Results 111 to 120 of about 760,519 (335)

A randomized trial of glutamine and antioxidants in critically ill patients. [PDF]

, 2013
BACKGROUND: Critically ill patients have considerable oxidative stress. Glutamine and antioxidant supplementation may offer therapeutic benefit, although current data are conflicting.
Heyland, D., Muscedere, J., Wischmeyer, P.E., Cook, D., Jones, G., Albert, M., Elke, G., Berger, M.M., Day, A.G.   +8 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Interplay between glucose and palmitate uptake in breast carcinoma in vitro [PDF]

, 2018
One of the most studied tumor cells lines in vitro is the breast carcinoma MDA-MB-231 cell line. Several studies have proved its glycolytic profile, namely known as the Warburg effect.
Carrillo, Paloma, Martínez-Poveda, Beatriz, Medina, Miguel Ángel, Ocaña, Mª Carmen, Quesada, Ana R.   +4 more
core  

Impaired nutrient signaling and body weight control in a Na⁺ neutral amino acid cotransporter (Slc6a19)-deficient mouse [PDF]

, 2015
Amino acid uptake in the intestine and kidney is mediated by a variety of amino acid transporters. To understand the role of epithelial neutral amino acid uptake in whole body homeostasis, we analyzed mice lacking the apical broad-spectrum neutral (0 ...
Bailey, Charles G., Bröer, Angelika, Bröer, Stefan, Holst, Jeff, Juelich, Torsten, Rasko, John E J, Solomon, Peter S, Tietze, Nadine, Vanslambrouck, Jessica M   +8 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Molecular mechanisms of adaptation of the moderately halophilic bacterium Halobacillis halophilus to its environment [PDF]

, 2013
The capability of osmoadaptation is a prerequisite of organisms that live in an environment with changing salinities. Halobacillus halophilus is a moderately halophilic bacterium that grows between 0.4 and 3 M NaCl by accumulating both chloride and ...
Hänelt, Inga, Müller, Volker
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Supplementation of L-glutamine enhanced mucosal immunity and improved hormonal status of combat-sport athletes

Journal of the International Society of Sports Nutrition
Background Maintaining proper immune function and hormone status is important for athletes to avoid upper respiratory tract infection (URTI) and insufficient recovery, which is detrimental to sport performance and health.
Tung-Lin Lu, Ai-Chi Zheng, Katsuhiko Suzuki, Chi-Cheng Lu, Chung-Yuan Wang, Shih-Hua Fang   +5 more
doaj   +1 more source

GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy [PDF]

, 2021
Anna Mukha, Uğur Kahya, Annett Linge, Oleg Chen, Steffen Löck, Vasyl Lukiyanchuk, Susan Richter, Tiago C. Alves, Mirko Peitzsch, Vladyslav Telychko, Sergej Skvortsov, Giulia Negro, Bertram Aschenbrenner, Ira Skvortsova, Peter Mirtschink, Fabian Lohaus, Tobias Hölscher, Hans Neubauer, Mahdi Rivandi, Vera Labitzky, Tobias Lange, André Franken, Bianca Behrens, Nikolas H. Stoecklein, Marieta Toma, Ulrich Sommer, Sebastian Zschaeck, Maximilian Rehm, Graeme Eisenhofer, Christian Schwager, Amir Abdollahi, Christer Groeben, Leoni A. Kunz‐Schughart, Gustavo Baretton, Michaël Baumann, Mechthild Krause, Claudia Peitzsch, Anna Dubrovska   +37 more
openalex   +1 more source