Results 151 to 160 of about 41,693 (219)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Coordinated transcriptional regulation between a reactive oxygen species-responsive gene network and the circadian clock in Arabidopsis thaliana : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Plant Biology at Massey University, Plant Biology, New Zealand [PDF]

, 2012
Most organisms have evolved endogenous biological clocks as internal timekeepers to fine-tune physiological processes to the external environment. Energetic cycles such as photosynthesis and glycolytic cycles are physiological processes that have ...
Lai, Alvina Grace
core  

Molecular Mechanisms and Therapeutic Potential of DJ‐1 in Skeletal Muscle Homeostasis and Disease

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
DJ‐1 protein functions as a redox‐sensing guardian in skeletal muscle by coordinating antioxidant defense, mitochondrial homeostasis, metabolic adaptation, and anti‐atrophy signaling. Enhancing its function holds promise as a potential therapeutic strategy for muscle atrophy, ALS, and metabolic myopathies.
Yue Zhang, Menghuan Li, Xiaojing Xie, Baokai Tian, Zhenwei Bao, Xuejie Yi   +5 more
wiley   +1 more source

Dose‐Dependent Biphasic Effect of Palmitic Acid on Oligodendrocyte Function: Impacts on Viability, Differentiation, and Myelination

Journal of Cellular Physiology, Volume 241, Issue 2, February 2026.
Schematic diagram showing dose‐dependent effects of PA in oligodendrocyte precursor MO3.13 cells and rodent organotypic hippocampal and cerebellar slice cultures. High doses lead to cell death accompanied by mitochondrial impairment, whereas low doses activate the Nrf2 antioxidant response and exert neuroprotective effect while balancing mitochondrial ...
Anna Palmiero, Luca Pipicelli, Giuliana La Rosa, Concetta Sozio, Carolina Punziano, Maddalena Raia, Raffaella Faraonio, Giovanna Vitolo, Mariarosaria Cammarota, Francesca Boscia, Ciro Menale, Mariarosaria Santillo, Simona Damiano   +12 more
wiley   +1 more source

Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway.

PLoS ONE, 2019
Large-scale breeding environments often lead to oxidative stress. Macrophages play an important role in the immune system and are vulnerable to reactive oxygen species (ROS), which result in macrophage death.
Xinyu Lin, Dingping Bai, Zixi Wei, Ying Zhang, Yifan Huang, Hui Deng, Xiaohong Huang   +6 more
doaj   +1 more source

N‐Acetylcysteine‐Loaded Scaffolds and Their Role in Extracellular ROS and Redox‐Related Gene Regulation in Chondrocytes

Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.
This study develops N‐acetylcysteine‐loaded polycaprolactone fibers for cartilage regeneration to investigate their potential in regulating redox balance. The fibers exhibit antioxidant properties and modulate genes related to glutathione and transsulfuration pathways.
Kubra Yigit, Anthony Callanan
wiley   +1 more source

Differences in Src phosphorylation of PSD‐93 and PSD‐95 drive differences in scaffolding activity

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Frank A. Mindlin, Moeka Sasazawa, James Byrnes, Mark E. Bowen   +3 more
wiley   +1 more source

Molybdenum and cadmium co-induce apoptosis and ferroptosis through inhibiting Nrf2 signaling pathway in duck (Anas platyrhyncha) testes

Poultry Science
: Cadmium (Cd) and high molybdenum (Mo) are injurious to the body. Previous research has substantiated that Cd and Mo exposure caused testicular injury of ducks, but concrete mechanism is not fully clarified. To further survey the toxicity of co-exposure
Jiamei Zhu, Xueyan Dai, Yan Wang, Ting Cui, Bingyan Huang, Dianyun Wang, Wenjing Pu, Caiying Zhang   +7 more
doaj   +1 more source

Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di‐GMP‐Specific EAL Phosphodiesterases

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
The A526V substitution, previously not recognised to affect the functionality of the EAL domain, downregulates the apparent catalytic activity of the PAS‐GGDEF‐EAL ZMO1055 phosphodiesterase and other GGDEF‐EAL proteins. Substitution of A526, which is conserved among homologues, with amino acids with longer aliphatic side chains than valine, reverts to ...
Lian‐Ying Cao, Xue Zhang, Feng‐wu Bai, Ute Römling   +3 more
wiley   +1 more source

Carboxydotrophic Acetogenesis in Alkaline Conditions Results in Transient Formate Production by the Halo‐Alkaliphilic Acetogen Haloacetibacter carboxydivorans Gen. Nov. sp. Nov

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
This work presents the physiological exploration of the halo‐alkaliphilic, carboxydotrophic acetogen bacterium MD4. In contrast to well‐characterised neutrophilic and slightly acidophilic acetogenic carboxydotrophs, this work shows an important role for formate production, instead of ethanol, as a redox exhaust mechanism in alkaline conditions ...
Martijn Diender, Isabelle M. Keijsers, Anastasia Galani, Timo van Roosmalen, Alfons J. M. Stams, Diana Z. Sousa   +5 more
wiley   +1 more source