Results 51 to 60 of about 226,163 (382)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Cofactor Tail Length Modulates Catalysis of Bacterial F420-Dependent Oxidoreductases

Frontiers in Microbiology, 2017
F420 is a microbial cofactor that mediates a wide range of physiologically important and industrially relevant redox reactions, including in methanogenesis and tetracycline biosynthesis.
Blair Ney, Blair Ney, Carlo R. Carere, Richard Sparling, Richard Sparling, Thanavit Jirapanjawat, Matthew B. Stott, Colin J. Jackson, John G. Oakeshott, Andrew C. Warden, Chris Greening, Chris Greening   +11 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Biochemical characterization of mutants in the active site residues of the β-galactosidase enzyme of Bacillus circulans ATCC 31382

FEBS Open Bio, 2014
The Bacillus circulans ATCC 31382 β-galactosidase (BgaD) is a retaining-type glycosidase of glycoside hydrolase family 2 (GH2). Its commercial enzyme preparation, Biolacta N5, is used for commercial-scale production of galacto-oligosaccharides (GOS). The
Jelle B. Bultema, Bas J.H. Kuipers, Lubbert Dijkhuizen   +2 more
doaj   +1 more source

Direct visualization reveals dynamics of a transient intermediate during protein assembly [PDF]

, 2011
Interactions between proteins underlie numerous biological functions. Theoretical work suggests that protein interactions initiate with formation of transient intermediates that subsequently relax to specific, stable complexes.
Alberts, Boehr, Comeau, Crane, Crowley, Egea, Estrozi, Focia, Harel, J. Chung, J. R. Winkler, Janin, Jones, Koshland, Levy, Ma, Pande, Papoian, Papoian, S. Chandrasekar, S. L. Mayo, S.-o. Shan, Schreiber, Schreiber, Schreiber, T. Kimura, Tang, Ubbink, V. Q. Lam, Vijayakumar, Wolynes, X. Zhang, Xu, Y. Mou, Zhang, Zhang   +35 more
core   +3 more sources

Glutamate Receptor [PDF]

, 2016
[No abstract]
openaire   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype

Frontiers in Cellular Neuroscience, 2015
The role of glutamate N-methyl-D-Aspartate receptor (NMDAR) hypofunction has been extensively studied in schizophrenia; however, less is known about its role in anxiety disorders.
Eduardo R Zimmer, Vitor R Torrez, Eduardo eKalinine, Eduardo eKalinine, Marina C Augustin, Kamila C Zenki, Roberto Farina Almeida, Gisele eHansel, Alexandre P Muller, Diogo O Souza, Rodrigo eMachado-Vieira, Rodrigo eMachado-Vieira, Luis V Portela   +12 more
doaj   +1 more source

Mutational and structural analyses of Caldanaerobius polysaccharolyticus Man5B reveal novel active site residues for family 5 glycoside hydrolases. [PDF]

PLoS ONE, 2013
CpMan5B is a glycoside hydrolase (GH) family 5 enzyme exhibiting both β-1,4-mannosidic and β-1,4-glucosidic cleavage activities. To provide insight into the amino acid residues that contribute to catalysis and substrate specificity, we solved the ...
Takuji Oyama, George E Schmitz, Dylan Dodd, Yejun Han, Alanna Burnett, Naoko Nagasawa, Roderick I Mackie, Haruki Nakamura, Kosuke Morikawa, Isaac Cann   +9 more
doaj   +1 more source

Energetics of ion competition in the DEKA selectivity filter of neuronal sodium channels [PDF]

, 2015
The energetics of ionic selectivity in the neuronal sodium channels is studied. A simple model constructed for the selectivity filter of the channel is used.
Boda, D., Eisenberg, B., Fonseca, J., Leaf, G.   +3 more
core   +4 more sources