Results 71 to 80 of about 838,663 (376)
Glutamine metabolism in the proliferation of GS-expression pituitary tumor cells
Endocrine Connections, 2020 Objective: Many cancer cells cannot survive without exogenous glutamine (Gln); however, cancer cells expressing glutamine synthetase (GS) do not have this restriction.
Jintao Hu +6 more
doaj +1 more source
Medical Nutrition Therapy in Short Bowel Syndrome and Food Interventions in Intestinal Adaptation
Anadolu Hemşirelik ve Sağlık Bilimleri Dergisi, 2021 The 'normal' length of the small intestine ranges from 320 to 800 cm. short bowel syndrome is defined as the small bowel length less than 200 cm. Short bowel syndrome is a clinical manifestation that occurs mainly after anatomical and / or functional ...
Ebru KOPTAGEL, Hülya KAMARLI ALTUN
doaj +1 more source
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer
Journal of Experimental Medicine, 2020 Pancreatic ductal adenocarcinoma (PDAC) cells rely heavily on glutamine metabolism. Recouvreux et al. demonstrate that nutrient stress caused by glutamine deprivation drives epithelial-mesenchymal transition (EMT) and aggressive behaviors in PDAC cells ...
M. V. Recouvreux +8 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Frontiers in Oncology, 2021 Tumor cells develop a series of metabolic reprogramming mechanisms to meet the metabolic needs for tumor progression. As metabolic hubs in cells, mitochondria play a significant role in this process, including energy production, biosynthesis, and redox ...
Xianglai Ye +33 more
doaj +1 more source
Effect of the nitrogen source on glutamine and alanine biosynthesis in Neurospora crassa. An in vivo 15N nuclear magnetic resonance study [PDF]
, 1982 The influences of different nitrogen sources on the relative rates of biosynthesis of glutamine and alanine have been studied by 15N nuclear magnetic resonance spectroscopy of intact Neurospora crassa mycelia suspensions.
Kanamori, Keiko +3 more
core
Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]
, 2017 Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash +5 more
core +1 more source
eLife, 2020 The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found that human liver cancer was dependent on extracellular glutamine.
Haojie Jin +13 more
semanticscholar +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Patologìâ, 2012 Adult rabbits with experimental glaucoma were used in this study. We studied glutamate and glutamine levels and glutamine synthetase, glutamate oxidase and glutaminase activity in the eye tissue during glaucoma process.
V. M. Serdyuk
doaj +1 more source