Diabetes, 2023 Thermogenic adipocytes have been extensively investigated due to their energy dissipating property and therapeutic potential for obesity and diabetes.
Xiaowen Pan +14 more
semanticscholar +4 more sources
GutBackground SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in intrahepatic cholangiocarcinoma (ICC) remains unclear.
Mi Zhang +13 more
semanticscholar +3 more sources
Journal of Proteome Research, 2019 Hypoxia as well as metabolism are central hallmarks of cancer, and hypoxia-inducible factors (HIFs) and metabolic effectors are crucial elements in oxygen-compromised tumor environments.
Stephan Bernhardt +8 more
semanticscholar +5 more sources
Genome‐wide association analysis identifies a GLUL haplotype for familial hepatitis B virus‐related hepatocellular carcinoma [PDF]
Cancer, 2017 BACKGROUNDA family history of liver cancer increases the risk of developing hepatocellular carcinoma (HCC) by 2‐fold to 10‐fold among patients with chronic hepatitis B virus (HBV). Previous genome‐wide association studies have identified many possible susceptible loci associated with sporadic HBV‐related HCC.
You‐Yu Lin +6 more
semanticscholar +5 more sources
Journal of Hazardous MaterialsHexavalent chromium [Cr(VI)] exposure increases the risk of cancer occurrence. This study found that the levels of an atypical methyltransferase, METTL16 were greatly upregulated in the cells, and mouse tissues with Cr(VI) exposure, and played a critical role in cell proliferation and tumor growth induced by Cr(VI).
Yun-Xia Xie +8 more
semanticscholar +4 more sources
Comment on The Look AHEAD Research Group. Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes 2016;65:297–302 [PDF]
Diabetes, 2016 The Look AHEAD (Action for Health in Diabetes) Research Group (1) found that the C allele for rs10911021 was closely related to the primary composite end point of cardiovascular death and that intensive lifestyle intervention did not affect this correlation.
Haiyu Tang, Chuanyu Gao
semanticscholar +4 more sources
Response to Comment on The Look AHEAD Research Group. Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes 2016;65:297–302 [PDF]
Diabetes, 2016 We thank Drs. Tang and Gao for their letter (1) in response to our article (2) describing the association of rs10911021 with cardiovascular disease (CVD) in overweight/obese participants with type 2 diabetes in the the Look AHEAD (Action for Health in Diabetes) trial.
Jeanne M. McCaffery, Gordon S. Huggins
semanticscholar +4 more sources
Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase [PDF]
The American Journal of Human GeneticsGlutamine synthetase (GS), encoded by GLUL, catalyzes the conversion of glutamate to glutamine. GS is pivotal for the generation of the neurotransmitters glutamate and gamma-aminobutyric acid and is the primary mechanism of ammonia detoxification in the brain.
A. Jones +27 more
semanticscholar +5 more sources
HIF1α and HIF2α exert distinct nutrient preferences in renal cells. [PDF]
PLoS ONE, 2014 BackgroundHypoxia Inducible Factors (HIF1α and HIF2α) are commonly stabilized and play key roles related to cell growth and metabolic programming in clear cell renal cell carcinoma.
Alexandra Arreola +4 more
doaj +8 more sources