LncRNA OIP5-AS1 Knockdown Targets miR-183-5p/GLUL Axis and Inhibits Cell Proliferation, Migration and Metastasis in Nasopharyngeal Carcinoma [PDF]
Frontiers in Oncology, 2022 Nasopharyngeal carcinoma (NPC) is often associated with the infection of Epstein-Barr virus in nasopharynx and is mainly happened in South China and Southeast Asia. Recently, noncoding RNAs have been reported to regulate NPC carcinogenesis. LncRNA OIP5-AS1 participates in tumorigenesis and progression; however, the inherent mechanism of OIP5-AS1 ...
Shuo Li +13 more
doaj +6 more sources
Immunohistochemical localisation of Glutamate ammonia ligase (GLUL) in cerebrum in different clinical forms of canine rabies [PDF]
Journal of Veterinary and Animal Sciences, 2023 Rabies, one of the earliest known diseases reported in the history of mankind, is a fatal acute viral disease of the central nervous system. Despite numerous studies on etiology of rabies, its exact mechanism of neuropathogenesis remains unidentified.
P. Nikhithasree +6 more
doaj +4 more sources
PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma [PDF]
Science Advances, 2023 For clear cell renal cell carcinoma (ccRCC), lipid deposition plays important roles in the development, metastasis, and drug resistance. However, the molecular mechanisms underlying lipid deposition in ccRCC remain largely unknown. By conducting an unbiased CRISPR-Cas9 screening, we identified the epigenetic regulator plant homeodomain ...
Song Peng +18 more
core +7 more sources
EXCLI journal, 2023 The glutamine synthetase path is one of the most important metabolic pathways in luminal breast cancer cells, which plays a critical role in supplying glutamine as an intermediate in the biosynthesis of amino acids and nucleotides. On the other hand, glycolysis and its dominant substrate, glucose, are the most critical players in cancer metabolism ...
Arezu Karimpur Zahmatkesh +3 more
doaj +6 more sources
Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival [PDF]
Journal of Cancer Research and Clinical Oncology, 2021 Abstract Purpose Glutamine plays an important role in cell viability and growth of various tumors. For the fetal subtype of hepatoblastoma, growth inhibition through glutamine depletion was shown. We studied glutamine depletion in embryonal cell lines of hepatoblastoma carrying different mutations.
Angela Armento +10 more
semanticscholar +6 more sources
GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism [PDF]
Cancers, 2019 Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that GLUL ablation conferred resistance to several anticancer drugs in specific cancer cell lines while leaving other cell lines non-resistant to the same drugs.
Magesh Muthu +5 more
semanticscholar +7 more sources
Neoplasma, 2020 Glutamine addiction is a major feature of glioma cells and plays an important role in its growth and proliferation. GLUL (glutamate-ammonia ligase), which catalyzes glutamate and ammonia to synthesize glutamine, plays a crucial role in tumor growth and proliferation.
J C Zhu +6 more
semanticscholar +7 more sources
Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes [PDF]
Diabetes, 2015 Single nucleotide polymorphism (SNP) rs10911021 at the glutamate-ammonia ligase (GLUL) locus has been associated with an increased risk of coronary heart disease in individuals with type 2 diabetes. The effect of this SNP on mortality was investigated among 1,242 white subjects with type 2 diabetes from the Joslin Kidney Study (JKS) (n = 416) and the ...
Diego Bailetti +17 more
semanticscholar +5 more sources
Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study [PDF]
Diabetes, 2015 Genetic studies have identified a glutamate-ammonia ligase gene (GLUL) polymorphism associated with cardiovascular disease morbidity and mortality among people with type 2 diabetes (T2D). We sought to determine whether GLUL rs10911021 is associated prospectively with adjudicated cardiovascular composite end points among overweight/obese individuals ...
semanticscholar +4 more sources
Genome‐wide association analysis identifies a GLUL haplotype for familial hepatitis B virus‐related hepatocellular carcinoma [PDF]
Cancer, 2017 BACKGROUNDA family history of liver cancer increases the risk of developing hepatocellular carcinoma (HCC) by 2‐fold to 10‐fold among patients with chronic hepatitis B virus (HBV). Previous genome‐wide association studies have identified many possible susceptible loci associated with sporadic HBV‐related HCC.
You‐Yu Lin +6 more
semanticscholar +6 more sources