Results 111 to 120 of about 6,846 (179)
Scientific ReportsParkinson’s disease (PD) is a chronic neurodegenerative case. As the disease progresses, the response time to doses of levodopa (L-Dopa) becomes shorter and the effects of the drug are severely limited by some undesirable side effects such as the ‘on–off’
Yesim Yeni +6 more
doaj +1 more source
Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis
Journal of Translational Medicine, 2018 Background Necroptotic susceptibility is probably an intrinsic weakness of cancer. Here, we report that resibufogenin, a member of bufadienolide family, suppresses the growth and metastasis of colorectal cancer (CRC) through induction of necroptosis in ...
Qinrui Han +7 more
doaj +1 more source
, 2013 Im Kikuyu, einer in Kenia gesprochenen Bantusprache, wird Fokus systematisch durch Wortstellung markiert. In dieser Arbeit werden die verschiedenen Varianten der Markierung von Fokus in Frage-Antwortsequenzen dargestellt. Nach einem Überblick über in der
Schwarz, Florian
core
Analysis of the glutamine dependent transaminases as possible therapeutic targets in colon cancer cells [PDF]
The project’s objective is to gain knowledge about the interconnection between cell growth and metabolism in the colon cancer cells HCT116 and RKO that rely on glutamine’s nitrogen.
Bayram, Șafak
core +1 more source
RIP Kinase-Mediated Necrosis as an Alternative Mechanism of Photoreceptor Death [PDF]
, 2013 Photoreceptor cell death is the terminal event in a variety of retinal disorders including age-related macular degeneration, retinitis pigmentosa, and retinal detachment.
Miller, Joan Whitten +2 more
core
Information on microwave beam power is given in viewgraph form. Information is given on orbit transfer proulsion applications, costs of delivering 100 kWe of usable power, and costs of delivering a 1 kg payload into ...
Faymon, Karl A.
core +1 more source
Molecular Marker-Facilitated Investigations of Quantitative Trait Loci in Maize. II. Factors Influencing Yield and Its Component Traits [PDF]
, 1987 Because traits such as grain yield are polygenically inherited and strongly influenced by environment, determination of genotypic values from phenotypic expression is not precise and improvement strategies are frequently based on low heritabilities ...
Edwards, M. D. +3 more
core +2 more sources
Journal of VirologyLiver-specific ten-eleven translocation (Tet) methylcytosine dioxygenases 2 and 3 (Tet2 plus Tet3)-deficient hepatitis B virus (HBV) transgenic mice fail to support viral biosynthesis.
Rachel Matrenec +7 more
semanticscholar +1 more source
Subtractive hybridization identifies stem cell-associated genes in an acute myeloid leukemia with poor prognosis [PDF]
, 2016 Introduction: Current prognostic markers have improved survival prediction, however, it has not advanced treatment strategies. Gene expression profiling may identify biological markers suitable as therapeutic targets.
Abdullah, Maha +4 more
core
Prion diseases disrupt the glutamate/glutamine metabolism in skeletal muscle
bioRxivIn prion diseases, aggregates of misfolded prion protein (PrPSc) accumulate not only in the brain but also in extraneural organs. This raises the question whether prion-specific pathologies arise also extraneurally.
Davide Caredio +10 more
semanticscholar +1 more source