Results 71 to 80 of about 538,260 (299)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Human SLC1A5 Neutral Amino Acid Transporter Catalyzes a pH-Dependent Glutamate/Glutamine Antiport, as Well

Frontiers in Cell and Developmental Biology, 2020
ASCT2 is a neutral amino acid transporter, which catalyzes a sodium-dependent obligatory antiport among glutamine and other neutral amino acids. The human ASCT2 over-expressed in Pichia pastoris and reconstituted in proteoliposomes has been employed for ...
Mariafrancesca Scalise, Tiziano Mazza, Gilda Pappacoda, Lorena Pochini, Jessica Cosco, Filomena Rovella, Cesare Indiveri, Cesare Indiveri   +7 more
doaj   +1 more source

Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy

Pharmaceuticals, 2021
Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids that can be produced in our body. However, they are essential for the growth of highly proliferative cells such as cancers.
Macus Tien Kuo, Helen H. W. Chen, Lynn G. Feun, Niramol Savaraj   +3 more
doaj   +1 more source

The differential expression of the genes encoding glutamine synthetase in developing root modules [PDF]

, 1990
Glutamine synthetase (GS) is one of the key enzymes involved in the assimilation of ammonia into organic nitrogen in plants. It is important in legume root nodules where ammonia, produced by the Rhizobium-legume symbiosis, is converted to organic ...
Teverson, Rachel
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer

The EMBO Journal
Triple-negative breast cancer (TNBC) metabolism and cell growth uniquely rely on glutamine uptake by the transporter ASCT2. Despite previous data reporting cell growth inhibition after ASCT2 knockdown, we here show that ASCT2 CRISPR knockout is tolerated
Kanu Wahi, Natasha Freidman, Qian Wang, Michelle Devadason, Lake-Ee Quek, Angel Pang, Larissa Lloyd, Mark Larance, Fabio Zanini, Kate Harvey, Sandra O’Toole, Yi Fang Guan, Jeff Holst   +12 more
doaj   +1 more source

Measurement of glutathione synthesis by isotope ratio mass spectrometry in systemic inflammation [PDF]

, 2010
During sepsis and critical illness, a systemic inflammatory response can significantly produce reactive oxygen and nitrogen species, which can damage host tissues.
Kimura, Y.
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

MYC regulation of Glutamine-Proline regulatory axis is key in Luminal B breast cancer [PDF]

, 2017
Background: Altered cellular metabolism is a hallmark of cancer and some are reliant on Glutamine for sustained proliferation and survival. We hypothesise that the Glutamine-Proline regulatory axis has a key role in Breast cancer (BC) in the highly ...
Natasha Jewa, Cheung, H., Daniele Soria, Coimbra, N.D.M., Ian O Ellis, Rakha, Emad, Jewa, Natasha, Soria, Daniele, Madeleine L Craze, Jewa, N., Green, Andrew R., Diez-Rodriguez, M., Emad A Rakha, Diez-Rodriguez, Maria, Aleskandarany, M.A., Green, A.R., Soria, D., Kiu Wai Cheng, Hayley Cheung, Craze, Madeleine L., Cheung, Hayley, El-Ansari, R., Nuno D M Coimbra, Craze, Madeleine L, Ellis, I.O., Craze, M.L., Cheng, K.W., Rakha, E., Rokaya El-Ansari, Maria Diez-Rodriguez, Nolan, Christopher C, Coimbra, Nuno D.M., Nolan, Christopher C., Mohammed A Aleskandarany, El-Ansari, Rokaya, Coimbra, Nuno DM, Aleskandarany, Mohammed A., Christopher C Nolan, Rakha, Emad A, Ellis, Ian O., Andrew R Green, Cheng, Kiu Wai, Nolan, C.C., Aleskandarany, Mohammed A   +43 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source