Results 41 to 50 of about 221,194 (241)
Journal of Biological Chemistry, 1997 Hydrogen ions reduce ion flux through voltage-gated Ca2+ channels by binding to a single protonation site with an unusually high pK a . Recent evidence localizes the protonation site to the same locus that supports high affinity Ca2+ binding and ...
Xiao-hua Chen, R. Tsien
semanticscholar +1 more source
Frontiers in Endocrinology, 2013 The system N transporter SN1 (also known as SNAT3) is enriched on perisynaptic astroglial cell membranes. SN1 mediates electroneutral and bidirectional glutamine transport, and regulates the intracellular as well as the extracellular concentrations of ...
Lise Sofie H. Nissen-Meyer +1 more
doaj +1 more source
Life without glutamate: the epigenetic effects of glutamate deletion [PDF]
Frontiers in Molecular Neuroscience, 2014 Li et al. (2013) studied ThVGdKO mice produced by genetic elimination of the genes for both vesicular transporters Vglut-1 and Vglut-2. In these mice thalamocortical glutamate neurotransmission in somatosensory cortex (but not in visual or auditory cortex) is silenced or knocked-out, thereby disabling the release of glutamate from synaptic vesicles ...
John Smythies +2 more
openaire +4 more sources
Amantadine in the treatment of Pathological Gambling: a case report
Frontiers in Psychiatry, 2012 Despite almost a decade of intense research, effective treatment strategies for Pathological Gambling (PG) remain very challenging. This paper details a case report suggesting that the treatment of PG may benefit from the use of the non-specific ...
Mauro ePettorruso +6 more
doaj +1 more source
Mutational and structural analyses of Caldanaerobius polysaccharolyticus Man5B reveal novel active site residues for family 5 glycoside hydrolases. [PDF]
PLoS ONE, 2013 CpMan5B is a glycoside hydrolase (GH) family 5 enzyme exhibiting both β-1,4-mannosidic and β-1,4-glucosidic cleavage activities. To provide insight into the amino acid residues that contribute to catalysis and substrate specificity, we solved the ...
Takuji Oyama +9 more
doaj +1 more source
Glutamate-induced Exocytosis of Glutamate from Astrocytes
Journal of Biological Chemistry, 2007 Recent studies indicate that astrocytes can play a much more active role in neuronal circuits than previously believed, by releasing neurotransmitters such as glutamate and ATP. Here we report that local application of glutamate or glutamine synthetase inhibitors induces astrocytic release of glutamate, which activates a slowly decaying transient ...
Jane H.-C. Lin +6 more
openaire +3 more sources
Molecules, 2018 Despite notable progress, the fabrication of well-defined polypeptides via controlled ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) using convenient catalysts under mild conditions in a relatively short polymerization time ...
Yanzhao Nie +3 more
doaj +1 more source
Quantitative peptidomics of Purkinje cell degeneration mice. [PDF]
PLoS ONE, 2013 Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-chain glutamates from tubulin. The Purkinje cell degeneration (pcd) mouse lacks CCP1 due to a mutation.
Iryna Berezniuk +6 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1985 A methotrexate (MTX) analog containing fluorine at the gamma-carbon of the glutamate moiety, gamma-fluoromethotrexate (FMTX), has been synthesized and evaluated for its biochemical and pharmacological properties.
J. Galivan +4 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2012 Mechanical loading plays a key role in the physiology of bone, allowing bone to functionally adapt to its environment, however characterization of the signaling events linking load to bone formation is incomplete. A screen for genes associated with mechanical load-induced bone formation identified the glutamate transporter GLAST, implicating the ...
Deborah Jane Mason +1 more
openaire +4 more sources