Factors Affecting the Relationship Between Total and Unbound Bilirubin in Preterm and Term Infants
Acta Paediatrica, Volume 114, Issue 8, Page 1977-1981, August 2025.ABSTRACT Aim Newborn infants universally experience jaundice, most of which is physiologic, but in some high‐risk situations, it may lead to neurological dysfunction or death. Unbound bilirubin (Bf) may be the best predictor of bilirubin toxicity in this population. The goal of the study is to examine the relationship between total serum bilirubin (TSB)
Thomas Hegyi +6 more
wiley +1 more source
Clinical and Translational Science, Volume 18, Issue 8, August 2025.ABSTRACT Bocidelpar is a peroxisome proliferator‐activated receptor δ modulator designed to address mitochondrial impairment. Two open‐label, single‐dose phase 1 studies (NCT05117294/NCT04942964) investigated the effect of severe renal or mild/moderate hepatic impairment on bocidelpar pharmacokinetics and safety.
Megumi Iwai +10 more
wiley +1 more source
Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate
Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.ABSTRACT Chronic kidney disease (CKD) affects over 10% of the world's population and is associated with high morbidity and mortality rates. The management of CKD is complex; CKD alters drug pharmacokinetics and pharmacodynamics and further complicates therapeutic strategies regimens.
Sophie Liabeuf +6 more
wiley +1 more source
Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver [PDF]
, 1999 Hiroshi Yokota +6 more
openalex +1 more source
Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo +9 more
wiley +1 more source
Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides [PDF]
, 1999 Marco Ciotti +5 more
openalex +1 more source
Glucuronidation and sulphation of paracetamol in HIV‐positive patients and patients with AIDS [PDF]
, 1999 O’Neil +4 more
openalex +1 more source
Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved [PDF]
, 1999 Susan Nowell
openalex +1 more source