Results 1 to 10 of about 17,873 (207)

Underlying mechanisms of phosphodiesterase 10A and glutamate-ammonia ligase genes that regulate inosine monophosphate deposition and thereby affect muscle tenderness in Jingyuan chickens [PDF]

Animal Bioscience, 2022
Objective Inosine monophosphate (IMP) is a key factor that imparts of meat flavor. Differences in the IMP content in the muscles were evaluated to improve chicken meat quality.
Weizhen Wang, Juan Zhang, Honghong Hu, Baojun Yu, Jintong He, Tingting Yao, Yaling Gu, Zhengyun Cai, Guosheng Xin   +8 more
doaj   +7 more sources

Immunohistochemical localisation of Glutamate ammonia ligase (GLUL) in cerebrum in different clinical forms of canine rabies [PDF]

Journal of Veterinary and Animal Sciences, 2023
Rabies, one of the earliest known diseases reported in the history of mankind, is a fatal acute viral disease of the central nervous system. Despite numerous studies on etiology of rabies, its exact mechanism of neuropathogenesis remains unidentified ...
P. Nikhithasree , C. Divya, M.L. Arya Nair, K. Krithiga, K.S. Prasanna , Lali F. Anand, John Bernet Johnson   +6 more
doaj   +3 more sources

Novel Glutamate–Putrescine Ligase Activity in Haloferax mediterranei: A New Function for glnA-2 Gene [PDF]

Biomolecules, 2021
The genome of the halophilic archaea Haloferax mediterranei contains three ORFs that show homology with glutamine synthetase (GS) (glnA-1, glnA-2, and glnA-3).
Verónica Rodríguez-Herrero, Arnau Peris, Mónica Camacho, Vanesa Bautista, Julia Esclapez, María-José Bonete   +5 more
doaj   +4 more sources

Binding of nickel to testicular glutamate-ammonia ligase inhibits its enzymatic activity. [PDF]

Mol Reprod Dev, 2011
Exposure to nickel has been shown to cause damage to the testis in several animal models. It is not known if the testis expresses protein(s) that can bind nickel. To test this, we used a nickel-binding assay to isolate testicular nickel-binding proteins.
Sun Y, Ou Y, Cheng M, Ruan Y, van der Hoorn FA.   +4 more
europepmc   +6 more sources

Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain [PDF]

Biomolecules, 2016
Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in excess of those of other amino acids. In glutamate-containing vesicles in the brain, the concentration of glutamate may even exceed 100 mM. Yet because glutamate is a
Arthur J. L. Cooper, Thomas M. Jeitner
doaj   +5 more sources

Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. [PDF]

PLoS ONE, 2014
The detoxification of ammonia occurs mainly through conversion of ammonia to urea in the liver via the urea cycle and glutamine synthesis. Congenital portosystemic shunts (CPSS) in dogs cause hyperammonemia eventually leading to hepatic encephalopathy ...
Giora van Straten, Frank G van Steenbeek, Guy C M Grinwis, Robert P Favier, Anne Kummeling, Ingrid H van Gils, Hille Fieten, Marian J A Groot Koerkamp, Frank C P Holstege, Jan Rothuizen, Bart Spee   +10 more
doaj   +9 more sources

Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes [PDF]

Cardiovascular Diabetology
Background A common genetic variant at the glutamate-ammonia ligase (GLUL) locus has been previously associated with an increased risk of coronary artery disease (CAD) as well as alterations of glutamic acid metabolism and the γ-glutamyl cycle in ...
Fernando M. A. Giuffrida, Sharan K. Rai, Yaling Tang, Christine Mendonça, Scott G. Frodsham, Hetal S. Shah, Marcus G. Pezzolesi, Qi Sun, Alessandro Doria   +8 more
doaj   +3 more sources

Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle. [PDF]

PLoS Pathog
In prion diseases (PrDs), aggregates of misfolded prion protein (PrP$^{Sc}$) accumulate not only in the brain but also in extraneural organs. This raises the question whether prion-specific pathologies arise also extraneurally.
Caredio D, Koderman M, Frontzek KJ, Sorce S, Nuvolone M, Bremer J, Mariutti G, Schwarz P, Madrigal L, Mitrovic M, Sellitto S, Streichenberger N, Scheckel C, Aguzzi A.   +13 more
europepmc   +4 more sources

High-Throughput Tn-Seq Screens Identify Both Known and Novel Pseudomonas putida KT2440 Genes Involved in Metal Tolerance. [PDF]

Environ Microbiol
Exposure of Pseudomonas putida KT2440 to toxic metals activates genes PP_1663, PP_5002, PP_5337, and the two‐component system RoxSR, possibly linked to membrane integrity, FeS cluster maintenance, and DNA transcription, offering new insights into bacterial adaptation to metal tolerance.
Royet K, Kergoat L, Lutz S, Oriol C, Parisot N, Schori C, Ahrens CH, Rodrigue A, Gueguen E.   +8 more
europepmc   +2 more sources

Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract [PDF]

Journal of Pharmaceutical Analysis
Natural products (NPs) have historically been a fundamental source for drug discovery. Yet the complex nature of NPs presents substantial challenges in pinpointing bioactive constituents, and corresponding targets.
Rui Xu, Hengyuan Yu, Yichen Wang, Boyu Li, Yong Chen, Xuesong Liu, Tengfei Xu   +6 more
doaj   +2 more sources