Results 81 to 90 of about 538,260 (299)

Changes of Concentrations of Free Amino Acids in HeLa Cells Induced by Antitumor Agent [PDF]

, 1993
In this report we have investigated that the amino acid is most actively metabolized in the tumor cells damaged by antitumor agents, and discussed imbalanced amino acid procedure to be combined with cancer chemotherapy.
Tomita, Masao, Matsuo, Satoshi, Mine, Yoshikazu, Tagawa, Yutaka, Yasutake, Toru   +4 more
core  

Bovine proteins containing poly-glutamine repeats are often polymorphic and enriched for components of transcriptional regulatory complexes [PDF]

, 2010
peer-reviewedBackground: About forty human diseases are caused by repeat instability mutations. A distinct subset of these diseases is the result of extreme expansions of polymorphic trinucleotide repeats; typically CAG repeats encoding poly-glutamine ...
Herman Raadsma, Raadsma Herman, Lynn David J, Hobbs, Matthew, Whan Vicki, McWilliam, Sean, Lynn, David J, Tellam, Ross L, Barendse William, Tellam Ross L, Ross L Tellam, Vicki Whan, McWilliam Sean, Khatkar Mehar, Lutzow Ylva, David J Lynn, William Barendse, Ylva Lutzow, Whan, Vicki, Khatkar, Mehar, Raadsma, Herman, Tellam, Ross L., Ylva Strandberg Lutzow, Barendse, William, Lutzow, Ylva Strandberg, Sean McWilliam, Lynn, David J., Lutzow, Ylva S, Matthew Hobbs, Hobbs Matthew, Mehar Khatkar   +30 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Metabolomic Approach to Unexplained Syncope

Biomedicines
Background: This study aims to identify a metabolomic signature that facilitates the classification of syncope and the categorization of the unexplained syncope (US) to aid in its management.
Susanna Longo, Ilaria Cicalini, Damiana Pieragostino, Vincenzo De Laurenzi, Jacopo M. Legramante, Rossella Menghini, Stefano Rizza, Massimo Federici   +7 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Efeito da glutamina sobre o turnover do carbono (d13C) de músculos e vísceras de leitões desmamados: glutamina e turnover de carbono tecidual = Effect of glutamine on carbon (d13C) turnover in the muscles and viscera of weaned piglets

Acta Scientiarum: Animal Sciences, 2008
O estudo foi conduzido para verificar a influência da glutamina no turnover do carbono em tecidos de leitões. Nove porcas foram cobertas e receberam dietas compostas predominantemente por grãos de plantas do ciclo fotossintético C4 durante gestação e ...
Fabiana Ribeiro Caldara, Carlos Ducatti, Dirlei Antonio Berto, Juliana Célia Denadai, Evandro Tadeu da Silva, Rodrigo Garófallo Garcia   +5 more
doaj  

Salinity affects indirectly nitrate acquisition associated with glutamine accumulation in cowpea roots

, 2012
The aim of this study was to test the hypothesis that salinity can affect indirectly the nitrate acquisition by a negative modulation triggered by glutamine accumulation.
J. A. G. Silveira, R. M. Aragão, E. N. Silva, S. L. Ferreira-Silva, R. A. Viégas, A. R. B. Melo, M. O. Martins   +6 more
core   +1 more source

Effect of enteral glutamine supplementation for low-birth-weight infants on weight gain patterns and levels of fecal secretory immunoglobulin A [PDF]

, 2018
Aim: Glutamine is needed for optimal cell growth and for the immune system, especially in the enterocytes of gut mucosal immune responses. Low birth weight makes infants susceptible to glutamine depletion because nutrition is limited in the first week of
Martono Tri Utomo, -, Budiono, -, Budiono, Budiono, Mahendra Tri Arif Sampurna, -, Firas Farisi Alkaff, -, Risa Etika, -, Dina Angelika, -, Utomo, Martono Tri, Alkaff, Firas Farisi, Nur Aisiyah Widjaja, -, Irawan, Roedi, Angelika, Dina, Sampurna, Mahendra, Wijaya, Nur Aisiyah, Roedi Irawan, -, Etika, Risa   +15 more
core   +1 more source