Results 161 to 170 of about 41,693 (219)

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress response

Redox Biology
Lung cancer cells are vulnerable to iron-dependent oxidation of phospholipids leading to ferroptosis, a process countered by glutathione peroxidase-4 that converts lipid hydroperoxides to lipid alcohols using glutathione as reducing agent.
Viktor Antonsson Garellick, Nadia Gul, Parvin Horrieh, Dyar Mustafa, Angana A.H. Patel, Martin Dankis, Samantha W. Alvarez, Johanna Berndtson, Saeed Mahdavi, Maria Schwarz, Andreas Persson, Fikret Zahirovic, Clotilde Wiel, Volkan I. Sayin, Per Lindahl   +14 more
doaj   +1 more source

Down regulation of glutathione and glutamate cysteine ligase in the inflammatory response of macrophages. [PDF]

Free Radic Biol Med, 2020
Zhang H, Zhang SJ, Lyn N, Florentino A, Li A, Davies KJA, Forman HJ.   +6 more
europepmc   +1 more source

Glutamate-cysteine ligase deficiency [PDF]

, 2020
openaire   +1 more source

Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress. [PDF]

Front Mol Biosci, 2020
Fu N, Li D, Li W, Zhao W, Zhang S, Liu L, Zhao S, Du J, Kong L, Wang R, Zhang Y, Nan Y.   +11 more
europepmc   +1 more source

Post-translational regulation and evolution of plant gamma-glutamate cysteine ligase

, 2007
Glutamate cysteine ligase (GCL) is catalyzing the rate-limiting step in glutathione (GSH) synthesis. A complex regulation of this enzyme is required to integrate various signals as GSH is fulfilling a plethora of functions in housekeeping metabolism, stress defence, and in the regulation of development.
openaire   +2 more sources

Glutamate-cysteine ligase as a diagnostic biomarker and therapeutic target in Parkinson's disease: a multi-omics and experimental study. [PDF]

Eur J Med Res
Li X, Wang M, Zhong C, Xia J, Tian L, Wang J, Yang D.   +6 more
europepmc   +1 more source

A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibility to ischemic stroke in the Chinese population. [PDF]

Eur J Med Res
Liao T, Weng YH, He J, Chen MR, Chen Y, Qi ZQ, Zhang ZM.   +6 more
europepmc   +1 more source

MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer. [PDF]

EMBO Rep, 2017
Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A.   +12 more
europepmc   +1 more source