wang, Junyang Ji, Ziyue Zhou, Bingjie Yue, Ran Zhang, Shu Jiang, Shu Jiang, Tianjie Yuan   +8 more
doaj   +1 more source

glucuronide

Citation: 'glucuronide' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09798 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

STRATEGY FOR ASSESSING IMPACTS OF THYROID DISRUPTING CHEMICALS IN TELEOSTEANS [PDF]

, 2011
Peer ...
Blust, Ronny, Celis, Niko, Covaci, Adrian, Das, Krishna, Dirtu, Alin, Klaren, Peter, Schnitzler, Joseph, Silvestre, Frédéric   +7 more
core  

Modulation of irinotecan-induced diarrhea by cotreatment with neomycin in cancer patients [PDF]

, 2001
This study was designed to evaluate irinotecan (CPT-11) disposition and pharmacodynamics in the presence and absence of the broad-spectrum antibiotic neomycin.
Bruijn, P.J. (Peter) de, Jonge, M.J.A. (Maja) de, Kehrer, D.F.S. (Diederik), Nierop, C.A., Ruijgrok, E.J. (Elisabeth), Schraaf, J. van de, Sparreboom, A. (Alex), Verweij, J. (Jaap)   +7 more
core  

In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography [PDF]

, 2003
Background and aims: Positron emission tomography (PET) using 18F labelled 2-fluoro-2-deoxy-D-glucose (18FDG) is an established imaging tool, although the recent development of a biologically stable thymidine analogue [18F] 3'-deoxy-3-fluorothymidine ...
Costa, D.C., Ell, P.J., Francis, D.L., Freeman, A., Luthra, S.K., Novelli, M., Taylor, I., Visvikis, D.   +7 more
core  

Prescription of paracetamol-containing medications as indicator of quality of prescribing [PDF]

, 2007
Batty, Gwenno M., Grant, Robert R., Jackson, Stephen H. D., Lowe, Derek, Manyemba, Juliet, Pearson, Michael G., Potter, Jonathan M.   +6 more
core   +1 more source

Glucuronide [PDF]

, 2020
openaire   +1 more source

Genetic influences on individual differences in nicotine glucuronidation [PDF]

, 2009
Benowitz, Neal L, Jacob, Peyton, III, Lessov-Schlaggar, Christina N, Swan, Gary E   +3 more
core   +2 more sources