Results 71 to 80 of about 25,845 (281)

Biosynthesis of imipramine glucuronide and characterization of imipramine glucuronidation catalyzed by recombinant UGT1A41 [PDF]

Acta Pharmacologica Sinica, 2006
To study the profile of imipramine N+-glucuronidation using homogenates of recombinant uridine-5'-diphosphoglucuronosyltransferase 1A4 (UGT1A4) from baculovirus-infected sf9 cells.Recombinant UGT1A4 was obtained from sf9 cells infected with recombinant baculovirus. Imipramine N(+)-glucuronide was biosynthesized by incubating imipramine with recombinant
Ming-rong Qian, Su Zeng
openaire   +3 more sources

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4

Scientific Reports, 2015
Glucuronidation mediated by uridine 5′-diphospho (UDP)-glucuronosyltransferase is an important detoxification pathway. However, identifying a selective probe of UDP- glucuronosyltransferase is complicated because of the significant overlapping substrate ...
Li Jiang, S. Liang, Chao Wang, Guangbo Ge, Xiaokui Huo, Xiao-yi Qi, S. Deng, Kexin Liu, Xiaochi Ma   +8 more
semanticscholar   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

In vitro glucuronidation of trans-Piceid and trans-Piceatannol by human liver microsomes

OENO One, 2008
Aims : The aim of the present investigation was to establish glucuronidation of trans-resveratrol derivates in the liver. Stilbenes are naturally occurring polyphenolic compounds which have been reported to have potential preventive activities in human ...
Caroline Henry-Vitrac, Thomas Richard, Alexis Desmoulière, Jean-Pierre Monti, Jean-Michel Mérillon, Stéphanie Krisa   +5 more
doaj   +1 more source

The sonic hedgehog factor Gli1 imparts drug resistance through inducible glucuronidation

Nature, 2014
Drug resistance is a major hurdle in oncology. Responses of acute myeloid leukaemia (AML) patients to cytarabine (Ara-C)-based therapies are often short lived with a median overall survival of months.
H. Zahreddine, B. Culjkovic-Kraljacic, S. Assouline, Patrick Gendron, A. Romeo, S. Morris, G. Cormack, James B. Jaquith, L. Cerchietti, E. Cocolakis, A. Amri, J. Bergeron, B. Leber, M. Becker, Shanshan Pei, C. Jordan, W. Miller, K. Borden   +17 more
semanticscholar   +1 more source

Population Pharmacokinetics and Exposure–Response Relationships of Maribavir in Transplant Recipients With First Episode or Refractory Cytomegalovirus

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Maribavir's anti‐cytomegalovirus (CMV) activity and favorable safety/tolerability profile is a welcomed addition to the CMV treatment armamentarium. To further characterize pharmacokinetic (PK) and exposure–response relationships of maribavir in transplant recipients with CMV, a population PK model was updated with data from the AURORA study ...
Kefeng Sun, Claudia Jomphe, Nathalie H. Gosselin, Leon Pheng, Chandrasekar Durairaj, Yaming Hang, Indranil Bhattacharya   +6 more
wiley   +1 more source

Apalutamide-induced severe hypothyroidism: case series and practice recommendations for thyroid management

European Thyroid Journal
The androgen receptor signaling inhibitor apalutamide is used successfully for the treatment of prostate cancer. An increased risk of hypothyroidism, mostly subclinical, has been reported in the SPARTAN and TITAN trials.
Karel David, Paul Van Crombrugge, Anne-Marie Van der Biest, Frederiek D’Hondt, Frank Claessens, Alexander Giesen, Steven Joniau, Brigitte Decallonne   +7 more
doaj   +1 more source

The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors

Frontiers in Pharmacology, 2019
Fraxetin, a natural compound present in many dietary supplements and herbs, is useful in the treatment of acute bacillary dysentery and type 2 diabetes. Previously, several metabolic studies have revealed extensive first-pass metabolism causing formation
Zifei Qin, Zifei Qin, Beibei Zhang, Beibei Zhang, Jing Yang, Jing Yang, Shishi Li, Jinjin Xu, Zhihong Yao, Zhihong Yao, Xiaojian Zhang, Xiaojian Zhang, Frank J. Gonzalez, Xinsheng Yao, Xinsheng Yao   +14 more
doaj   +1 more source

Upregulation of ST3GAL5 predicts suppression of malignant biological behavior in bladder cancer

UroPrecision, EarlyView.
Abstract Background Bladder cancer (BLCA) is the most prevalent malignancy in the urinary tract system, while ST3GAL5 is a protein‐coding gene that catalyzes the formation of ganglioside monosialodihexosylganglioside 3 (GM3) synthase. GM3 synthase has been reported to significantly influence the malignant process of various cancers.
Song Ou‐Yang, Lei Tang, Lin Li, Yawei Zhao   +3 more
wiley   +1 more source