Results 1 to 10 of about 3,985 (137)

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression [PDF]

Advanced Science
Glioblastoma (GBM) is a malignant brain tumor characterized by profound angiogenic activity and immunosuppressive features. A burgeoning body of research has focused on elucidating the functional effects of stromal cells within the tumor microenvironment
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
doaj   +3 more sources

Expanding the clinical and genetic spectrum of GLUL-related developmental and epileptic encephalopathy [PDF]

Scientific Reports
The GLUL gene encodes glutamine synthetase (GS), which plays a crucial role in glutamine–glutamate homeostasis. Both loss-of-function and gain-of-function variants of GLUL are known to cause genetic disorders in humans.
Dong Eon Oh, Se Song Jang, Woo Joong Kim, Soo Yeon Kim, Byung Chan Lim, Ki Joong Kim, Seungbok Lee, Jong-Hee Chae   +7 more
doaj   +4 more sources

Male proband with intractable seizures and a de novo start-codon-disrupting variant in GLUL [PDF]

HGG Advances
Summary: Bi-allelic variants in GLUL, encoding glutamine synthetase and responsible for the conversion of glutamate to glutamine, are associated with a severe recessive disease due to glutamine deficiency.
Elizabeth Carbonell, Sarah L. Stenton, Vijay S. Ganesh, Jialan Ma, Grace E. VanNoy, Lynn Pais, John N. Gaitanis, Melanie C. O’Leary, Heidi L. Rehm, Anne O’Donnell-Luria   +9 more
doaj   +4 more sources

TLR3 and GLUL orchestrate inflammatory and homeostatic imbalance in osteoarthritis [PDF]

Frontiers in Immunology
IntroductionOsteoarthritis (OA) is a degenerative joint disease marked by chronic inflammation, extracellular matrix degradation, and dysregulated cell death.
Jing Wang, Shenghao Xu, Bo Chen, Peiqiang Peng, Kai Wang, Yanguo Qin, Yanguo Qin   +6 more
doaj   +2 more sources

RHOJ derived peptide promotes chemosensitivity by inhibiting glutamine metabolism in gastric cancer [PDF]

Journal of Translational Medicine
Background Chemoresistance is a cause of chemotherapy failure in gastric cancer (GC) treatment. Recent studies have shown that the dysregulation of glutamine metabolism plays a pivotal role in promoting chemoresistance.
Jian Li, Huanqing Li, Fangzhou Ye, Jiayi Wang, Fan Li, Songhua Bei, Xiaohong Zhang, Jun Jiang, Li Feng   +8 more
doaj   +2 more sources

Bioinformatics-based study on the regulatory network of lipid metabolism-related genes and mechanisms in coronary heart disease [PDF]

Hereditas
Coronary heart disease (CHD), is a complex cardiovascular disease driven by atherosclerosis, resulting from a dynamic interplay between dysregulated lipid metabolism and chronic inflammation.
Zunxiong Xiao, Liping Wang, Haoqing Shao, Xiaoying Tian, Qinfang Zheng, Xudong Li   +5 more
doaj   +2 more sources

Specific inhibition of glutamine synthase involved in the metabolic pathway of amino acids is associated with anti-arthritic effects of sinomenine hydrochloride [PDF]

Frontiers in Cell and Developmental Biology
Sinomenine (SIN) is the key bioactive alkaloid isolated from Sinomenium acutum which has been prescribed commonly in Chinese medicine for managing rheumatic disorders.
Gejing Li, Gejing Li, Zhaoli Su, Yuanyuan Tang, Hong Huang, Junlan Zhang, Ye Lin, Qin Zhang, Xiong Cai, Xiong Cai   +9 more
doaj   +2 more sources

ALDH1L1 reverses CD8+ T cell exhaustion in the oral squamous cell carcinoma microenvironment by reprogramming L-glutamate metabolism [PDF]

Journal of Translational Medicine
Background Oral squamous cell carcinoma (OSCC) induces CD8⁺ T-cell exhaustion within the tumor microenvironment (TME) through metabolic reprogramming, contributing to the limited efficacy of immunotherapy. Targeting tumor metabolism is a pivotal strategy.
Guanzheng Chen, Shuqi Zhao, Lin Zhu, Shifeng Wu, Jia Kang, Minghui Mao, Zhengxue Han, Yi Qu   +7 more
doaj   +2 more sources

Ion channels and atrial fibrillation: mitophagy as a key mediator [PDF]

Frontiers in Physiology
BackgroundThe prevalence of atrial fibrillation (AF) is increasing due to the aging population. Mitophagy is crucial for maintaining cardiomyocyte function, while ion channels play a key role in cardiac electrical activity.
Xize Wu, Xiaorui Yan, Ruoxi Ma, Qiuying Wu, Xue Pan, Qihua Wu, Jiaqi Ren, Yuxi Huang, Shan Gao, Yue Li, Lihong Gong   +10 more
doaj   +2 more sources

Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction [PDF]

Frontiers in Immunology
BackgroundPreeclampsia, a hypertensive disorder during pregnancy affecting 2-8% of pregnancies globally, remains a leading cause of maternal and fetal morbidity.
Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng   +6 more
doaj   +2 more sources