Results 31 to 40 of about 41,693 (219)

RBR E3 ubiquitin ligases: new structures, new insights, new questions [PDF]

, 2014
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes.
Shaw, Gary S., Spratt, Donald E., Walden, Helen   +2 more
core   +1 more source

Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors. [PDF]

Oncol Lett, 2018
Previous metabolomic analyses of cancer have revealed elevated glutathione levels in tumors. An inhibitor of cystine uptake was identified to suppress glutathione biosynthesis, leading to ferroptosis, a novel iron-dependent form of cell death that differs from apoptosis and necrosis.
Nishizawa S, Araki H, Ishikawa Y, Kitazawa S, Hata A, Soga T, Hara T.   +6 more
europepmc   +4 more sources

Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response. [PDF]

, 2016
Adipocytes promote cancer progression and impair treatment, and have been shown to protect acute lymphoblastic leukemia (ALL) cells from chemotherapies. Here we investigate whether this protection is mediated by changes in oxidative stress.
Behan, James W, Heisterkamp, Nora, Ji, Lingyun, Mittelman, Steven D, Parmentier, Jean-Hugues, Sheng, Xia, Tucci, Jonathan   +6 more
core   +1 more source

Environmental toxicity, redox signaling and lung inflammation:the role of glutathione [PDF]

, 2009
Glutathione (γ-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress.
Antonicelli, Aoki, Arfsten, Aruoma, Asti, Ault, Azzi, Bakin, Banhegyi, Banhegyi, Beck, Beeh, Beeh, Bindoli, Biswas, Borgstrom, Braga, Bridgeman, Bunnell, Burgunder, Butterworth, Cantin, Chakravarthi, Chan, Chan, Chen, Chen, Chuang, Church, Colombo, Cotgreave, Cotgreave, Crouch, Crystal, Das, De Benedetto, de Boer, De Caro, Decramer, Decramer, Dekhuijzen, Deleve, Dickinson, Dinkova-Kostova, Drost, Dueholm, Ekberg-Jansson, Erickson, Forman, Galloway, Gerrits, Gillissen, Grandjean, Grigg, Guidot, Haddad, Halliwell, Harju, Harper, Hayes, He, Holdiness, Huang, Hwang, Inci, Irfan Rahman, Ishibashi, Itoh, Janssen, Jardine, Jessop, Jeyapaul, Kang, Kasielski, Katayama, Kidd, Kim, Kinnula, Kinnula, Kinnula, Kinnula, Kobayashi, Kode, Koike, Komatsu, Krzywanski, Kwong, Lee, Lee, Lee, Leonard, Liu, Liu, Lomaestro, Lowry, Lu, Luppi, Mattes, McKone, Meister, Meyer, Miao, Monova, Moran, Moretti, Moretti, Mulcahy, Nakayama, Pacht, Paget, Park, Parmentier, Peltoniemi, Pietarinen-Runtti, Pinkus, Poole, Poole, Rahman, Rahman, Rahman, Rahman, Rahman, Rahman, Rahman, Rahman, Rasmusse, Reddy, Reynaert, Rhee, Roum, Rutkowski, Sadowska, Saibal K. Biswas, Shi, Shin, Siedlinski, Singh, Smith, Stey, Suter, Tanaka, Tian, Tirouvanziam, Tomonari, Trachootham, Tsikas, Tu, Usatyuk, Valko, van der Toorn, Van Schooten, Wakabayashi, Wang, White, Wild, Wood, Wood, Yang, Yang, Yang, Yeh, Zhang, Zhang   +162 more
core   +1 more source

Glutathione in Cancer Cell Death [PDF]

, 2011
Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; and cell proliferation
Ames, Angel L. Ortega, Arai, Armstrong, Armstrong, Arrick, Arrigo, Azad, Baguley, Baines, Balendiran, Ballatori, Beatrice, Bedikian, Benlloch, Benlloch, Bignold, Biswas, Borst, Boveris, Brdiczka, Brosnan, Bump, Burcham, Calvert, Carrascosa, Carretero, Carretero, Cazanave, Chanas, Chen, Chen, Cheung, Circu, Cole, Conway, Costantini, Costantini, Crook, D'Alessio, Dalton, Dalton, Dang, de Bruin, DeBerardinis, DeGraff, Depeille, Dethmers, Dias, Dickinson, Ekshyyan, Erickson, Estrela, Estrela, Federico, Franco, Franco, Franco, Franco, Friesen, Fulda, Gadsby, Gatti, Gjertsen, Gleave, Gogvadze, Goossens, Gottesman, Guha, Guha, Halestrap, Hall, Hall, Halliwell, Halliwell, Hanigan, Hansen, Hara, Harper, Hayes, Hidalgo, Higuchi, Higuchi, Hochwald, Honda, Ischiropoulos, Janssen-Heininger, Jones, Jose M. Estrela, Kang, Kensler, Keppler, Klaassen, Klasa, Klimberg, Klimberg, Klionsky, Kokoszka, Kowaltowski, Krauskopf, Krebs, Kretz-Remy, Kroemer, Kroemer, Kuhn, Kuo, Kuranaga, Lai, Lee, Leslie, Leslie, Levine, Linsdell, Loe, Loe, Lopes de Menezes, Lorico, Loschen, Lu, Lu, Maher, McDonald, Medina, Meister, Meister, Melis, Mena, Mena, Mieyal, Mistry, Mitchell, Miyake, Morales, Moreira, Morito, Moscow, Nguyen, Obrador, Obrador, Obrador, Ortega, Ortega, Paget, Park, Parmentier, Pastor, Pennington, Petronilli, Priego, Rahman, Rappa, Rebrin, Reisman, Salvador Mena, Savarese, Scherz-Shouval, Schneider, Shacter, Son, Song, Stole, Suthanthiran, Szabo, Terasaki, Terradez, Tormos, Troyano, Um, Usatyuk, Valko, Versantvoort, Wang, Warburg, Wijnholds, Wild, Wise, Wise, Yao, Yuan, Zaman, Zangemeister-Wittke, Zhang, Zhou, Ziegler, Zong   +184 more
core   +2 more sources

Anti-oxidant and anti-inflammatory activity of ketogenic diet. New perspectives for neuroprotection in alzheimer’s disease [PDF]

, 2018
The ketogenic diet, originally developed for the treatment of epilepsy in non-responder children, is spreading to be used in the treatment of many diseases, including Alzheimer’s disease.
Bonucci, Alessio, Businaro, Rita, Corsi, Mariangela, Maggi, Elisa, Pinto, Alessandro   +4 more
core   +1 more source

Expression and Characterization of Human Glutamate–Cysteine Ligase

Archives of Biochemistry and Biophysics, 1998
Glutamate-cysteine ligase (GLCL) catalyzes the rate-limiting step in glutathione biosynthesis. GLCL comprises regulatory (GLCLR) and catalytic (GLCLC) subunits. To understand better the structure-function relationship of GLCL subunits and holoenzyme, human GLCLR and GLCLC genes were inserted into the baculovirus genome.
Z, Tu, M W, Anders
openaire   +2 more sources

Overexpression of Glutamate-Cysteine Ligase Extends Life Span in Drosophila melanogaster [PDF]

Journal of Biological Chemistry, 2005
The hypothesis that overexpression of glutamate-cysteine ligase (GCL), which catalyzes the rate-limiting reaction in de novo glutathione biosynthesis, could extend life span was tested in the fruit fly, Drosophila melanogaster. The GAL4-UAS binary transgenic system was used to generate flies overexpressing either the catalytic (GCLc) or modulatory ...
William C, Orr, Svetlana N, Radyuk, Leena, Prabhudesai, Dikran, Toroser, Judith J, Benes, James M, Luchak, Robin J, Mockett, Igor, Rebrin, J Gregory, Hubbard, Rajindar S, Sohal   +9 more
openaire   +2 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Urinary felinine excretion in intact male cats is increased by dietary cystine [PDF]

, 2008
Felinine is a branched-chain sulfur amino acid present in the urine of certain Felidae, including domestic cats. The objective of the present study was to determine if additional cystine and/or dietary N would increase felinine and N-acetylfelinine ...
Hendriks, W.H., Morton, R.H., Rogers, Q.R., Rutherfurd-Markwick, K.J., Weidgraaf, K.   +4 more
core   +2 more sources