Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis. [PDF]
Chembiochem, 2023 Abstract Dysregulated oxidative stress plays a major role in cancer pathogenesis and some types of cancer cells are particularly vulnerable to inhibition of their cellular antioxidant capacity. Glutamate‐cysteine ligase (GCL) is the first and rate‐limiting step in the synthesis of the major cellular antioxidant glutathione (GSH ...
Zhang LH +9 more
europepmc +5 more sources
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. [PDF]
Cell Metab, 2021 Cysteine is required for maintaining cellular redox homeostasis in both normal and transformed cells. Deprivation of cysteine induces the iron-dependent form of cell death known as ferroptosis; however, the metabolic consequences of cysteine starvation beyond impairment of glutathione synthesis are poorly characterized.
Kang YP +7 more
europepmc +4 more sources
Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase. [PDF]
Acta Neuropathol Commun, 2015 Tuberous sclerosis complex (TSC) is a genetic disease resulting from mutation in TSC1 or TSC2 and subsequent hyperactivation of mammalian Target of Rapamycin (mTOR). Common TSC features include brain lesions, such as cortical tubers and subependymal giant cell astrocytomas (SEGAs).
Malik AR +18 more
europepmc +7 more sources
Post-translational Activation of Glutamate Cysteine Ligase with Dimercaprol: A NOVEL MECHANISM OF INHIBITING NEUROINFLAMMATION IN VITRO. [PDF]
J Biol Chem, 2017 McElroy PB, Sri Hari A, Day BJ, Patel M.
europepmc +3 more sources
Altered glutamate cysteine ligase expression and activity in renal cell carcinoma. [PDF]
Biomed Rep, 2014 Oxidative stress has been linked to the progression of mutations and cancer. Increased glutathione (GSH) contents have been observed in a number of different human cancer tissues. GSH is synthesized de novo in a two-step process catalyzed by glutamate cysteine ligase (GCL).
Li M, Zhang Z, Yuan J, Zhang Y, Jin X.
europepmc +4 more sources
Characterization of a glutamate-cysteine ligase in Bombyx mori
Molecular Biology Reports, 2022 Abstract Background: Glutamate cysteine ligase (GCL) is a crucial enzyme involved in the synthesis of glutathione (GSH). Despite various studies on glutathione transferase and its essential role in detoxification and resistance to oxidative stress, GSH synthesis has not been described in silkworms to date.
Wazifa Afrin +2 more
openaire +2 more sources
Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis. [PDF]
PLoS ONE, 2009 BACKGROUND: During acute pancreatitis (AP), oxidative stress contributes to intestinal barrier failure. We studied actions of multispecies probiotics on barrier dysfunction and oxidative stress in experimental AP.
Femke Lutgendorff +10 more
doaj +1 more source
Caffeic acid and protocatechuic acid modulate Nrf2 and inhibit Ehrlich ascites carcinomas in mice
Asian Pacific Journal of Tropical Biomedicine, 2021 Objective: To assess the nuclear factor-erythroid 2-related factor-2 (Nrf2) modulatory effect of caffeic acid and protocatechuic acid and determine the anti-tumor activity of these phenolic compounds against Ehrlich ascites carcinoma growth in mice ...
Venugopal R Bovilla +7 more
doaj +1 more source
Glutamate-cysteine ligase catalytic subunit is associated with cisplatin resistance in lung adenocarcinoma. [PDF]
Jpn J Clin Oncol, 2018 Cisplatin is a key drug for treating lung adenocarcinoma, and its sensitivity to cisplatin is directly related to prognosis. We aimed to reveal the roles of genes related to glutathione synthesis (glutamate-cysteine ligase catalytic subunit, GCLC) and cystine uptake (cystine/glutamate transporter, xCT and CD44v8-10) in cisplatin resistance and ...
Hiyama N +10 more
europepmc +4 more sources
Liver Research, 2020 Background and aim: Acetaminophen (APAP) overdose is a major cause of acute liver injury, but the role of macrophages in the propagation of the hepatotoxicity is controversial.
Melissa M. Clemens +5 more
doaj +1 more source