Results 31 to 40 of about 56,016 (216)

Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases [PDF]

, 2014
Bavachalcone and corylin are two major bioactive compounds isolated from Psoralea corylifolia L., which has been widely used as traditional Chinese medicine for many years.
Feng, Yujun, Qiu, Zhenyu, Shan, Lina, Shi, Xianbao, Tian, Lei, Yang, Shuman, Yuan, Hongxia, Zhang, Gang, Zhou, Dun   +8 more
core   +4 more sources

The Evaluation of Genetic Profiles of UGT1A4 and UGT1A6 in the Turkish Population

Journal of Contemporary Medicine, 2021
Aim: Uridine diphosphate glucuronosyltransferases (UGTs) are a superfamily of conjugation phase II enzymes and is responsible for catalyzing the glucuronidation of many endobiotic or xenobiotic substrates.
Zuhal Uçkun Şahinoğulları
doaj   +1 more source

Red wine and components flavonoids inhibit UGT2B17 in vitro [PDF]

, 2012
Background The metabolism and excretion of the anabolic steroid testosterone occurs by glucuronidation to the conjugate testosterone glucuronide which is then excreted in urine.
A Barata, A Juul, A Morgentaler, A Seemungal, AA Alomary, AL Waterhouse, Andrea Petroczi, AP Pollnitz, B Djavan, B Tariba, C Chao, C Jenkinson, C Swanson, Carl Jenkinson, CF Ferris, D Turgeon, Declan P Naughton, ET Eng, H Chiyang, HM Behre, J Jakobsson, J Key, JA Conquer, L Ekstrom, L Ekström, NS Wong, P Simonetti, R Rodrigo, S Egert, S He, S Sutcliffe, S Walorczyk, T Imamoto, T Magrone, T Sten, TL Yang   +35 more
core   +2 more sources

Biosynthesis of hydroxyl-linked glucuronides of short-chain bile acids by rat liver 3-hydroxysteroid UDP-glucuronosyltransferase.

Journal of Lipid Research, 1988
Microsomal preparations from livers of Sprague-Dawley rats catalyze the glucuronidation of 3 alpha-hydroxy-5 beta-H (3 alpha, 5 beta) short-chain bile acids (C20-C23), predominantly at the hydroxyl group, while the glucuronidation of 3 beta, 5 beta short-
A Radominska, M D Green, P Zimniak, R Lester, T R Tephly   +4 more
doaj   +1 more source

Metabolism and toxicity of two new benzodiazepine-type antileishmanial agents in hepatocytes and macrophages [PDF]

, 2007
With increasing reports of resistance of Leishmania to antimonials (Thakur et al., 2004) and other traditional antileishmanial drugs, the need for the discovery of new antileishmanial agents is rising.
Clarke, R., Duong Thi, M.D., Grant, M.H., Mackay, S.P., Mullen, A.B., Tettey, J.N.A.   +5 more
core   +1 more source

Implication of human UGT2B7, 2B15 and 2B17 in 19-norandrosterone metabolism

Frontiers in Endocrinology, 2013
Nandrolone (19-nortestosterone) is an anabolic androgenic steroid commonly abused for doping purposes. Nandrolone is mainly metabolized in the liver into 19-norandrosterone prior to glucuronidation and excretion through urine over an extended period of ...
Emmanuel eStrahm, Ulf eSjöberg, Mats eGarle, Anders eRane, Lena eEkström   +4 more
doaj   +1 more source

In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential. [PDF]

Rapid Commun Mass Spectrom
ABSTRACT Rationale Estrogen‐related receptor (ERR) agonists such as the drug candidates SLU‐PP‐332 and SLU‐PP‐915 are currently being investigated as exercise mimetics, given their ability to trigger human physiological processes similar to those initiated by actual physical activity.
Möller T, Krug O, Thevis M.
europepmc   +2 more sources

Glucuronidation: driving factors and their impact on glucuronide disposition

Drug Metabolism Reviews, 2017
Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals including drugs and endogenous substances. Although it is usually the secondary metabolic pathway for a compound preceded by phase I hydroxylation, glucuronidation alone could serve as the dominant metabolic pathway for many compounds, including some with high ...
Guangyi, Yang, Shufan, Ge, Rashim, Singh, Sumit, Basu, Katherine, Shatzer, Ming, Zen, Jiong, Liu, Yifan, Tu, Chenning, Zhang, Jinbao, Wei, Jian, Shi, Lijun, Zhu, Zhongqiu, Liu, Yuan, Wang, Song, Gao, Ming, Hu   +15 more
openaire   +3 more sources

The pharmacokinetics of anthocyanins and their metabolites in humans [PDF]

, 2014
Background and Purpose: Anthocyanins are phytochemicals with reported vasoactive bioactivity. However, given their instability at neutral pH, they are presumed to undergo significant degradation and subsequent biotransformation.
Anupongsanugool, Azzini, Bell, Cardona, Cassidy, Cassidy, Czank, Das, Del Rio, Erdman, Ferrars, Forester, Garcia-Alonso, Gonzalez-Barrio, Ichiyanagi, Kay, Kay, Kay, Kim, Kim, Kim, Manach, McGhie, Min, Mink, Miyazawa, Mullen, Nardini, Nardini, Nizamutdinova, Nurmi, Pero, Rodriguez-Mateos, Stalmach, Toromanović, Vane, Vitaglione, Wang, Williamson, Wittemer, Woodward, Woodward, Xu, Zhang, Zhang, Zhang, Zhu   +46 more
core   +1 more source

Polyphenol‐Based Biomaterials Against Cancer Radio/Chemotherapy‐Induced Intestinal Toxicity

Advanced NanoBiomed Research, EarlyView.
Radiotherapy/chemotherapy often causes intestinal toxicity, impairing cancer patients’ quality of life and treatment efficacy. Polyphenols protect against this injury via multiple mechanisms, but face oral use limitations. This review outlines their protective mechanisms and delivery challenges, highlighting recent oral delivery advances and future ...
Jixu Lu, Jing Chen, Ji Zhu, Lixin Ru, Dongxiao Zhang   +4 more
wiley   +1 more source