Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. [PDF]
J Biol Chem, 2012 GSH is synthesized sequentially by glutamate-cysteine ligase (GCL) and GSH synthase and defends against oxidative stress, which promotes hepatic stellate cell (HSC) activation. Changes in GSH synthesis during HSC activation are poorly characterized.
Ramani K +4 more
europepmc +4 more sources
Post-translational Activation of Glutamate Cysteine Ligase with Dimercaprol: A NOVEL MECHANISM OF INHIBITING NEUROINFLAMMATION IN VITRO. [PDF]
J Biol Chem, 2017 McElroy PB, Sri Hari A, Day BJ, Patel M.
europepmc +3 more sources
Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage. [PDF]
Front Physiol, 2016 Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy
Lavoie S +5 more
europepmc +4 more sources
Journal of Food Quality, 2022 This study aims to evaluate the protective effects of feruloyl oligosaccharides from fermented wheat bran (FOs-FWB) against oxidative stress in IPEC-J2 cells in vitro and in a zebrafish model in vivo.
Jia Zhang +8 more
doaj +1 more source
Nature Communications, 2022 Follicular and marginal zone B (FoB and MZB, respectively) cells have divergent metabolic characteristics. Here the authors show that deficiency of glutamate cysteine ligase (Gclc), the enzyme for glutathione synthesis, differentially impacts FoB and MZB
Davide G. Franchina +21 more
doaj +1 more source
Nrf2 Regulation by Curcumin: Molecular Aspects for Therapeutic Prospects
Molecules, 2021 Nuclear factor erythroid 2 p45-related factor (2Nrf2) is an essential leucine zipper protein (bZIP) that is primarily located in the cytoplasm under physiological conditions.
Seyed Hossein Shahcheraghi +6 more
doaj +1 more source
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo
Molecules, 2021 This study evaluated the neuroprotective effects and mechanisms of procyanidins (PCs). In vitro, rat pheochromocytoma cells (PC12 cells) were exposed to PCs (1, 2 or 4 μg/mL) or N-Acetyl-L-cysteine (NAC) (20 μM) for 24 h, and then incubated with 200 μM ...
Juan Chen +6 more
doaj +1 more source
Molecules, 2022 Inflammation accompanies hepatic dysfunction resulting from tissue oxidative damage. Naringenin (Nar), a natural flavanone, has known antioxidant and anti-inflammatory activities, but its mechanism of action in the regulation of liver dysfunction ...
Mengting Ji +11 more
doaj +1 more source
Characterization of a glutamate-cysteine ligase in Bombyx mori
Molecular Biology Reports, 2022 Abstract Background: Glutamate cysteine ligase (GCL) is a crucial enzyme involved in the synthesis of glutathione (GSH). Despite various studies on glutathione transferase and its essential role in detoxification and resistance to oxidative stress, GSH synthesis has not been described in silkworms to date.
Wazifa Afrin +2 more
openaire +2 more sources
Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. [PDF]
, 2020 Oxidative stress and chronic inflammation play critical roles in the pathogenesis of ulcerative colitis (UC) and inflammatory bowel diseases (IBD). A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium ...
Farzaneh, Ted +8 more
core +2 more sources