Journal of Hazardous MaterialsHexavalent chromium [Cr(VI)] exposure increases the risk of cancer occurrence. This study found that the levels of an atypical methyltransferase, METTL16 were greatly upregulated in the cells, and mouse tissues with Cr(VI) exposure, and played a critical role in cell proliferation and tumor growth induced by Cr(VI).
Yun-Xia, Xie +8 more
semanticscholar +4 more sources
Comment on The Look AHEAD Research Group. Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes 2016;65:297–302 [PDF]
Diabetes, 2016 The Look AHEAD (Action for Health in Diabetes) Research Group (1) found that the C allele for rs10911021 was closely related to the primary composite end point of cardiovascular death and that intensive lifestyle intervention did not affect this correlation.
Haiyu Tang, Chuanyu Gao
semanticscholar +5 more sources
PO-249 GLUL knockdown induces drug resistance in non-small cell lung cancer cells [PDF]
ESMO Open, 2018 ABSTRACT Introduction Chemotherapy has advanced well in the treatment of Non-Small Cell Lung Cancers (NSCLCs), but its effectiveness is limited by drug resistance. Unfortunately, cancer drug resistance becoming inevitable involving alterations in epigenetic regulation, molecular signalling, and metabolic rewiring.
M. Muthu, A. Nordstrom
semanticscholar +4 more sources
Response to Comment on The Look AHEAD Research Group. Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes 2016;65:297–302 [PDF]
Diabetes, 2016 We thank Drs. Tang and Gao for their letter (1) in response to our article (2) describing the association of rs10911021 with cardiovascular disease (CVD) in overweight/obese participants with type 2 diabetes in the the Look AHEAD (Action for Health in Diabetes) trial.
Jeanne M. McCaffery, Gordon S. Huggins
semanticscholar +5 more sources
Nucleosides, Nucleotides & Nucleic Acids, 2022 The central function of telomerase is maintaining the telomere length. However, several extra-telomeric roles have been identified for this protein complex. In this study, we evaluated the effect of the silencing of the catalytic subunit of telomerase (TERT) on the expression of candidate microRNAs, cell activation markers and glial-related genes in a ...
Yeimy González-Giraldo +2 more
semanticscholar +4 more sources
HIF1α and HIF2α exert distinct nutrient preferences in renal cells. [PDF]
PLoS ONE, 2014 BackgroundHypoxia Inducible Factors (HIF1α and HIF2α) are commonly stabilized and play key roles related to cell growth and metabolic programming in clear cell renal cell carcinoma.
Alexandra Arreola +4 more
doaj +8 more sources
Genomics, 1996 Glutamine synthetase (GS) is a ubiquitous enzyme that catalyzes the ATP-dependent conversion of glutamate to glutamine using ammonia as the nitrogen source. Using human GS cDNA as a probe, a bacterial artificial chromosome (BAC) library consisting of two-fold coverage of the human genome was screened, and 18 clones were obtained.
Jun Kudoh +5 more
semanticscholar +5 more sources
Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. [PDF]
PLoS ONE, 2014 The detoxification of ammonia occurs mainly through conversion of ammonia to urea in the liver via the urea cycle and glutamine synthesis. Congenital portosystemic shunts (CPSS) in dogs cause hyperammonemia eventually leading to hepatic encephalopathy ...
Giora van Straten +10 more
doaj +8 more sources
<b>Glutamine production by Glul promotes thermogenic adipocyte differentiation through Prdm9-mediated H3K4me3 and transcriptional </b><b>reprogram</b><b>ming</b> [PDF]
, 2023 <p><b>Abstract</b><br>Thermogenic adipocytes have been extensively investigated due to their energy dissipating property and therapeutic potential for obesity and diabetes. Besides serving as fuel sources, accumulating evidence suggests that intermediate metabolites play critical roles in multiple biological processes.
Zhuo-Xian Meng +14 more
+4 more sources
Sequence of E. coli tRNAGlulby automated sequential degradation
Nucleic Acids Research, 1975 A minor tRNA-Glu1 constituent of a preparation of E. coli B tRNA-Glu (Oak Ridge) has a guanosine residue at position 66 rather than an adenosine as in the tRNA-Glu2 described by Ohashi et al. (3). Automated sequential degradation was used to sequence this region.
A.J. Weinberger, Mayo Uziel
openaire +5 more sources