Results 21 to 30 of about 838,663 (376)

MRI assessment of glutamine uptake correlates with the distribution of glutamine transporters and cancer stem cell markers

Scientific Reports, 2022
Glutamine provides carbon and nitrogen for macromolecular synthesis and participates in adenosine triphosphate (ATP) generation, anabolic metabolism, redox homeostasis, cell signaling, and cancer stem cell (CSC) metabolism.
Yoojeong Seo, Joyeon Kang, Tae Il Kim, Chan Gyu Joo   +3 more
doaj   +1 more source

Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy

Frontiers in Pharmacology, 2022
Glutamine is a conditionally essential amino acid involved in energy production and redox homeostasis. Aging is commonly characterized by energy generation reduction and redox homeostasis dysfunction.
Jiao Zhou, Honghan Chen, Jintao Du, Haoran Tai, Haoran Tai, Xiaojuan Han, Ning Huang, Xiaobo Wang, Hui Gong, Mingyao Yang, Hengyi Xiao   +10 more
doaj   +1 more source

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

eLife, 2021
Tumors frequently exhibit aberrant glycosylation, which can impact cancer progression and therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a major substrate for glycosylation ...
Sydney Campbell, Clementina Mesaros, Luke Izzo, Hayley Affronti, Michael Noji, Bethany E Schaffer, Tiffany Tsang, Kathryn Sun, Sophie Trefely, Salisa Kruijning, John Blenis, Ian A Blair, Kathryn E Wellen   +12 more
doaj   +1 more source

Cellular and molecular outcomes of glutamine supplementation in the brain of succinic semialdehyde dehydrogenase‐deficient mice

JIMD Reports, 2020
Succinic semialdehyde dehydrogenase deficiency (SSADHD) manifests with low levels of glutamine in the brain, suggesting that central glutamine deficiency contributes to pathogenesis.
Madalyn N. Brown, K. Michael Gibson, Michelle A. Schmidt, Dana C. Walters, Erland Arning, Teodoro Bottiglieri, Jean‐Baptiste Roullet   +6 more
doaj   +1 more source

Glutamine reliance in cell metabolism

Experimental and Molecular Medicine, 2020
As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis.
H. Yoo, Ya Chun Yu, Yulseung Sung, J. Han   +3 more
semanticscholar   +1 more source

Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma

Journal of Hematology & Oncology, 2022
Background Besides featured glucose consumption, recent studies reveal that cancer cells might prefer “addicting” specific energy substrates from the tumor microenvironment (TME); however, the underlying mechanisms remain unclear.
Tongyan Liu, Chencheng Han, Panqi Fang, Zhifei Ma, Xiaoxiao Wang, Hao Chen, Siwei Wang, Fanchen Meng, Cheng Wang, E. Zhang, Guozhang Dong, Hongyu Zhu, Wenda Yin, Jie Wang, Xianglin Zuo, M. Qiu, Jinke Wang, Xu Qian, Hongbing Shen, Lin Xu, Zhibin Hu, R. Yin   +21 more
semanticscholar   +1 more source

Targeting glutamine metabolism enhances tumor specific immunity by modulating suppressive myeloid cells.

Journal of Clinical Investigation, 2020
Myeloid cells comprise a major component of the tumor-microenvironment (TME) promoting tumor growth and immune evasion. By employing a novel small molecule inhibitor of glutamine metabolism, not only were we able to inhibit tumor growth, but we markedly ...
M. Oh, Im-Hong Sun, Liang Zhao, R. Leone, Im-Meng Sun, Wei Xu, S. Collins, A. Tam, R. Blosser, Chirag H. Patel, J. Englert, Matthew L. Arwood, Jiayu Wen, Y. Chan-Li, L. Tenora, P. Majer, R. Rais, B. Slusher, M. Horton, J. Powell   +19 more
semanticscholar   +1 more source

GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy

bioRxiv, 2021
Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress and DNA damage in tumor cells.
A. Mukha, U. Kahya, A. Linge, O. Chen, S. Löck, V. Lukiyanchuk, S. Richter, T. C. Alves, M. Peitzsch, V. Telychko, S. Skvortsov, G. Negro, B. Aschenbrenner, I. Skvortsova, P. Mirtschink, F. Lohaus, T. Hölscher, H. Neubauer, M. Rivandi, V. Labitzky, T. Lange, A. Franken, B. Behrens, N. Stoecklein, M. Toma, U. Sommer, S. Zschaeck, M. Rehm, G. Eisenhofer, C. Schwager, A. Abdollahi, C. Groeben, L. Kunz-Schughart, G. Baretton, M. Baumann, M. Krause, C. Peitzsch, A. Dubrovska   +37 more
semanticscholar   +1 more source

Selective glutamine metabolism inhibition in tumor cells improves anti-tumor T lymphocyte activity in triple-negative breast cancer.

Journal of Clinical Investigation, 2020
Rapidly proliferating tumor and immune cells need metabolic programs that support energy and biomass production. The amino acid glutamine is consumed by effector T cells and glutamine-addicted triple-negative breast cancer (TNBC) cells, suggesting that a
Deanna N. Edwards, Verra M. Ngwa, Ariel L. Raybuck, Shan Wang, Y. Hwang, Laura C. Kim, Sung Hoon Cho, Yeeun Paik, Qingfei Wang, Siyuan Zhang, H. C. Manning, J. Rathmell, Rebecca S. Cook, Mark R. Boothby, Jin Chen   +14 more
semanticscholar   +1 more source

Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap

Cancers, 2022
Simple Summary Dysregulated glutamine metabolism is one of the metabolic features evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for energy generation as well as the synthesis of other molecules that are critical ...
A. Halama, K. Suhre
semanticscholar   +1 more source