Results 91 to 100 of about 12,387 (173)

GLUTATHIONE AND GLUTAREDOXIN IN ROSCOVITINE-MEDIATED INHIBITION OF BREAST CANCER CELL PROLIFERATION

, 2017
Background: Breast tumors are number one cause of cancer morbidity and mortality among women around the world, and Russia is not an exception. Many proteins that control proliferation of immortalized cells are redox-regulated, which is essential for ...
E. V. Rudikov, E. A. Stepovaya, O. L. Nosareva, E. V. Shakhristova, V. V. Novitsky   +4 more
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Cardiac‐specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure

Physiological Reports, 2019
Growing evidence suggests that redox‐sensitive proteins including glutaredoxins (Grxs) can protect cardiac muscle cells from oxidative stress‐induced damage. Mammalian Grx3 has been shown to be critical in regulating cellular redox states.
Jimmonique Donelson, Qiongling Wang, Tanner O. Monroe, Xiqian Jiang, Jianjie Zhou, Han Yu, Qianxing Mo, Qin Sun, Juan C. Marini, Xinquan Wang, Paul A. Nakata, Kendal D. Hirschi, Jin Wang, George G. Rodney, Xander H.T. Wehrens, Ninghui Cheng   +15 more
doaj   +1 more source

CRISPR-Cas9 Mediated Deletion of Glutaredoxin in Lung Epithelial-like Cancer Cells

, 2021
UndergraduateIdiopathic pulmonary fibrosis is a deadly respiratory disease accompanied by changes in the redox environment of the lung. Dr. Janssen-Heininger’s lab has shown reversal of lung fibrosis in mice by administering glutaredoxin protein.
D'Amico, Alexander
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Structural and dynamic analysis of human glutaredoxin 3

Human glutaredoxin (Grx3) is an essential protein associated with biological functions including embryonic development and immune response, and is involved in human disease such as lung, colon cancer and cardiovascular disorder.
Andrésen, Cecilia,, Sunnerhagen, Maria,, Lundström, Patrik,   +2 more
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Deletion of glutaredoxin promotes oxidative tolerance and intracellular infection in Listeria monocytogenes

, 2019
Thiol-disulfide glutaredoxin systems of bacterial cytoplasm favor reducing conditions for the correct disulfide bonding of functional proteins, and therefore were employed by bacteria to defend against oxidative stress.
Jing Sun (141206), Xian Zhang (191440), Li Gan (283942), Yue Han (560788), Zhongwei Chen (309700), Chunyan Shao (7702442), Yang Yang (45629), Houhui Song (201293), Yingshan Zhou (1896223), Yongchun Yang (432280), Yi Hang (7702436), Chang Cai (3276789), Quanjiang Song (7702439), Changyong Cheng (1624090), Xiaodu Wang (7702445)   +14 more
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Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1

, 2013
Embryonic development depends on complex and precisely orchestrated signaling pathways including specific reduction/oxidation cascades. Oxidoreductases of the thioredoxin family are key players conveying redox signals through reversible posttranslational
Dahl Ejby Jensen, Lasse,, Montano, Sergio J,, Dreij, Kristian,, Poschmann, Gereon,, Uhlen, Per,, Brautigam, Lars,, Prozorovski, Timour,, Bannenberg, Sarah,, Lepka, Klaudia,, Holmgren, Arne,, Nystrom, Staffan,, Stuehler, Kai,, Aktas, Orhan,, Cao, Yihai,, Berndt, Carsten,, Bannenberg, S, Montano, SJ, Dreij, K,, Prozorovski, T, Jensen, LDE, Aktas, O, Nystrom, S,, Poschmann, G, Lepka, K, Brautigam, L   +24 more
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Glutaredoxin and glutathione play a role in regulating the activity of the copper transporting ATPases, ATP7A and ATP7B

, 2007
Glutaredoxin and glutathione play a role in regulating the activity of the copper transporting ATPases, ATP7A and ...
M Cater (13694599), Sharon La Fontaine (13094244), Chris Lim (13064580), William Singleton (13051497), Julian Mercer (13076475), B X Ke (13283859)   +5 more
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NMR structure of oxidized glutaredoxin 3 from Escherichia coli

, 2000
A high precision NMR structure of oxidized glutaredoxin 3 [C65Y] from Escherichia coli has been determined. The conformation of the active site including the disulphide bridge is highly similar to those in glutaredoxins from pig liver and T4 phage.
Berndt, Kurt D,, Otting, G, Holmgren, A, Nordstrand, K, Sandstrom, A, Aslund, F   +5 more
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Vertebrate-specific glutaredoxin is essential for brain development

, 2011
Cellular functions and survival are dependent on a tightly controlled redox potential. Currently, an increasing amount of data supports the concept of local changes in the redox environment and specific redox signaling events controlling cell function ...
Manuela Gellert, José Rodrigo Godoy, Timour Prozorovski, Giselbert Hauptmann, Arne Holmgren, Lars Bräutigam, Lena Dorothee Schütte, Carsten Berndt, Christopher Horst Lillig, Holmgren, A,, Gellert, M, Hauptmann, G, Schuette, LD, Godoy, JR, Berndt, C,, Prozorovski, T, Brautigam, L, Lillig, CH   +17 more
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[[alternative]]Total synthesis and biological evaluation of glutathione disulfide analogue

, 2010
[[abstract]]Glutaredoxin為專門且有效地對protein-SSG進行去麩胺基硫反應（deglutathionylation）的催化蛋白質，此外，glutaredoxin也催化進行diglutathionylated HIV-1 protease的去麩胺基硫反應，使原本無活性的HIV-1 protease轉換成超活性狀態（superactive form）；諸多例子指出glutaredoxin幫助恢復了麩胺基硫化蛋白質（S-glutathionylated proteins ...
[[author]]田鎧豪, [[author]]Kai-Hau Tian, 田鎧豪, Kai-Hau Tian   +3 more
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