Results 211 to 219 of about 41,693 (219)

Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase

Biochemical Pharmacology, 2007
Glutamate-cysteine ligase (GCL) is the rate-limiting enzyme in the glutathione (GSH) biosynthesis pathway. This enzyme is a heterodimer, comprising a catalytic subunit (GCLC) and a regulatory subunit (GCLM). Although GCLC alone can catalyze the formation of l-gamma-glutamyl-l-cysteine, its binding with GCLM enhances the enzyme activity by lowering the ...
Yi, Yang, Ying, Chen, Elisabet, Johansson, Scott N, Schneider, Howard G, Shertzer, Daniel W, Nebert, Timothy P, Dalton   +6 more
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4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells

Free Radical Biology and Medicine, 2002
Glutathione is the most abundant non-protein thiol in the cell, with roles in cell cycle regulation, detoxification of xenobiotics, and maintaining the redox tone of the cell. The glutathione content is controlled at several levels, the most important being the rate of de novo synthesis, which is mediated by two enzymes, glutamate cysteine ligase (GCL),
Dale A, Dickinson, Karen E, Iles, Nobuo, Watanabe, Takeo, Iwamoto, Hongqiao, Zhang, David M, Krzywanski, Henry Jay, Forman   +6 more
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Modulating GSH Synthesis Using Glutamate Cysteine Ligase Transgenic and Gene-Targeted Mice

Drug Metabolism Reviews, 2008
Glutathione (GSH) is an important antioxidant and cofactor for glutathione S-transferase conjugation. GSH synthesis is catalyzed by glutamate cysteine ligase (GCL), composed of catalytic (GCLC) and modifier (GCLM) subunits. Transgenic mice that conditionally over express GCL subunits are protected from acetaminophen induced liver injury. Gclm null mice
Dianne, Botta, Collin C, White, Portia, Vliet-Gregg, Isaac, Mohar, Shengli, Shi, Monica B, McGrath, Lisa A, McConnachie, Terrance J, Kavanagh   +7 more
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Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC)

Phytotherapy Research, 2007
AbstractThe extract of Ginkgo biloba (EGb), containing 24% flavone glycosides and 6% terpenoids, is widely used to treat early‐stage Alzheimer's disease, vascular dementia, peripheral claudication and vascular tinnitus. Its marked antioxidant activity has recently been demonstrated in both cell lines and animals.
Xiao-Ping, Liu, Christopher E P, Goldring, Hai-Yi, Wang, Ian M, Copple, Neil R, Kitteringham, B Kevin, Park, Wei, Wei   +6 more
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Glutamate Cysteine Ligase (GCL) Transgenic and Gene‐Targeted Mice for Controlling Glutathione Synthesis

Current Protocols in Toxicology, 2009
AbstractThe tripeptide glutathione (GSH) has important antioxidant properties, scavenges free radicals, and serves as a cofactor for glutathione S‐transferase conjugation of many xenobiotics. GSH is synthesized in two steps. The first and, often, rate‐limiting step is the formation of γ‐glutamylcysteine, which is catalyzed by the inducible ...
Isaac, Mohar, Dianne, Botta, Collin C, White, Lisa A, McConnachie, Terrance J, Kavanagh   +4 more
openaire   +2 more sources

Glutamate-Cysteine Ligase Catalytic Subunit

2020
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Glutamate-Cysteine Ligase Regulatory Subunit

2020
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Glutamate-Cysteine Ligase Modifier Knockout Mice

Science of Aging Knowledge Environment, 2002
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Glutamate-Cysteine Ligase Modifier Subunit Overexpression Confers Resistance Against Busulfan

2020
Gumrukcu, Serhat, Musikanth, Phillip A, Nguyen, Tung   +2 more
openaire   +1 more source