Results 41 to 50 of about 226,956 (383)

Diversity of Fe2+ entry and oxidation in ferritins [PDF]

, 2017
The essential metal iron presents two major problems for life: it is potentially highly toxic due to its redox activity, and its extremely low solubility in aqueous solution in the presence of O2 can make it hard to acquire and store safely.
Bradley, Justin M., Le Brun, Nick E., Moore, Geoffrey R.   +2 more
core   +1 more source

Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases

Frontiers in Molecular Neuroscience, 2022
The natriuretic peptide receptors NPR1 and NPR2, also known as guanylyl cyclase A and guanylyl cyclase B, have critical functions in many signaling pathways, but much remains unknown about their localization and function in vivo. To facilitate studies of
Jeremy R. Egbert, Tracy F. Uliasz, Katie M. Lowther, Katie M. Lowther, Deborah Kaback, Deborah Kaback, Brandon M. Wagner, Chastity L. Healy, Timothy D. O’Connell, Lincoln R. Potter, Lincoln R. Potter, Laurinda A. Jaffe, Siu-Pok Yee, Siu-Pok Yee   +13 more
doaj   +1 more source

Selecting Ions by Size in a Calcium Channel: The Ryanodine Receptor Case Study [PDF]

, 2014
Many calcium channels can distinguish between ions of the same charge but different size. For example, when cations are in direct competition with each other, the ryanodine receptor (RyR) calcium channel preferentially conducts smaller cations such as Li+
Gillespie, Dirk, Xu, Le, Meissner, Gerhard   +2 more
core   +2 more sources

Pharmacotherapy of Schizophrenia: Ploypharmacy Approaches [PDF]

Acta Medica Iranica, 2010
"nSchizophrenia is a debilitating illness, rating as one of the leading causes of lost years of quality of life. The illness imposes a disproportionate burden on patients and their families, healthcare systems and society. Pharmacological management
Fatemeh Rahiminejad, Shahin Akhondzadeh
doaj   +2 more sources

Beyond Sulfate-Free Personal Cleansing Technology

Cosmetics
There is a strong global demand for sulfate-free personal cleansing products. The objective of sulfate-free personal cleansing technology should not be aimed solely at the absence of “sulfate” wording in the list of ingredients, but on the true benefits ...
Evelyn Su, Stephen Herman
doaj   +1 more source

Expression and purification of recombinant vesicular glutamate transporter VGLUT1 using PC12 cells and High Five insect cells

Biological Procedures Online, 2004
In synaptic vesicles, the estimated concentration of the excitatory amino acid glutamate is 100-150 mM. It was recently discovered that VGLUT1, previously characterized as an inorganic phosphate transporter (BNPI) with 9-11 predicted transmembrane ...
Andersen Søren S.L.
doaj   +1 more source

Replacement of all alpha-domain lysines with glutamates reduces metallothionein detoxification function.

Biochemical and Biophysical Research Communications - BBRC, 1994
Mammalian metallothioneins (MTs) possess eight highly conserved lysine residues, including three in each of two metal binding domains. We used site-directed mutagenesis to replace these intradomain lysines in Chinese hamster ovary MT2 with glutamic acid ...
C. Cody, P. C. Huang
semanticscholar   +1 more source

Cortical glutamate in migraine [PDF]

Brain, 2017
Cortical hyperexcitability due to enhanced glutamatergic activity has been implicated in migraine pathophysiology but direct evidence is lacking. Here we assessed glutamate levels and intracellular mobility of glutamate in the visual cortex of migraineurs in-between attacks.
Mark C. Kruit, Michel D. Ferrari, Hermien E. Kan, Jannie P. Wijnen, Jannie P. Wijnen, Itamar Ronen, Andrew G. Webb, Gisela M. Terwindt, Ronald Zielman, Gerrit L J Onderwater   +9 more
openaire   +5 more sources

Biodegradable polymeric prodrugs of naltrexone [PDF]

, 1991
The development of a biodegradable polymeric drug delivery system for the narcotic antagonist naltrexone may improve patient compliance in the treatment of opiate addiction. Random copolymers consisting of the ¿-amino acids N5-(3-hydroxypropyl--glutamine
Adams, N.W., Bennet, D.B., Feijen, J., Hoes, C.J.T., Kim, S.W., Li, X.   +5 more
core   +2 more sources

Obesity as a Limiting Factor for Remote Ischemic Postconditioning-Mediated Neuroprotection after Stroke

Journal of Obesity & Metabolic Syndrome
Background : Remote ischemic postconditioning (RIPostC) may protect the brain from ischemia/reperfusion (I/R) injury. The association between RIPostC and obesity has not yet been extensively studied.
Klaudia Kotorová, Jana Končeková, Miroslav Gottlieb, Martin Bona, Petra Bonová   +4 more
doaj   +1 more source