Results 71 to 80 of about 57,722 (254)
Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. [PDF]
, 2013 BackgroundBisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid
Bradman, Asa +6 more
core +1 more source
British Journal of Pharmacology, EarlyView.Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert +13 more
wiley +1 more source
Frontiers in Oncology, 2019 High expression of the metabolic enzyme UDP-glucuronosyltransferase UGT2B17 in chronic lymphocytic leukemia (CLL) cells was associated with poor prognosis in two independent studies. However, the underlying mechanism remains unknown. We hypothesized that
Eric P. Allain +9 more
doaj +1 more source
Detoxification of 1,2-dihydroxy- 4-allylbenzene, a major phenolic compound in Piper betle, through glucuronidation using S9 protein of rat liver (Sprague Dawley) [PDF]
Pharmaciana, 2018 1,2-dihydroxy- 4-allylbenzene (DHAB) is a major compound in Piper betle leaf and also a metabolite of safrole metabolism. Epidemilogic studies showed people who have betel quid chewing habit are related to the incidence of oral submucous fibrosis and/or ...
Erryana Martati
doaj +1 more source
Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum
Plant Biotechnology Journal, EarlyView.ABSTRACT Diosgenin is a key starting material for the synthesis of steroidal drugs, such as corticosteroids and sex hormones. While the primary commercial source of diosgenin is the tubers of Dioscorea spp., identifying alternative plant hosts capable of diosgenin biosynthesis could enhance its production.
Jongbu Lim +16 more
wiley +1 more source
Antiepileptic Drug Disposition in Pregnancy
Pediatric Neurology Briefs, 2013 Investigators at the Karolinska Institute, Stockholm, Sweden; and centers in Oslo, Norway, and Milan, Italy, reviewed the literature on gestational effects on pharmacokinetics of older and newer antiepileptic drugs (AEDs).
J Gordon Millichap
doaj +1 more source
Influence of OATP1B1 Function on the Disposition of Sorafenib-β-D-Glucuronide [PDF]
, 2017 The oral multikinase inhibitor sorafenib undergoes extensive UGT1A9-mediated formation of sorafenib-β-D-glucuronide (SG). Using transporter-deficient mouse models, it was previously established that SG can be extruded into bile by ABCC2 or follow a liver-
Baker, S.D. +13 more
core +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 445-456, February 2026.Aims Pharmacogenetic implementation requires awareness of the state‐of‐the‐art practice of laboratories providing pharmacogenetic testing. This study investigated how pharmacogenetic guidelines and recommendations have been implemented over time by Italian laboratories participating in the external quality assessment (EQA) Pharmaco‐scheme established ...
Rossana Roncato +8 more
wiley +1 more source
In vitro glucuronidation of trans-Piceid and trans-Piceatannol by human liver microsomes
OENO One, 2008 Aims : The aim of the present investigation was to establish glucuronidation of trans-resveratrol derivates in the liver. Stilbenes are naturally occurring polyphenolic compounds which have been reported to have potential preventive activities in human ...
Caroline Henry-Vitrac +5 more
doaj +1 more source