Results 211 to 220 of about 65,396 (291)

An Efficient CO2‐Upcycling Platform Based on Engineered Halomonas TD with Enhanced Acetate‐Utilizing Capacity via Adaptive Laboratory Evolution

Advanced Science, EarlyView.
An electrochemical system is designed to convert CO2 into CO2‐derived electrolytes (CDE), mainly containing acetate and formate. The underlying mechanism of acetate metabolism in Halomonas TD80 is explored via ALE. Engineered TD80 produced high‐yield diversified products from CDE.
Chi Wang, Ting‐Ting Chen, Yu‐Jiao Yang, Yu‐Xi Li, Yi‐Xin Chang, Yan‐Chun Xiao, Wen‐Tai Guo, Ye Zheng, Rui‐Zhe Deng, Yu‐Xiang Tian, Wei Situ, Hong‐Wei Shen, Yu Chen, Ya‐Bin Wang, Jie Xing, Hui Wang, Lin Xia, Yi‐Na Lin, Jian‐Wen Ye   +18 more
wiley   +1 more source

Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5. [PDF]

Nat Commun
Li M, Lan X, Shi X, Zhu C, Lu X, Pu J, Lu S, Zhang J.   +7 more
europepmc   +1 more source

Physiological and metabolic effects of a transposon-mediated mutation in the glutamate synthase gene, gltB, of plant-beneficial, cytokinin-producing Pseudomonas hormoni G20-18T

Ajay M. Sorty, Athanasios Zervas, Vaidotas Kisielius, Chandana Pandey, Rosanna C. Hennessy, Tue Kjærgaard Nielsen, Pedro N. Carvalho, Thomas Roitsch, Peter Stougaard   +8 more
openalex   +1 more source

Molecular cloning of the yeast mitochondrial aconitase gene (ACO1) and evidence of a synergistic regulation of expression by glucose plus glutamate.

, 1990
Serge Gangloff, Didier Marguet, Guy J.‐M. Lauquin   +2 more
openalex   +2 more sources

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

Advanced Science, EarlyView.
Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
wiley   +1 more source

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes. [PDF]

Angew Chem Int Ed Engl
Neißner K, Duchardt-Ferner E, Wiedemann C, Kraus J, Hellmich UA, Wöhnert J.   +5 more
europepmc   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Mechanistic insights into TTLL11 polyglutamylase-mediated primary tubulin chain elongation. [PDF]

Sci Adv
Campbell J, Vosahlikova M, Ismail S, Volnikova M, Motlova L, Kudlacova J, Ustinova K, Snajdr I, Novakova Z, Basta M, Gutsche I, Moutin MJ, Desfosses A, Barinka C.   +13 more
europepmc   +1 more source

A common variant in the 3′UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder

, 2008
Ben Pickard, Helen Miranda Knight, Russell S. Hamilton, Dinesh C. Soares, Robert Walker, J. K. F. Boyd, J. Machell, Alan Maclean, Kevin A. McGhee, Alison Condie, David J. Porteous, David St Clair, Ilan Davis, Douglas Blackwood, Walter Muir   +14 more
openalex   +2 more sources

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source