Results 91 to 100 of about 538,260 (299)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Exploration of the Full Conformational Space of N-Acetyl-l-glutamine-N-methylamide. An ab Initio and Density Functional Theory Study

, 2016
The full conformational space of N-acetyl-l-glutamine-N-methylamide was explored by ab initio (RHF/3-21G and RHF/6-31G(d)) and DFT (B3LYP/6-31G(d)) computations.
Ricardo D. Enriz (730877), Marco W. Klipfel (3052056), Noemí G. Fidanza (3052050), Imre G. Csizmadia (455856), Ana M. Rodriguez (3052053), Miguel A. Zamora (3052059)   +5 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effect of Oral Glutamine on Patient Outcomes following Open Heart Surgery: A Double Blind Clinical Trial

Journal of Mazandaran University of Medical Sciences, 2019
Background and purpose: Cardiovascular diseases are the most common cause of death worldwide. Surgical treatment is one of the main treatment options for cardiac diseases.
Gohar Eslami, Rahman Ghafari, Valiollah Habibi, Aria Soleimani, Jamshid Yazdani Charati, Hasti Sadraei, Shahaboddin Emami, Majid Javanmard   +7 more
doaj  

Response of glutamine metabolism to glutamine-supplemented parenteral nutrition

, 2000
Increasing evidence suggests that glutamine is important for the function of many organ systems and supports the use of glutamine-enriched total parenteral nutrition (TPN) during severe illness.
von Meyenfeldt, M.F., Peter B Soeters, van Acker, B.A.C., Anton JM Wagenmakers, Wagenmakers, A.J.M., Karel WE Hulsewé, Maarten F von Meyenfeldt, Soeters, P.B., Bernadette AC van Acker, Hulsewé, K.W.E.   +9 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Supplementation of L-glutamine enhanced mucosal immunity and improved hormonal status of combat-sport athletes

Journal of the International Society of Sports Nutrition
Background Maintaining proper immune function and hormone status is important for athletes to avoid upper respiratory tract infection (URTI) and insufficient recovery, which is detrimental to sport performance and health.
Tung-Lin Lu, Ai-Chi Zheng, Katsuhiko Suzuki, Chi-Cheng Lu, Chung-Yuan Wang, Shih-Hua Fang   +5 more
doaj   +1 more source

Coagulation Factor XIIIa Undergoes a Conformational Change Evoked by Glutamine Substrate

, 2023
Coagulation factor XIIIa, plasma transglutaminase(endo-g-glutamine:e-lysine transferase EC 2.3.2.13) cata-lyzes isopeptide bond formation between glutamine andlysine residues and rapidly cross-links fibrin clots.
Mitkevich, Olga, Smejkal, Gary B., Yee, Vivian, Teller, David C., Samokhin, Gennady P., NC DOCKS at East Carolina University, Shainoff, John R., Bishop, Paul D.   +7 more
core  

Experimental Cancer Cachexia Changes Neuron Numbers and Peptide Levels in the Intestine: Partial Protective Effects after Dietary Supplementation with L-Glutamine. [PDF]

, 2016
Gastrointestinal dysmotility frequently occurs in cancer cachexia and may result from damage to enteric innervation caused by oxidative stress, especially due to glutathione depletion.
Flávia A Guarnier, Flávia A. Guarnier (3124257), Luciane Fracaro (3124248), Jacqueline N. Zanoni (3124260), Sara R G de Souza, Heber A Martins, Jacqueline N Zanoni, Geraldo E. Vicentini (3124245), Geraldo E Vicentini, Sara R. G. de Souza (3124254), Heber A. Martins (3124251), Luciane Fracaro   +11 more
core   +1 more source