The Role of Glutamate Receptors in Epilepsy [PDF]
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
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The role of glutamate receptors in the regulation of the tumor microenvironment [PDF]
Frontiers in Immunology, 2023 Glutamate, as one of the most important carbon sources in the TCA cycle, is central in metabolic processes that will subsequently influence tumor progression.
Stephane Koda +8 more
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Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in
BMC Biology, 2005 Background Drosophila discs-large (DLG) is the sole representative of a large class of mammalian MAGUKs, including human DLG, SAP 97, SAP102, and PSD-95. MAGUKs are thought to be critical for postsynaptic assembly at glutamatergic synapses.
Featherstone David E, Chen Kaiyun
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Cross-talk and regulation between glutamate and GABAB receptors [PDF]
Frontiers in Cellular Neuroscience, 2015 Brain function depends on co-ordinated transmission of signals from both excitatory and inhibitory neurotransmitters acting upon target neurons.
Sriharsha eKantamneni
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High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]
Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016 NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
Scheppach, Christian
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An Insight into Animal Glutamate Receptors Homolog of Arabidopsis thaliana and Their Potential Applications—A Review [PDF]
Plants, 2022 Most excitatory impulses received by neurons are mediated by ionotropic glutamate receptors (iGluRs). These receptors are located at the apex and play an important role in memory, neuronal development, and synaptic plasticity.
Ruphi Naz +7 more
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A Review of Molecular Imaging of Glutamate Receptors
Molecules, 2020 Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) is a well-established and important in vivo technique to evaluate fundamental biological processes and unravel the role of neurotransmitter ...
Jong-Hoon Kim +3 more
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Researching glutamate – induced cytotoxicity in different cell lines: a comparative/, collective analysis/study [PDF]
Frontiers in Cellular Neuroscience, 2015 Although glutamate is one of the most important excitatory neurotransmitters of the central nervous system, its excessive extracellular concentration leads to uncontrolled continuous depolarization of neurons, a toxic process called, excitotoxicity.
Aristeidis eKritis +3 more
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Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors
Frontiers in Molecular Neuroscience, 2015 Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, by the insertion or removal of AMPA-type glutamate receptors at the postsynaptic membrane of excitatory synapses.
Marisa S Goo +2 more
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Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors
Frontiers in Molecular Neuroscience, 2019 Pain is an essential protective mechanism meant to prevent tissue damages in organisms. On the other hand, chronic or persistent pain caused, for example, by inflammation or nerve injury is long lasting and responsible for long-term disability in ...
Vanessa Pereira, Cyril Goudet
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