In vivo metabolism of ibuprofen in growing conventional pigs : a pharmacokinetic approach [PDF]
, 2019 The juvenile conventional pig has been suggested as a preclinical animal model to evaluate pharmacokinetic (PK), pharmacodynamic (PD), and safety parameters in children. However, a lot of developmental changes in pig physiology still need to be unraveled.
Croubels, Siska +3 more
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Journal of Lipid Research, 2014 The compound 20-HETE is involved in numerous physiological functions, including blood pressure and platelet aggregation. Glucuronidation of 20-HETE by UDP-glucuronosyltransferases (UGTs) is thought to be a primary pathway of 20-HETE elimination in humans.
Yazun Bashir Jarrar +7 more
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Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]
, 2019 Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe +9 more
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Effects of thyroid status and thyrostatic drugs on hepatic glucuronidation of lodothyronines and other substrates in rats - Induction of phenol UDP-glucuronyltransferase by methimazole [PDF]
, 1995 Glucuronidation of iodothyronines in rat liver is catalyzed by at least three UDP-glucuronyltransferases (UGTs): bilirubin UGT, phenol UGT, and androsterone UGT.
Bonthuis, F. (Fred) +6 more
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Multi-Omics in Predicting Lamotrigine Neurotoxicity: Current Opportunities (Review)
Безопасность и риск фармакотерапии, 2022 INTRODUCTION. Lamotrigine (LTG) is among the most commonly prescribed second-generation antiepileptic drugs due to its low teratogenic risk. However, lamotrigine has pronounced neurotoxic, hepatotoxic, dermatotoxic potential (for genetic and metabolic ...
N. A. Shnayder +3 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2018 Purpose: The chemotherapeutic agent irinotecan is hydrolyzed to its active form SN-38 by human carboxyesterases, but SN-38 is converted into the inactive form SN-38G by hepatic UDP-glucuronosyltransferases (UGTs).
Takashi Satoh +5 more
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Morphine Metabolism in Human Skin Microsomes [PDF]
, 2012 For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S. +2 more
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Journal of Lipid Research, 1988 Microsomal preparations from livers of Sprague-Dawley rats catalyze the glucuronidation of 3 alpha-hydroxy-5 beta-H (3 alpha, 5 beta) short-chain bile acids (C20-C23), predominantly at the hydroxyl group, while the glucuronidation of 3 beta, 5 beta short-
A Radominska +4 more
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UGT2B7 c.-161C>T polymorphism frequency in Croatian population
Arhiv za Higijenu Rada i Toksikologiju, 2022 Uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7), enzyme responsible for the elimination of a number of xenobiotics through glucuronidation, is expressed in the gut, kidneys, intestines, and brain.
Božina Tamara +6 more
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Bisphenol-A and phthalate metabolism in children with neurodevelopmental disorders.
PLoS ONE, 2023 BackgroundThe etiology of autism spectrum (ASD) and Attention Deficit/Hyperactivity (ADHD) disorders are multifactorial. Epidemiological studies have shown associations with environmental pollutants, such as plasticizers.
T Peter Stein +3 more
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