Results 11 to 20 of about 838,663 (376)
Congenital Glutamine Deficiency with Glutamine Synthetase Mutations [PDF]
New England Journal of Medicine, 2006 Rose, Christopher, Jalan, Rajiv
openaire +4 more sources
Targeting glutamine metabolism as a therapeutic strategy for cancer
Experimental and Molecular Medicine, 2023 Further insights into metabolic reprogramming by cancer cells are needed to determine if targeting glutamine metabolism could be a useful therapeutic approach. Cancer cells rely on the amino acid glutamine for growth and proliferation. Glutamine is a key
J. Jin +3 more
semanticscholar +1 more source
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity
Nature, 2023 Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood^ 1 , 2 . Dendritic cells (DCs), especially type-1 conventional DCs (cDC1s), mediate T cell priming and therapeutic efficacy against ...
Chuansheng Guo +14 more
semanticscholar +1 more source
Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer
Frontiers in Oncology, 2023 Glutamine, the most abundant non-essential amino acid in human blood, is crucial for cancer cell growth and cancer progression. Glutamine mainly functions as a carbon and nitrogen source for biosynthesis, energy metabolism, and redox homeostasis ...
Rui Ni +6 more
doaj +1 more source
Glutamine metabolic reprogramming in hepatocellular carcinoma
Frontiers in Molecular Biosciences, 2023 Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming.
Yanyan Ye +6 more
doaj +1 more source
Nature Immunology, 2023 Unlike metabolic reprogramming that is characteristic of macrophage inflammatory polarization responses to lipopolysaccharide and TLR4 stimulation, the metabolism underlying inflammatory responses to CD40 signaling is not well characterized.
Pu-Ste Liu +11 more
semanticscholar +1 more source
A tracer bolus method for investigating glutamine kinetics in humans. [PDF]
PLoS ONE, 2014 Glutamine transport between tissues is important for the outcome of critically ill patients. Investigation of glutamine kinetics is, therefore, necessary to understand glutamine metabolism in these patients in order to improve future intervention studies.
Maiko Mori +6 more
doaj +1 more source
Enteral Glutamine Modulates Renal Glutamine Utilization [PDF]
The Journal of Nutrition, 1996 Enteral glutamine feeding effect on renal glutamine utilization was assessed from the perspective of gamma glutamyltransferase activity-dependent cellular glutamate modulation of phosphate-dependent glutaminase. After 4d, rats fed an elemental diet supplemented with glutamine exhibited a 2 1 % higher kidney glutamate content and 27% reduction in ...
T, Welbourne, X, Mu, S, Evans
openaire +2 more sources
Cell Communication and Signaling, 2022 Metabolic reprogramming and immune escape play a major role in tumorigenesis. Increasing number of studies have shown that reprogramming of glutamine metabolism is a putative determinant of the anti-tumor immune response in the tumor microenvironment ...
Guofeng Ma +10 more
semanticscholar +1 more source
Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. [PDF]
PLoS Genetics, 2011 Although significant variations in the metabolic profiles exist among different cells, little is understood in terms of genetic regulations of such cell type-specific metabolic phenotypes and nutrient requirements.
Hsiu-Ni Kung +2 more
doaj +1 more source