Results 41 to 50 of about 226,163 (382)
Glutamate transporter control of ambient glutamate levels
Neurochemistry International, 2014 Accurate knowledge of the ambient extracellular glutamate concentration in brain is required for understanding its potential impacts on tonic and phasic receptor signaling. Estimates of ambient glutamate based on microdialysis measurements are generally in the range of ∼2-10μM, approximately 100-fold higher than estimates based on electrophysiological ...
Weinan Sun +3 more
openaire +3 more sources
Journal of Obesity & Metabolic SyndromeBackground : Remote ischemic postconditioning (RIPostC) may protect the brain from ischemia/reperfusion (I/R) injury. The association between RIPostC and obesity has not yet been extensively studied.
Klaudia Kotorová +4 more
doaj +1 more source
Selecting Ions by Size in a Calcium Channel: The Ryanodine Receptor Case Study [PDF]
, 2014 Many calcium channels can distinguish between ions of the same charge but different size. For example, when cations are in direct competition with each other, the ryanodine receptor (RyR) calcium channel preferentially conducts smaller cations such as Li+
Gillespie, Dirk +2 more
core +2 more sources
Pharmacotherapy of Schizophrenia: Ploypharmacy Approaches [PDF]
Acta Medica Iranica, 2010 "nSchizophrenia is a debilitating illness, rating as one of the leading causes of lost years of quality of life. The illness imposes a disproportionate burden on patients and their families, healthcare systems and society. Pharmacological management
Fatemeh Rahiminejad, Shahin Akhondzadeh
doaj +2 more sources
Beyond Sulfate-Free Personal Cleansing Technology
CosmeticsThere is a strong global demand for sulfate-free personal cleansing products. The objective of sulfate-free personal cleansing technology should not be aimed solely at the absence of “sulfate” wording in the list of ingredients, but on the true benefits ...
Evelyn Su, Stephen Herman
doaj +1 more source
Biological Procedures Online, 2004 In synaptic vesicles, the estimated concentration of the excitatory amino acid glutamate is 100-150 mM. It was recently discovered that VGLUT1, previously characterized as an inorganic phosphate transporter (BNPI) with 9-11 predicted transmembrane ...
Andersen Søren S.L.
doaj +1 more source
Biodegradable polymeric prodrugs of naltrexone [PDF]
, 1991 The development of a biodegradable polymeric drug delivery system for the narcotic antagonist naltrexone may improve patient compliance in the treatment of opiate addiction. Random copolymers consisting of the ¿-amino acids N5-(3-hydroxypropyl--glutamine
Adams, N.W. +5 more
core +2 more sources
Biochemical and Biophysical Research Communications - BBRC, 1994 Mammalian metallothioneins (MTs) possess eight highly conserved lysine residues, including three in each of two metal binding domains. We used site-directed mutagenesis to replace these intradomain lysines in Chinese hamster ovary MT2 with glutamic acid ...
C. Cody, P. C. Huang
semanticscholar +1 more source
Cortical glutamate in migraine [PDF]
Brain, 2017 Cortical hyperexcitability due to enhanced glutamatergic activity has been implicated in migraine pathophysiology but direct evidence is lacking. Here we assessed glutamate levels and intracellular mobility of glutamate in the visual cortex of migraineurs in-between attacks.
Mark C. Kruit +9 more
openaire +5 more sources
Evaluation of Phage Display Discovered Peptides as Ligands for Prostate-Specific Membrane Antigen (PSMA) [PDF]
, 2013 The aim of this study was to identify potential ligands of PSMA suitable for further development as novel PSMA-targeted peptides using phage display technology. The human PSMA protein was immobilized as a target followed by incubation with a 15-mer phage
A Ghosh +48 more
core +7 more sources