Results 61 to 70 of about 17,873 (207)

Exploring the biological and chemical complexity of the ligases. [PDF]

, 2014
Using a novel method to map and cluster chemical reactions, we have re-examined the chemistry of the ligases [Enzyme Commission (EC) Class 6] and their associated protein families in detail.
Furnham, Nicholas, Holliday, Gemma L, Rahman, Syed Asad, Thornton, Janet M   +3 more
core   +1 more source

Neural Metabolic Networks: Key Elements of Healthy Brain Function

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer, Nirma D. Perera, Nonthué A. Uccelli, Alice Abbondanza, Jens V. Andersen, Emma Veronica Carsana, Matthew D. Demmings, Regina F. Fernandez, Matheus Garcia de Fragas, Ismail Gbadamosi, Divita Kulshrestha, Ricardo A. S. Lima‐Filho, Oana C. Marian, Kia H. Markussen, Andrew J. McGovern, Elliott S. Neal, Sukanya Sarkar, Eva Šimončičová, Jazmín Soto‐Verdugo, Sozerko Yandiev, Ignacio Fernández‐Moncada   +20 more
wiley   +1 more source

Alternative cell death pathways and cell metabolism [PDF]

, 2013
While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells.
Fulda, Simone
core   +2 more sources

Proteome Reprogramming and Acquired Stress Tolerance in Potato Cells Exposed to Acute or Stepwise Water Deficit

Plant, Cell &Environment, Volume 48, Issue 5, Page 2875-2894, May 2025.
ABSTRACT Water deficit negatively impacts crop productivity and quality. Plants face these challenges by adjusting biological processes and molecular functions according to the intensity and duration of the stress. The cultivated potato (Solanum tuberosum) is considered sensitive to water deficit, thus breeding efforts are needed to enhance its ...
Elisa Cappetta, Carmine Del Regno, Sara Ceccacci, Maria Chiara Monti, Lucio Spinelli, Marisa Conte, Chiara D'Anna, Mariaevelina Alfieri, Mariapia Vietri, Antonello Costa, Antonietta Leone, Alfredo Ambrosone   +11 more
wiley   +1 more source

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

Cell Reports, 2019
Summary: Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of
Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong   +28 more
doaj  

Pathogen and Gene Expression Profiles of Atlantic Salmon From an Endangered Population

Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 35, Issue 4, April 2025.
ABSTRACT The role of pathogens in impacting the behaviour and fate of salmonids has been studied extensively for some selected pathogens such as sea lice. However, the whole pathobiome of the fish are seldom considered and may confound and influence the study species in situ.
Robert J. Lennox, Angela D. Schulze, Kristi M. Miller, Trond Einar Isaksen, Eirik Straume Normann, Cecilie Iden Nilsen, Lotte S. Dahlmo, Bjørn T. Barlaup, Elisabeth Stöger, Sindre H. Eldøy, Knut Wiik Vollset   +10 more
wiley   +1 more source

Prion diseases disrupt the glutamate/glutamine metabolism in skeletal muscle

bioRxiv
In prion diseases, aggregates of misfolded prion protein (PrPSc) accumulate not only in the brain but also in extraneural organs. This raises the question whether prion-specific pathologies arise also extraneurally.
Davide Caredio, Maruša Koderman, K. Frontzek, S. Sorce, M. Nuvolone, J. Bremer, Petra Schwarz, Stefano Sellitto, Nathalie Streichenberger, C. Scheckel, Adriano Aguzzi   +10 more
semanticscholar   +1 more source

Plasticity of Root System Architecture and Whole Transcriptome Responses Underlying Nitrogen Deficiency Tolerance Conferred by a Wild Emmer Wheat QTL

Plant, Cell &Environment, Volume 48, Issue 4, Page 2835-2855, April 2025.
ABSTRACT Our aim was to elucidate mechanisms underlying nitrogen (N)‐deficiency tolerance in bread wheat (cultivar Ruta), conferred by a wild emmer wheat QTL (WEW; IL99). We hypothesised that the tolerance in IL99 is driven by enhanced N‐uptake through modification of root system architecture (RSA) underscored by transcriptome modifications.
Nikolai Govta, Liubov Govta, Hanan Sela, Gadi Peleg, Assaf Distelfeld, Tzion Fahima, Diane M. Beckles, Tamar Krugman   +7 more
wiley   +1 more source

Postnatal development of rat retina: a continuous observation and comparison between the organotypic retinal explant model and in vivo development

Neural Regeneration Research
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.
Baoqi Hu, Rui Wang, Hanyue Zhang, Xiou Wang, Sijia Zhou, Bo Ma, Yan Luan, Xin Wang, Xinlin Chen, Zhichao Zhang, Qianyan Kang   +10 more
doaj   +1 more source

Replication of proto-RNAs sustained by ligase-helicase cycle in oligomer world [PDF]

arXiv, 2013
A mechanism of the replication of proto-RNAs in oligomer world is proposed. The replication is carried out by a minimum cycle which is sustained by a ligase and a helicase. We expect that such a cycle actually worked in the primordial soup and can be constructed in vitro.
arxiv