Results 1 to 10 of about 7,531 (182)

Expanding the clinical and genetic spectrum of GLUL-related developmental and epileptic encephalopathy [PDF]

Scientific Reports
The GLUL gene encodes glutamine synthetase (GS), which plays a crucial role in glutamine–glutamate homeostasis. Both loss-of-function and gain-of-function variants of GLUL are known to cause genetic disorders in humans.
Dong Eon Oh, Se Song Jang, Woo Joong Kim, Soo Yeon Kim, Byung Chan Lim, Ki Joong Kim, Seungbok Lee, Jong-Hee Chae   +7 more
doaj   +7 more sources

Male proband with intractable seizures and a de novo start-codon-disrupting variant in GLUL [PDF]

HGG Advances
Summary: Bi-allelic variants in GLUL, encoding glutamine synthetase and responsible for the conversion of glutamate to glutamine, are associated with a severe recessive disease due to glutamine deficiency.
Elizabeth Carbonell, Sarah L. Stenton, Vijay S. Ganesh, Jialan Ma, Grace E. VanNoy, Lynn Pais, John N. Gaitanis, Melanie C. O’Leary, Heidi L. Rehm, Anne O’Donnell-Luria   +9 more
doaj   +6 more sources

GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

Acta Pharmaceutica Sinica B, 2023
Glutamate-ammonia ligase (GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation.
Qiwei Jiang, Yong Li, Songwang Cai, Xingyuan Shi, Yang Yang, Zihao Xing, Zhenjie He, Shengte Wang, Yubin Su, Meiwan Chen, Zhesheng Chen, Zhi Shi   +11 more
doaj   +5 more sources

Immunohistochemical localisation of Glutamate ammonia ligase (GLUL) in cerebrum in different clinical forms of canine rabies [PDF]

Journal of Veterinary and Animal Sciences, 2023
Rabies, one of the earliest known diseases reported in the history of mankind, is a fatal acute viral disease of the central nervous system. Despite numerous studies on etiology of rabies, its exact mechanism of neuropathogenesis remains unidentified ...
P. Nikhithasree , C. Divya, M.L. Arya Nair, K. Krithiga, K.S. Prasanna , Lali F. Anand, John Bernet Johnson   +6 more
doaj   +4 more sources

GLUL gene knockdown and restricted glucose level show synergistic inhibitory effect on the luminal subtype breast cancer MCF7 cells’ proliferation and metastasis [PDF]

EXCLI Journal : Experimental and Clinical Sciences, 2023
The glutamine synthetase path is one of the most important metabolic pathways in luminal breast cancer cells, which plays a critical role in supplying glutamine as an intermediate in the biosynthesis of amino acids and nucleotides.
Arezu Karimpur Zahmatkesh, Mohammad Khalaj-Kondori, Mohammad Ali Hosseinpour Feizi, Behzad Baradaran   +3 more
doaj   +5 more sources

GLUL rs10911021 polymorphism and risk of coronary artery disease among Egyptian individuals [PDF]

Bulletin of the National Research Centre, 2019
Background Genome-wide association studies have identified novel genes related to coronary artery disease (CAD). These studies have been replicated in distinct ethnic populations, returning inconsistent results. Our work aimed to study the frequency of C
Rasha Nazih Yousef, Solaf Ahmed Kamel, Nehal Salah Hasan, Mona Awad, Hesham Gamal, Nevine Ibrahim Musa, Mona Hamed Farag   +6 more
doaj   +5 more sources

LncRNA OIP5-AS1 Knockdown Targets miR-183-5p/GLUL Axis and Inhibits Cell Proliferation, Migration and Metastasis in Nasopharyngeal Carcinoma

Frontiers in Oncology, 2022
Nasopharyngeal carcinoma (NPC) is often associated with the infection of Epstein-Barr virus in nasopharynx and is mainly happened in South China and Southeast Asia. Recently, noncoding RNAs have been reported to regulate NPC carcinogenesis.
Shuo Li, Shuo Li, Mingxing Tang, Nan Zen, Nan Zen, Junyi Liang, Junyi Liang, Xiao Xing, Xiao Xing, Danglin Huang, Danglin Huang, Fei Liu, Fei Liu, Xiaomeng Zhang   +13 more
doaj   +5 more sources

GLUL mediates FOXO3 O-GlcNAcylation to regulate the osteogenic differentiation of BMSCs and senile osteoporosis. [PDF]

Cell Death Differ
The abnormal osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is an important cause of senile osteoporosis (SOP). Glutamine synthetase (GLUL) is a key enzyme in glutamine biosynthesis; however, its functional role in SOP remains ...
Zhang L, Qi B, Li Y, Liang X, Zhang Z, Yang T, Jia S, Gao X, Chen S, Jiao G, Li Y, Zhou H, Chen Y, Li Y, Zhang B, Li G, Meng C.   +16 more
europepmc   +5 more sources

TLR3 and GLUL orchestrate inflammatory and homeostatic imbalance in osteoarthritis [PDF]

Frontiers in Immunology
IntroductionOsteoarthritis (OA) is a degenerative joint disease marked by chronic inflammation, extracellular matrix degradation, and dysregulated cell death.
Jing Wang, Shenghao Xu, Bo Chen, Peiqiang Peng, Kai Wang, Yanguo Qin, Yanguo Qin   +6 more
doaj   +3 more sources

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression [PDF]

Advanced Science, EarlyView.
Glioblastoma (GBM) is a malignant brain tumor characterized by profound angiogenic activity and immunosuppressive features. A burgeoning body of research has focused on elucidating the functional effects of stromal cells within the tumor microenvironment
Qing Zhang, Yujie Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
semanticscholar   +3 more sources