Results 51 to 60 of about 17,873 (207)

Regulation of Pseudomonas putida genes involved in the metabolism of acidic amino acids [PDF]

, 2003
Pseudomonas putida KT2440 has the ability to utilize a wide range of amino acids as carbon and nitrogen sources. Rapid growth of this organism is supported by the acidic amino acids (Asp and Glu) and their amides (Asn and Gln) when supplied as sole ...
Röhm, Klaus-Heinrich, Prof. Dr., Sonawane, Avinash M.   +1 more
core   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

70 MW-level picosecond mid-infrared radiation generation by difference frequency generation in AgGaS2, BaGa4Se7, LiGaSe2, and LiGaS2 [PDF]

IEEE Photonics Journal ( Volume: 17, Issue: 2, April 2025)
Comparative study of nonlinear crystals for picosecond difference frequency generation in mid-IR is presented. Nonlinear crystals of AgGaS$_2$, BaGa$_4$Se$_7$, LiGaSe$_2$, and LiGaS$_2$ were studied. Samples of AgGaS$_2$, BaGa$_4$Se$_7$, LiGaSe$_2$, and LiGaS$_2$ were tested in thee sets having lengths of 2, 4, or 8 mm.
arxiv   +1 more source

Reinforcement Learning-Driven Linker Design via Fast Attention-based Point Cloud Alignment [PDF]

arXiv, 2023
Proteolysis-Targeting Chimeras (PROTACs) represent a novel class of small molecules which are designed to act as a bridge between an E3 ligase and a disease-relevant protein, thereby promoting its subsequent degradation. PROTACs are composed of two protein binding "active" domains, linked by a "linker" domain.
arxiv  

Application of Conservation Genomics to Investigate the Role of Pathogens on the Migration of Sea‐Run Brown Trout (Salmo trutta)

Journal of Fish Diseases, Volume 48, Issue 5, May 2025.
ABSTRACT Pathogens play a key role in individual function and the dynamics of wild populations, but the link between pathogens and individual performance has rarely been investigated in the wild. Migrating salmonids offer an ideal study system to investigate how infection with pathogens affects performance given that climate change and fish farming ...
Robert J. Lennox, Sindre H. Eldøy, Angela D. Schulze, Kristina M. Miller, Trond Einar Isaksen, Jan G. Davidsen, Cecilie I. Nilsen, Lotte S. Dahlmo, Knut Wiik Vollset   +8 more
wiley   +1 more source

Mind the GAPS: Glia associated with psychological stress

Journal of Neuroendocrinology, EarlyView.
Abstract Glial cells are an integral component of the nervous system, performing crucial functions that extend beyond structural support, including modulation of the immune system, tissue repair, and maintaining tissue homeostasis. Recent studies have highlighted the importance of glial cells as key mediators of stress responses across different organs.
Niklas Blank, Molly Weiner, Shaan Patel, Sarah Köhler, Christoph A. Thaiss   +4 more
wiley   +1 more source

Poly(dA:dT)-rich DNAs are highly flexible in the context of DNA looping [PDF]

PLOS ONE 8(10): e75799, 2013
Large-scale DNA deformation is ubiquitous in transcriptional regulation in prokaryotes and eukaryotes alike. Though much is known about how transcription factors and constellations of binding sites dictate where and how gene regulation will occur, less is known about the role played by the intervening DNA. In this work we explore the effect of sequence
arxiv   +1 more source

Co-Cultures of Oophila Amblystomatis Between Ambystoma Maculatum and Ambystoma Gracile Hosts Show Host-Symbiont Fidelity [PDF]

, 2019
A unique symbiosis occurs between embryos of the spotted salamander (Ambystoma maculatum) and a green alga (Oophila amblystomatis). Unlike most vertebrate host-symbiont relationships, which are ectosymbiotic, A.
Burns, John, Hill, Elizabeth M., Kerney, Ryan R., Kim, Eunsoo, Leavitt, Jasper S., Zhang, Huanjia   +5 more
core   +1 more source

Rre37 stimulates accumulation of 2-oxoglutarate and glycogen under nitrogen starvation in Synechocystis sp. PCC 6803 [PDF]

, 2013
Rre37 (sll1330) in a cyanobacterium Synechocystis sp. PCC 6803 acts as a regulatory protein for sugar catabolic genes during nitrogen starvation. Low glycogen accumulation in Δrre37 was due to low expression of glycogen anabolic genes. In addition to low
Aikawa, Shimpei, Hasunuma, Tomohisa, Hirai, Masami Yokota, Joseph, Ancy, Kondo, Akihiko, Matsuda, Fumio, Osanai, Takashi, Sasaki, Kengo, Teramura, Hiroshi   +8 more
core   +1 more source

Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Anticancer chemotherapy is an underappreciated contributor to cancer cachexia, an often‐irreversible body‐wasting condition that causes 20%–30% of cancer‐related deaths. An obstacle to predicting, monitoring and understanding the mechanisms underlying chemotherapy cachexia is that each cancer (and subtype) is assigned different ...
Dean G. Campelj, Cara A. Timpani, Guinevere Spiesberger, Luke E. Formosa, Joel R. Steele, Haijian Zhang, Ralf B. Schittenhelm, Lewis Leow, Craig A. Goodman, Emma Rybalka   +9 more
wiley   +1 more source