Results 211 to 220 of about 221,194 (241)
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Genotoxicity of monosodium glutamate
Food and Chemical Toxicology, 2016Monosodium glutamate (MSG) is one of the most widely used flavor enhancers throughout the world. The aim of this study is to investigate the genotoxic potential of MSG by using chromosome aberrations (CAs), sister-chromatid exchanges (SCEs), cytokinesis-blocked micronucleus (CBMN), and random amplified polymorphic DNA-polimerase chain reaction (RAPD ...
Ataseven, Nazmiye +3 more
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, 2008
Zn-chelated glycine ester enolates are highly efficient nucleophiles for the synthesis of conformationally constrained glutamates via domino sequences of Michael additions and subsequent ring closures (MIRC).
C. Schmidt, U. Kazmaier
semanticscholar +1 more source
Zn-chelated glycine ester enolates are highly efficient nucleophiles for the synthesis of conformationally constrained glutamates via domino sequences of Michael additions and subsequent ring closures (MIRC).
C. Schmidt, U. Kazmaier
semanticscholar +1 more source
Current Pharmaceutical Design, 2012
Increasing evidence suggests that abnormalities in glutamatergic transmission may be associated with psychosis risk. Genetic polymorphisms associated with schizophrenia converge on NMDA receptor signalling pathways, and transgenic animal models and human neuroimaging studies have shown the functional impact of these risk alleles.
Egerton, Alice +2 more
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Increasing evidence suggests that abnormalities in glutamatergic transmission may be associated with psychosis risk. Genetic polymorphisms associated with schizophrenia converge on NMDA receptor signalling pathways, and transgenic animal models and human neuroimaging studies have shown the functional impact of these risk alleles.
Egerton, Alice +2 more
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Homopolypeptides derived from substituted β-Benzyl-L-aspartates and γ-Benzyl-L-glutamates
, 1966Homopolypeptides have been obtained by polymerization of the N-carboxy anhydrides of various substituted β-benzyl-L-aspartates and γ-benzyl-L- glutamates.
R. Ledger, F. Stewart
semanticscholar +1 more source
2002
The toxic effects of glutamate exposure on neurons were first recognized nearly half a century ago, when Lucas and Newhouse observed that subcutaneous administration of glutamate caused loss of neurons in the inner nuclear layer of the retina in both adult and neonatal mice (1). Olney extended these findings to other regions of brain, including neurons
Dennis W. Choi, B. Joy Snider
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The toxic effects of glutamate exposure on neurons were first recognized nearly half a century ago, when Lucas and Newhouse observed that subcutaneous administration of glutamate caused loss of neurons in the inner nuclear layer of the retina in both adult and neonatal mice (1). Olney extended these findings to other regions of brain, including neurons
Dennis W. Choi, B. Joy Snider
openaire +2 more sources
Convenient Preparation of α-Tert-Butyl N-Blocked Glutamates Through γ-Allyl Ester Protection
, 1995Utilisation of γ-allyl ester protection of glutamates provides a convenient route to the synthesis of Z-Glu-OBut, Tr-Glu-OBut and (Boc)2-Glu-OBut.
V. Bavetsias, G. Bisset, M. Jarman
semanticscholar +1 more source
Hippocampal glutamate receptors
Molecular and Cellular Biochemistry, 1981For years, the hippocampus has been the privileged domain of anatomists and electrophysiologists for investigating various neurobiological processes. The present review deals with recent work which shows that this structure is also well suited to study the role of glutamate as a neurotransmitter and more particularly the characteristics of glutamate ...
Gary Lynch, Michel Baudry
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Progress in Neurobiology, 2001
Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to glutamate transporter proteins present in the plasma membranes of both glial cells and neurons. The transporter proteins represent the only (significant) mechanism for removal of glutamate from the extracellular fluid and their importance for the long-term maintenance
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Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to glutamate transporter proteins present in the plasma membranes of both glial cells and neurons. The transporter proteins represent the only (significant) mechanism for removal of glutamate from the extracellular fluid and their importance for the long-term maintenance
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2012
Orexin neurons are localized in the lateral hypothalamus and regulate many functions including sleep-wake states. Substantial number of neurotransmitters and neuromodulators has been proposed to influence orexinergic system. Glutamate, as the major excitatory amino acid neurotransmitter in the hypothalamus, was shown to mediate orexin neurons in the ...
Minbay, Zehra +2 more
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Orexin neurons are localized in the lateral hypothalamus and regulate many functions including sleep-wake states. Substantial number of neurotransmitters and neuromodulators has been proposed to influence orexinergic system. Glutamate, as the major excitatory amino acid neurotransmitter in the hypothalamus, was shown to mediate orexin neurons in the ...
Minbay, Zehra +2 more
openaire +3 more sources
Glutamate oxidation in astrocytes: Roles of glutamate dehydrogenase and aminotransferases
Journal of Neuroscience Research, 2016The cellular distribution of transporters and enzymes related to glutamate metabolism led to the concept of the glutamate–glutamine cycle. Glutamate is released as a neurotransmitter and taken up primarily by astrocytes ensheathing the synapses. The glutamate carbon skeleton is transferred back to the presynaptic neurons as the nonexcitatory amino acid
McKenna, Mary C +5 more
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