Results 51 to 60 of about 838,663 (376)

Effect of glutamine supplementation and replacement of tris-egg yolk based extender with defatted cow milk on spermatozoa quality after equilibration and thawing [PDF]

Veterinary World, 2015
Aim: The present study was designed to evaluate the effect of supplementation of glutamine and replacement of Tris-egg yolk (TE) based buffer with defatted cow milk on the spermatozoa quality after equilibration and thawing. Materials and Methods: Semen
Vasundhara Dawra, Brijesh Yadav , Sarvajeet Yadav   +2 more
doaj   +1 more source

The Distinctive Regulation of Cyanobacterial Glutamine Synthetase [PDF]

, 2018
Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria,
Bolay, Paul, Florencio Bellido, Francisco Javier, Klähn, Stephan, Muro Pastor, María Isabel   +3 more
core   +1 more source

Metabolic Analysis of DFO-Resistant Huh7 Cells and Identification of Targets for Combination Therapy

Metabolites, 2023
Hepatocellular carcinoma (HCC) is one of the most refractory cancers with a high rate of recurrence. Iron is an essential trace element, and iron chelation has garnered attention as a novel therapeutic strategy for cancer.
Koichi Fujisawa, Toshihiko Matsumoto, Naoki Yamamoto, Takahiro Yamasaki, Taro Takami   +4 more
doaj   +1 more source

Macrophage-derived glutamine boosts satellite cells and muscle regeneration

Nature, 2020
Muscle regeneration is sustained by infiltrating macrophages and the consequent activation of satellite cells 1 – 4 . Macrophages and satellite cells communicate in different ways 1 – 5 , but their metabolic interplay has not been investigated.
Min Shang, Federica Cappellesso, Ricardo Amorim, J. Serneels, Federico Virga, G. Eelen, S. Carobbio, M. Y. Rincon, P. Maechler, Katrien de Bock, Ping-Chih Ho, M. Sandri, B. Ghesquière, P. Carmeliet, Mario Di Matteo, E. Berardi, M. Mazzone   +16 more
semanticscholar   +1 more source

DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation

Advancement of science, 2021
Extracellular glutamine represents an important energy source for many cancer cells and its metabolism is intimately involved in maintaining redox homeostasis.
Ming Li, R. Thorne, Ronghua Shi, Xu Dong Zhang, Jingmin Li, Jingtong Li, Qingyuan Zhang, Mian Wu, Lianxin Liu   +8 more
semanticscholar   +1 more source

A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle

Journal of experimental & clinical cancer research : CR
Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated glutamine metabolism has been implicated in cancer development and immune responses, supported by ...
Bolin Wang, J. Pei, Shengnan Xu, Jie Liu, Jinming Yu   +4 more
semanticscholar   +1 more source

Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway

Nature, 2013
Cancer cells have metabolic dependencies that distinguish them from their normal counterparts. Among these dependencies is an increased use of the amino acid glutamine to fuel anabolic processes.
J. Son, C. Lyssiotis, H. Ying, Xiaoxu Wang, S. Hua, M. Ligorio, R. Perera, C. Ferrone, Edouard Mullarky, Ng Shyh‐Chang, Ya'an Kang, J. Fleming, N. Bardeesy, J. Asara, M. Haigis, R. DePinho, L. Cantley, Alec C. Kimmelman   +17 more
semanticscholar   +1 more source

LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation

Science Advances, 2021
When glutamine is limiting, lncRNA GIRGL inhibits glutaminase activity through phase separation to enable cancer cell survival. Glutamine constitutes an essential source of both carbon and nitrogen for numerous biosynthetic processes.
Ruijie Wang, Leixi Cao, R. Thorne, Xu Dong Zhang, Jinming Li, Feng-min Shao, Lirong Zhang, Mian Wu   +7 more
semanticscholar   +1 more source

MoGLN2 Is Important for Vegetative Growth, Conidiogenesis, Maintenance of Cell Wall Integrity and Pathogenesis of Magnaporthe oryzae

Journal of Fungi, 2021
Glutamine is a non-essential amino acid that acts as a principal source of nitrogen and nucleic acid biosynthesis in living organisms. In Saccharomyces cerevisiae, glutamine synthetase catalyzes the synthesis of glutamine.
Osakina Aron, Min Wang, Lianyu Lin, Wajjiha Batool, Birong Lin, Ammarah Shabbir, Zonghua Wang, Wei Tang   +7 more
doaj   +1 more source

Reduced glutamine synthetase activity alters the fecundity of female Bactrocera dorsalis (Hendel) [PDF]

, 2019
Glutamine synthetase (GS) is a key enzyme in glutamine synthesis and is associated with multiple physiological processes in insects, such as embryonic development, heat shock response, and fecundity regulation.
Smagghe, Guy, Wang, Jin-Jun, Wei, Dong, Zhang, Meng-Yi, Zhang, Su-Yun, Zhang, Ying-Xin   +5 more
core   +2 more sources