Results 31 to 40 of about 30,656 (311)

A novel glucuronosyltransferase has an unprecedented ability to catalyse continuous two‐step glucuronosylation of glycyrrhetinic acid to yield glycyrrhizin

New Phytologist, 2016
Summary Glycyrrhizin is an important bioactive compound that is used clinically to treat chronic hepatitis and is also used as a sweetener world‐wide.
Guojie Xu, Wei Cai, Wei Gao, Chunsheng Liu   +3 more
semanticscholar   +1 more source

Effects of dietary components on testosterone metabolism via UDP‐glucuronosyltransferase (UGT)

Frontiers in Endocrinology, 2013
The potential interference in testosterone metabolism through ingested substances has ramifications for: i) a range of pathologies such as prostate cancer, ii) medication contra-indications, iii) disruption to the endocrine system, and iv) potential ...
Carl eJenkinson, Andrea ePetroczi, Declan P Naughton   +2 more
doaj   +1 more source

Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases

Antioxidants, 2021
2,3-Dehydrosilybin A and 2,3-dehydrosilybin B are a pair of enantiomers formed by the oxidation of the natural flavonolignans silybin A and silybin B, respectively.
Jiří Vrba, Barbora Papoušková, Kateřina Lněničková, Pavel Kosina, Vladimír Křen, Jitka Ulrichová   +5 more
doaj   +1 more source

Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice. [PDF]

, 2017
Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues.
Brenner, Stefan, Böhmdorfer, Michaela, Jäger, Walter, Riha, Juliane, Schiestl, Robert H, Szakmary, Akos, Szekeres, Thomas, Thalhammer, Theresia, Vaquero, Javier   +8 more
core   +2 more sources

Population pharmacokinetics and dosing of dispersible moxifloxacin formulation in children with rifampicin‐resistant tuberculosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Moxifloxacin is a priority drug for treating rifampicin‐resistant tuberculosis (RR‐TB). We assessed the pharmacokinetics of a child‐friendly, dispersible 100 mg tablet moxifloxacin formulation (dispersed in water) compared to the standard 400 mg non‐dispersible formulation (crushed and suspended in water) in children and evaluated current dosing ...
Megan Palmer, Yuanxi Zou, Anneke C. Hesseling, Louvina van der Laan, Ingrid Courtney, Aarti A. Kinikar, Naresh Sonkawade, Mandar Paradkar, Vandana Kulkarni, Dessa Jean O. Casalme, Melchor V. G. Frias, Heather Draper, Lubbe Wiesner, Mats O. Karlsson, Paolo Denti, Elin M. Svensson, Anthony J. Garcia‐Prats   +16 more
wiley   +2 more sources

Polymorphic expression of UDP-glucuronosyltransferase UGTlA gene in human colorectal cancer. [PDF]

PLoS ONE, 2013
BACKGROUND: Polymorphism of genes encoding drug-metabolizing enzymes is known to play an important role in increased susceptibility of colorectal cancer. UGT1A gene locus has been suggested to define tissue-specific glucuronidation activity.
Min Wang, De-Feng Sun, Shuai Wang, Ying Qing, Shuo Chen, Dong Wu, Ying-Min Lin, Ji-Zhuang Luo, Yan-Qing Li   +8 more
doaj   +1 more source

Targeting crosstalk between Nrf-2, NF-κB and androgen receptor signaling in prostate cancer [PDF]

, 2018
Oxidative stress, inflammation and androgen receptor (AR) signaling play a pivotal role in the initiation, development and progression of prostate cancer (PCa).
Khurana, Namrata, Sikka, Suresh C
core   +2 more sources

Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study. [PDF]

, 2013
BACKGROUND: We have previously shown that a functional polymorphism of the UGT2B15 gene (rs1902023) was associated with increased risk of prostate cancer (PC).
Freedland, SJ, Grant, DJ, Hoyo, C, McPhail, M, Richardson, RM, Schildkraut, JM, Tucker, C, Vidal, AC   +7 more
core   +2 more sources

Hematologically important mutations: bilirubin UDP-glucuronosyltransferase gene mutations in Gilbert and Crigler-Najjar syndromes. [PDF]

, 2005
Gilbert and Crigler-Najjar syndromes are familial unconjugated hyperbilirubinemias caused by genetic lesions involving a single complex locus encoding for bilirubin UDP-glucuronosyltransferase (UGT1A1) gene.
Costa, Elísio
core   +1 more source

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.

Journal of Clinical Oncology, 2004
PURPOSE Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38.
F. Innocenti, S. Undevia, L. Iyer, Peixian Chen, Soma Das, M. Kocherginsky, T. Karrison, L. Janisch, J. Ramírez, C. Rudin, E. Vokes, M. Ratain   +11 more
semanticscholar   +1 more source