PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma [PDF]
Science Advances, 2023 For clear cell renal cell carcinoma (ccRCC), lipid deposition plays important roles in the development, metastasis, and drug resistance. However, the molecular mechanisms underlying lipid deposition in ccRCC remain largely unknown.
Song Peng +18 more
semanticscholar +4 more sources
Homozygous
Clinical Genetics, 2020 Glutamine synthetase (GS) is the enzyme responsible for the biosynthesis of glutamine, providing the only source of endogenous glutamine necessary for several critical metabolic and developmental pathways.
Maian Roifman +20 more
semanticscholar +5 more sources
Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics [PDF]
Frontiers in Molecular Biosciences, 2022 Cellular glutamine synthesis is thought to be an important resistance factor in protecting cells from nutrient deprivation and may also contribute to drug resistance.
Şafak Bayram +8 more
semanticscholar +6 more sources
Neoplasma, 2020 Glutamine addiction is a major feature of glioma cells and plays an important role in its growth and proliferation. GLUL (glutamate-ammonia ligase), which catalyzes glutamate and ammonia to synthesize glutamine, plays a crucial role in tumor growth and ...
R. ZHANG +5 more
semanticscholar +6 more sources
Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival [PDF]
Journal of Cancer Research and Clinical Oncology, 2021 Glutamine plays an important role in cell viability and growth of various tumors. For the fetal subtype of hepatoblastoma, growth inhibition through glutamine depletion was shown.
Andreas Schmidt +9 more
semanticscholar +6 more sources
Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes [PDF]
Diabetes, 2015 Single nucleotide polymorphism (SNP) rs10911021 at the glutamate-ammonia ligase (GLUL) locus has been associated with an increased risk of coronary heart disease in individuals with type 2 diabetes.
Sabrina Prudente +10 more
semanticscholar +4 more sources
Two Siblings With Valproate-Related Hyperammonemia and Novel Mutations in Glutamine Synthetase (GLUL) Treated With Carglumic Acid [PDF]
Child Neurology Open, 2020 This case report describes 2 siblings with myoclonic epilepsy who had novel mutations in the glutamine synthetase (GLUL) gene: c.316C>T, p.(Arg106*) and c.42G>C, p.(Lys14Asn). Valproic acid improved seizure control, but was associated with hyperammonemic
Jennifer M. Bennett +4 more
semanticscholar +4 more sources
PO-249 GLUL knockdown induces drug resistance in non-small cell lung cancer cells
ESMO Open, 2018 Introduction Chemotherapy has advanced well in the treatment of Non-Small Cell Lung Cancers (NSCLCs), but its effectiveness is limited by drug resistance.
Magesh Muthu, Anders Nordström
semanticscholar +3 more sources
Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study [PDF]
Diabetes, 2015 Genetic studies have identified a glutamate-ammonia ligase gene (GLUL) polymorphism associated with cardiovascular disease morbidity and mortality among people with type 2 diabetes (T2D).
The Look AHEAD Research Group
semanticscholar +4 more sources
GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism [PDF]
Cancers, 2019 Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that GLUL ablation conferred resistance to several anticancer drugs in specific cancer cell lines while ...
Magesh Muthu +5 more
semanticscholar +7 more sources