Results 111 to 120 of about 7,531 (182)

RIP Kinase-Mediated Necrosis as an Alternative Mechanism of Photoreceptor Death [PDF]

, 2013
Photoreceptor cell death is the terminal event in a variety of retinal disorders including age-related macular degeneration, retinitis pigmentosa, and retinal detachment.
Miller, Joan Whitten, Murakami, Yusuke, Vavvas, Demetrios   +2 more
core  

Minireview on Glutamine Synthetase Deficiency, an Ultra-Rare Inborn Error of Amino Acid Biosynthesis

Biology, 2016
Glutamine synthetase (GS) is a cytosolic enzyme that produces glutamine, the most abundant free amino acid in the human body. Glutamine is a major substrate for various metabolic pathways, and is thus an important factor for the functioning of many ...
Marta Spodenkiewicz, Carmen Diez-Fernandez, Véronique Rüfenacht, Corinne Gemperle-Britschgi, Johannes Häberle   +4 more
doaj   +1 more source

Asean-China Free Trade Agreement: Tantangan Dan Peluang Bagi Indonesia [PDF]

, 2010
The Free trade agreement between ASEAN and China will have a significant impact on the Indonesian economy. Many observers predicted that Indonesia will be flooded by cheap import products from China after the implementation of ACFTA.
Adam, L. (Latif), Negara, S. D. (Siwage)
core  

cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish

Journal of Cardiovascular Development and Disease
Carnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation during zebrafish
Xiaohan Cheng, Jingyi Ju, Wenping Huang, Zongyi Duan, Yanchao Han   +4 more
doaj   +1 more source

Characterization of Quantum Chaos by the Autocorrelation Function of Spectral Determinants

, 1996
The autocorrelation function of spectral determinants is proposed as a convenient tool for the characterization of spectral statistics in general, and for the study of the intimate link between quantum chaos and random matrix theory, in particular.
Altland A, Berry M V, Bogomolny E B, Cheung J Y, D Klakow, Doron E, Dyson F J, Efetov K B, Haake F, Hannay H J, Keating J, Metropolis N, Muzykantskii B A, Plemelj J, S Kettemann, Smilansky U, Stratonovich R L, U Smilansky   +17 more
core   +1 more source

Neuroprotective effects of L-Dopa-modified zinc oxide nanoparticles on the rat model of 6-OHDA-ınduced Parkinson’s disease

Scientific Reports
Parkinson’s disease (PD) is a chronic neurodegenerative case. As the disease progresses, the response time to doses of levodopa (L-Dopa) becomes shorter and the effects of the drug are severely limited by some undesirable side effects such as the ‘on–off’
Yesim Yeni, Sıdıka Genc, Muhammed Sait Ertugrul, Hayrunnisa Nadaroglu, Arzu Gezer, Ali Sefa Mendil, Ahmet Hacımuftuoglu   +6 more
doaj   +1 more source

The cardioprotective mechanisms of draconis sanguis: An integrated network pharmacology, bioinformatics, and experimental validation study

Journal of Traditional Chinese Medical Sciences
Objective: To investigate the potential targets and mechanisms of Draconis Sanguis (DS), a valuable traditional Chinese medicine derived from the resin of the palm tree Daemonorops draco Bl (D. Sanguis, Xue Jie), in the treatment of myocardial infarction
Keyan Wang, Rongxin Zhu, Junjun Li, Binhua Yuan, Xiang Li, Yunlin Li, Mingyue Huang, Fangfang Rui, Chun Li, Wei Wang   +9 more
doaj   +1 more source

Label-free proteomic analysis reveals the hepatoprotective mechanism of gypenosides in liver injury rats

Frontiers in Pharmacology
Chronic liver disease, a long-term condition resulting from various causes such as alcohol abuse, metabolic disorders, and viral hepatitis, is becoming a significant global health challenge.
Yu Chen, Lizhou Ma, Yibo Wang, Jiarui Zhang, Tianhe Pei, Miao Wang   +5 more
doaj   +1 more source

Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract

Journal of Pharmaceutical Analysis
Natural products (NPs) have historically been a fundamental source for drug discovery. Yet the complex nature of NPs presents substantial challenges in pinpointing bioactive constituents, and corresponding targets.
Rui Xu, Hengyuan Yu, Yichen Wang, Boyu Li, Yong Chen, Xuesong Liu, Tengfei Xu   +6 more
doaj   +1 more source

Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization

Journal of Nanobiotechnology
Choroidal neovascularization (CNV) is a leading cause of visual impairment in wet age-related macular degeneration (wAMD). Recent investigations have validated the potential of reducing glutamine synthetase (GS) to inhibit neovascularization formation ...
Miaomiao Zhang, Xinyue Lu, Lifu Luo, Jinqiu Dou, Jingbo Zhang, Ge Li, Li Zhao, Fengying Sun   +7 more
doaj   +1 more source