Results 81 to 90 of about 6,846 (179)

Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis

Advanced Science, Volume 12, Issue 18, May 15, 2025.
An unprecedented high‐resolution spatial atlas of the E. multilocularis infection foci is obtained, revealing the dynamic functions of neutrophils, Spp1+ macrophages, and fibroblasts during disease progression. The transition of parasite control strategy from “active killing” to “negative segregation” by the host may provide instructive insights into ...
Zhihua Ou, Li Li, Peidi Ren, Ting‐Ting Zhou, Fan He, Jialing Chen, Huimin Cai, Xiumin Han, Yao‐Dong Wu, Jiandong Li, Xiu‐Rong Li, Qiming Tan, Wenhui Li, Qi Chen, Nian‐Zhang Zhang, Xiuju He, Wei‐Gang Chen, Yanping Zhao, Jiwen Sun, Qian Zhang, Yan‐Tao Wu, Yingan Liang, Jie You, Guohai Hu, Xue‐Qi Tian, Sha Liao, Bao‐Quan Fu, Ao Chen, Xue‐Peng Cai, Huanming Yang, Jian Wang, Xin Jin, Xun Xu, Wan‐Zhong Jia, Junhua Li, Hong‐Bin Yan   +35 more
wiley   +1 more source

Identification of Potential Blind-Side Hypermelanosis-Related lncRNA–miRNA–mRNA Regulatory Network in a Flatfish Species, Chinese Tongue Sole (Cynoglossus semilaevis)

Frontiers in Genetics, 2022
Blind-side hypermelanosis has emerged as a major concern in commercial rearing environments of the flatfish aquaculture industry. To date, the underlying molecular mechanisms are not well understood.
Yangzhen Li, Yangzhen Li, Yuanri Hu, Yuanri Hu, Peng Cheng, Peng Cheng, Songlin Chen, Songlin Chen, Songlin Chen   +8 more
doaj   +1 more source

New Isozyme Systems for Maize (Zea mays L.): Aconitate Hydratase, Adenylate Kinase, NADH Dehydrogenase, and Shikimate Dehydrogenase [PDF]

, 1988
Electrophoretic variation and inheritance of four novel enzyme systems were studied in maize (Zea mays L.). A minimum of 10 genetic loci collectively encodes isozymes of aconitate hydratase (ACO; EC 4.2.1.3.), adenylate kinase (ADK; EC 2.7.4.3), NADH ...
Beckett, J. B., Goodman, Major, Stuber, Charles, Wendel, Jonathan, Wendel, Jonathan   +4 more
core   +3 more sources

Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers [PDF]

, 2020
Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB activation.
Ashelford, Kevin, Corcoran, David B, Fegan, Christopher D, Giles, Peter J, Lewis, Thomas, Pepper, Andrea G S, Pepper, Christopher, Rahman, Khondaker Miraz, Thurston, David E, Walsby, Elisabeth J   +9 more
core   +4 more sources

hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

Advanced Science, Volume 12, Issue 20, May 29, 2025.
This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du   +13 more
wiley   +1 more source

Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment

Journal of Neuroinflammation, 2019
Background Extracellular vesicles (EVs) are nano-sized particles present in most body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in HIV+ individuals.
Debjani Guha, David R. Lorenz, Vikas Misra, Sukrutha Chettimada, Susan Morgello, Dana Gabuzda   +5 more
doaj   +1 more source

Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer [PDF]

, 2008
SummaryHepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/β-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating
Andrei Goga, Asha Balakrishnan, Assou, Aurélien De Reyniès, Benhamouche, Boyault, Braeuning, Cadoret, Capurro, Carolina Armengol, Cavard, Claire-Angélique Renard, David Rickman, de La Coste, Dekel, Dominique Berrebi, Dominique Pasquier, Dominique Zachar, Emilie Thomas, Florence Levillayer, Fodde, Francine Arbez-Gindre, François Plenat, Françoise Boman, Frédéric Gauthier, Giuseppe Basso, Glinsky, Goga, Hélène Jouan, Hélène Strick-Marchand, Ishak, Janick Selves, Jean-François Michiels, Kho, Kirmizis, Koch, Koch, Korinek, Laurence Brugières, Lee, Lionel Gresh, Lowry, Luc Marcellin, Ma, Madeleine Joubert, Malynn, Marco Pontoglio, Margaret Childs, Marie-Annick Buendia, Marie-Christine Rousselet-Chapeau, Marumoto, McLin, Merrill, Michael Grotzer, Michaela Semeraro, Micsenyi, Monique Fabre, Ober, Ortega, Otu, Paul Hofman, Paulette Bioulac-Sage, Perilongo, Raymonde Bouvier, Renard, Reya, Roskams, Schnater, Sekiya, Shachaf, Sophie Branchereau, Stahl, Stefano Cairo, Strick-Marchand, Subramanian, Taniguchi, Tomlinson, Vita, Véronique Laithier, Weber, Wei, Weinberg, Wohrle, Wu, Yamashita, Yamashita, Yang, Yann Nouet, Yu Wei, Yue, Zeller, Zender, Zimmermann   +92 more
core   +1 more source

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC

Advanced Science, Volume 12, Issue 20, May 29, 2025.
AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang   +15 more
wiley   +1 more source

Alternative cell death pathways and cell metabolism [PDF]

, 2013
While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells.
Fulda, Simone
core   +2 more sources

Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization. [PDF]

J Nanobiotechnology
Choroidal neovascularization (CNV) is a leading cause of visual impairment in wet age-related macular degeneration (wAMD). Recent investigations have validated the potential of reducing glutamine synthetase (GS) to inhibit neovascularization formation ...
Zhang M, Lu X, Luo L, Dou J, Zhang J, Li G, Zhao L, Sun F.   +7 more
europepmc   +2 more sources