Results 81 to 90 of about 7,531 (182)

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Identification of common mechanisms and biomarkers of atrial fibrillation and heart failure based on machine learning

ESC Heart Failure
Aims Atrial fibrillation (AF) is the most common arrhythmia. Heart failure (HF) is a disease caused by heart dysfunction. The prevalence of AF and HF were progressively increasing over time.
Zhijun Zhang, Jianying Ding, Xiaolong Mi, Yuanyuan Lin, Xinjian Li, Jun Lian, Jinwen Liu, Lijuan Qu, Bingye Zhao, Xuewen Li   +9 more
doaj   +1 more source

Acrolein Promotes Retinal Inflammation Through Macrophage Chemotaxis by Inducing CCL2 Production From Müller Cells

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Patients with proliferative diabetic retinopathy show elevated vitreous levels of the acrolein adduct FDP‐lys and CCL2. In rat Müller glial cells (TR‐MUL5), acrolein increases Ccl2 gene expression and CCL2 secretion and promotes macrophage migration.
Kanae Fukutsu, Miyuki Murata, Kasumi Kikuchi, Kousuke Noda, Susumu Ishida   +4 more
wiley   +1 more source

Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope. [PDF]

, 2011
BACKGROUND: A decline in the discovery of new antibacterial drugs, coupled with a persistent rise in the occurrence of drug-resistant bacteria, has highlighted antibiotics as a diminishing resource.
Bibb, Mervyn, Hesketh, Andy, Hill, Chris, Hong, Hee-Jeon, Mokhtar, Jehan, Novotna, Gabriela, Tran, Ngat   +6 more
core   +3 more sources

CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling

Journal of Nanobiotechnology, 2023
Despite rapid advances in metabolic therapies over the past decade, their efficacy in melanoma has been modest, largely due to the interaction between cancer-associated fibroblasts (CAFs) and cancer cells to promote cancer growth.
Chen Ai, Xiao Sun, Shan Xiao, Lu Guo, Mengmeng Shang, Dandan Shi, Dong Meng, Yading Zhao, Xiaoxuan Wang, Jie Li   +9 more
doaj   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

Global gene expression in endometrium of high and low fertility heifers during the mid-luteal phase of the estrous cycle [PDF]

, 2014
peer-reviewedBackground In both beef and dairy cattle, the majority of early embryo loss occurs within the first 14 days following insemination.
Diskin, Michael G., Kenny, David A., Killeen, Aideen P., Morris, Dermot G., Mullen, Michael P., Waters, Sinead M.   +5 more
core   +1 more source

A Pan‐Subtype Fatty Acid Metabolic Signature Reveals Universal Prognostic Stratification in Breast Cancer

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background Breast cancer exhibits profound molecular heterogeneity. Each subtype is characterized by distinct biological features, therapeutic responses, and prognostic outcomes. However, a unifying feature across most breast cancer subtypes is an adipocyte‐enriched microenvironment.
Yunjian Song, Jiayue Li, Meiyue Zhu, Yi Xia, Deqiang Wang, Zhenhua Sun, Liang Ou, Lei Yang   +7 more
wiley   +1 more source

Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia‐Reperfusion Injury

MedComm, Volume 7, Issue 1, January 2026.
We employed spatially resolved transcriptomics to visualize and molecularly characterize the spatial distribution of gene expression profiles in the rats’ left ventricles following MIR injury. Further experiments indicated that cardiogenic Piezo1‐mediated calcium overload exacerbates MIR through the activation of matrix metalloproteinase 2‐ryanodine ...
Zhen Li, Fan Jiang, Yan Chen, Zhixiao Li, Yanqiong Wu, Zhigang He, Duozhi Wu, Hongbing Xiang   +7 more
wiley   +1 more source

The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus [PDF]

, 2016
The high mortality risk of patients with type 2 diabetes mellitus may well be explained by the several comorbidities and/or complications. Also the intrinsic genetic component predisposing to diabetes might have a role in shaping the risk of diabetes ...
Alberico, Federica, Bacci, Simonetta, Cignarelli, Mauro, Copetti, Massimiliano, De Cosmo, Salvatore, Fontana, Andrea, Lamacchia, Olga, Marucci, Antonella, Mercuri, Luana, Pacilli, Antonio, Palena, Antonio, Prudente, Sabrina, Trischitta, Vincenzo, Viti, Raffaella   +13 more
core   +1 more source