Results 11 to 20 of about 39,652 (331)
Caution with PBPK Modeling Based on the In Vitro Kinetics for Bilirubin Hepatic Uptake and Glucuronidation: Commentary on Dong et al. [PDF]
Clin Pharmacol TherClinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 301-303, August 2025.
Miners JO, Polasek TM.
europepmc +2 more sources
Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac [PDF]
MoleculesBackground: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro. Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver,
Eric Asare +5 more
doaj +2 more sources
Species Differences in Ezetimibe Glucuronidation [PDF]
MetabolitesBackground: Peclinical and clinical studies have revealed that ezetimibe, an approved cholesterol-absorption inhibitor, is rapidly and extensively metabolized to a more potent metabolite, ezetimibe glucuronide.
Shalom Emmanuel +5 more
doaj +2 more sources
Utilization of carbon catabolite repression for efficiently biotransformation of anthraquinone O-glucuronides by Streptomyces coeruleorubidus DM [PDF]
Frontiers in MicrobiologyCarbon catabolite repression (CCR) is a highly conserved mechanism that regulates carbon source utilization in Streptomyces. CCR has a negative impact on secondary metabolite fermentation, both in industrial and research settings.
Chen Tao +8 more
doaj +2 more sources
The Journal of pharmacy and pharmacology, 2020 Ginkgo biloba leaves contain amentoflavone (AMF), a dietary flavonoid that possesses antioxidant and anticancer activity. Flavonoids are extensively subjected to glucuronidation.
Lili Gan +11 more
semanticscholar +1 more source
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2012 Alcohol is associated with significant morbidity and mortality. Subjects abusing alcohol can be identified through clinical history, examination or self-report questionnaires. A range of biomarkers is available for detecting alcohol misuse, but there is still a need for a marker that can detect alcohol consumption in the time window between one day ...
Walsham, Natalie E., Sherwood, Roy
openaire +3 more sources
Animals, 2022 UDP-glucuronosyltransferases (UGTs) are one of the most important enzymes for xenobiotic metabolism or detoxification. Through duplication and loss of genes, mammals evolved the species-specific variety of UGT isoforms. Among mammals, Carnivora is one of
Mitsuki Kondo +4 more
doaj +1 more source
Metabolites, 2022 This study aimed to understand the mechanisms underlying the effects of maternal undernutrition (MUN) on liver growth and metabolism in Japanese Black fetal calves (8.5 months in utero) using an approach that integrates metabolomics and transcriptomics ...
Susumu Muroya +8 more
doaj +1 more source
Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-group Prospective Cohort Study in two sub-Saharan Africa Populations. [PDF]
, 2013 We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two African populations. ART naïve HIV patients from Ethiopia (n = 285) and Tanzania (n = 209)
A Habtewold +48 more
core +11 more sources
Potential Assessment of UGT2B17 Inhibition by Salicylic Acid in Human Supersomes In Vitro
Molecules, 2021 Glucuronidation is a Phase 2 metabolic pathway responsible for the metabolism and excretion of testosterone to a conjugate testosterone glucuronide.
Hassan Salhab +2 more
doaj +1 more source