Results 91 to 100 of about 6,846 (179)

Ibudilast Protects Retinal Bipolar Cells From Excitotoxic Retinal Damage and Activates the mTOR Pathway

Glia, Volume 73, Issue 5, Page 905-927, May 2025.
Main Points Ibudilast, a MIF and PDE inhibitor, preserves the form and function of the retina, especially bipolar cells, during excitotoxic damage. Ibudilast upregulates multiple signaling pathways, including mTOR, in damaged Müller glia and bipolar cells.
Sumaya Hamadmad, Tyler Heisler‐Taylor, Sandeep Goswami, Evan Hawthorn, Sameer Chaurasia, Dena Martini, Diana Summitt, Ali Zatari, Rahaf Shalash, Misha Sohail, Elizabeth G. Urbanski, Kayla Bernstein, Julie Racine, Abhay Satoskar, Heithem M. El‐Hodiri, Andy J. Fischer, Colleen M. Cebulla   +16 more
wiley   +1 more source

The metabolic reprogramming of γ-aminobutyrate in oral squamous cell carcinoma. [PDF]

BMC Oral Health
Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. The oncometabolites have been studied in OSCC, but the mechanism of metabolic reprogramming remains unclear.
Wu SL, Zha GY, Tian KB, Xu J, Cao MG.
europepmc   +2 more sources

snRNA‐Seq and Spatial Transcriptome Reveal Cell–Cell Crosstalk Mediated Metabolic Regulation in Porcine Skeletal Muscle

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 2, April 2025.
ABSTRACT Background Cell–cell crosstalk between myogenic, adipogenic and immune cells in skeletal muscle to regulate energy metabolism and lipid deposition has received considerable attention. The specific mechanisms of interaction between the different cells in skeletal muscle are still unclear.
Liu Guo, Mengmeng Han, Junfei Xu, Wenyue Zhou, Hanjing Shi, Sisi Chen, Weijun Pang, Xing Zhang, Yehui Duan, Yulong Yin, Fengna Li   +10 more
wiley   +1 more source

DNA hypermethylation preceded by H3K27 trimethylation is linked to downregulation of gene expression in disuse muscle atrophy in male mice

Physiological Reports, Volume 13, Issue 7, April 2025.
Abstract Disuse muscle atrophy can result in downregulated gene expression vital to muscle integrity, yet the mechanisms driving this downregulation remain unclear. Epigenetic alterations regulate transcriptional potential, with repressive changes suppressing gene expression.
Junya Shimizu, Fuminori Kawano
wiley   +1 more source

Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease

Neurobiology of Disease, 2006
Mild cognitive impairment (MCI) is generally referred to the transitional zone between normal cognitive function and early dementia or clinically probable Alzheimer's disease (AD).
D. Allan Butterfield, H. Fai Poon, Daret St. Clair, Jeffery N. Keller, William M. Pierce, Jon B. Klein, William R. Markesbery   +6 more
doaj  

Transcriptomic Dysregulation in Animal Models of Attention‐Deficit Hyperactivity Disorder and Nicotine Dependence Suggests Shared Neural Mechanisms

Brain and Behavior, Volume 15, Issue 3, March 2025.
Around 50% of people with attention‐deficit hyperactivity disorder (ADHD) develop nicotine dependence (ND); however, the mechanism for this relationship is unknown, and current treatments for ADHD do not prevent or slow the onset of ND. Transcriptomic analysis of the striatum and whole brains of three rodent models of ADHD and two of ND supports a role
Sarah Van Horn, Heather Driscoll, Donna J Toufexis   +2 more
wiley   +1 more source

Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract. [PDF]

J Pharm Anal
Natural products (NPs) have historically been a fundamental source for drug discovery. Yet the complex nature of NPs presents substantial challenges in pinpointing bioactive constituents, and corresponding targets.
Xu R, Yu H, Wang Y, Li B, Chen Y, Liu X, Xu T.   +6 more
europepmc   +2 more sources

Label-free proteomic analysis reveals the hepatoprotective mechanism of gypenosides in liver injury rats. [PDF]

Front Pharmacol
Chronic liver disease, a long-term condition resulting from various causes such as alcohol abuse, metabolic disorders, and viral hepatitis, is becoming a significant global health challenge.
Chen Y, Ma L, Wang Y, Zhang J, Pei T, Wang M.   +5 more
europepmc   +2 more sources

Are we there yet? Exploring astrocyte heterogeneity one cell at a time

Glia, Volume 73, Issue 3, Page 619-631, March 2025.
Main Points Astrocytes are present throughout the entire central nervous system where they play critical support functions and respond to injury and disease. In both health and disease, astrocytes show strikingheterogeneity. 'In this review we discuss how astrocyte heterogeneity is assessed by single cell and spatial transcriptomic approaches, what we ...
Michael R. O'Dea, Philip Hasel
wiley   +1 more source

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease. [PDF]

, 2016
Huntington's disease (HD) is a fatal neurodegenerative disease in which an early and selective vulnerability of striatal Spiny Projection Neurons is observed.
Déglon, N., Jollé, C., Merienne, N., Meunier, C., Pellerin, L.   +4 more
core   +2 more sources