Results 81 to 90 of about 12,387 (173)

Identifying Ortholog Selective Fragment Molecules for Bacterial Glutaredoxins by NMR and Affinity Enhancement by Modification with an Acrylamide Warhead

Molecules, 2019
Illustrated here is the development of a new class of antibiotic lead molecules targeted at Pseudomonas aeruginosa glutaredoxin (PaGRX). This lead was produced to (a) circumvent efflux-mediated resistance mechanisms via covalent inhibition while (b ...
Ram B. Khattri, Daniel L. Morris, Stephanie M. Bilinovich, Erendra Manandhar, Kahlilah R. Napper, Jacob W. Sweet, David A. Modarelli, Thomas C. Leeper   +7 more
doaj   +1 more source

Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia

, 2017
Demyelinated brain lesions, a hallmark of autoimmune neuroinflammatory diseases like multiple sclerosis, result from oligodendroglial cell damage. Activated microglia are considered a major source of nitric oxide and subsequent peroxynitrite-mediated ...
Hildebrandt, T., Arne Holmgren, Lawrence Steinman, Klaudia Lepka, Natalia Rios, Thomas Hildebrandt, Volbracht, K., Berndt, C., Reiner Schneider, Lillig, C., Steinman, L., Ingwersen, J., Rafael Radi, Hartung, H., Orhan Aktas, Katrin Volbracht, Eckhard Bill, Schneider, R., Lepka, K., Holmgren, A., Bill, E., Prozorovski, T., Jack van Horssen, Carsten Berndt, Rios, N., van Horssen, J., Christopher Horst Lillig, Aktas, O., Timur Prozorovski, Jens Ingwersen, Hans-Peter Hartung, Radi, R., Prozorovski, T, Volbracht, K, Schneider, R, van, Horssen J, Rios, N, Hildebrandt, T, Bill, E, Lepka, K, Ingwersen, J, Lillig, CH   +41 more
core   +1 more source

RNA-Seq Profiling Shows Divergent Gene Expression Patterns in Arabidopsis Grown under Different Densities

Frontiers in Plant Science, 2017
Plants growing under high-density (HD) conditions experience increased competition for water, nutrients, and light, possibly leading to changes in size, biomass, morphology, and productivity.
Di Guo, Di Guo, Xiaoming Song, Xiaoming Song, Min Yuan, Min Yuan, Zhenyi Wang, Zhenyi Wang, Weina Ge, Weina Ge, Li Wang, Li Wang, Jinpeng Wang, Jinpeng Wang, Xiyin Wang, Xiyin Wang   +15 more
doaj   +1 more source

Biochemical and biophysical characterization of a mycoredoxin protein glutaredoxin A1 from Corynebacterium pseudotuberculosis

, 2018
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Processo FAPESP: 2009/53989-4Processo FAPESP: 2015/13765 ...
Monika A. Coronado, Raghuvir K. Arni, Raphael J. Eberle, Eberle, Raphael J. [UNESP], Tasic, Ljubica, de Moraes, Fabio R., Arni, Raghuvir K., Fabio R. de Moraes, Kawai, Liege A. [UNESP], Arni, Raghuvir K. [UNESP], Eberle, Raphael J., Kawai, Liege A., Coronado, Monika A. [UNESP], Liege A. Kawai, Coronado, Monika A., Ljubica Tasic, de Moraes, Fabio R. [UNESP]   +16 more
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Overexpression of rice glutaredoxin OsGrx_C7 and OsGrx_C2.1 reduces intracellular arsenic accumulation and increases tolerance in Arabidopsis thaliana

Frontiers in Plant Science, 2016
Glutaredoxins (Grxs) are a family of small multifunctional proteins involved in various cellular functions, including redox regulation and protection under oxidative stress.
Pankaj Kumar Verma, Shikha eVerma, Veena ePande, Shekhar eMallick, Rudra Deo eTripathi, Om Parkash eDhankher, Debasis eChakrabarty   +6 more
doaj   +1 more source

Cytosolic Isocitrate Dehydrogenase from Arabidopsis thaliana Is Regulated by Glutathionylation

Antioxidants, 2019
NADP-dependent (Nicotinamide Adénine Dinucléotide Phosphate-dependent) isocitrate dehydrogenases (NADP-ICDH) are metabolic enzymes involved in 2-oxoglutarate biosynthesis, but they also supply cells with NADPH. Different NADP-ICDH genes are
Adnan Khan Niazi, Laetitia Bariat, Christophe Riondet, Christine Carapito, Amna Mhamdi, Graham Noctor, Jean-Philippe Reichheld   +6 more
doaj   +1 more source

Soybean Glutaredoxin Gene Responds to Aluminum Toxicity in Soil II [PDF]

, 2002
Oxidizing agents are a normal product of aerobic metabolism and may also be encountered from environmental sources. Aluminum is one proposed source of environmental oxidative stress in plants, and is a major component of soils and an inhibitor of plant ...
Thomas-Bostic, Kisha D.
core  

Glutaredoxin catalysis requires two distinct glutathione interaction sites

, 2017
Glutaredoxins are key players in cellular redox homoeostasis and exert a variety of essential functions ranging from glutathione-dependent catalysis to iron metabolism.
Patricia Begas, Linda Liedgens, Andreas J. Meyer, Anna Moseler, Marcel Deponte   +4 more
core   +1 more source

Engineering functional artificial hybrid proteins between poplar peroxiredoxin II and glutaredoxin or thioredoxin

, 2006
International audienceThe existence of natural peroxiredoxin–glutaredoxin hybrid enzymes in several bacteria is in line with previous findings indicating that poplar peroxiredoxin II can use glutaredoxin as an electron donor.
Gans, Pierre, Rouhier, Nicolas,, Wingsle, Gunnar, Jacquot, Jean-Pierre, Rouhier, Nicolas, Gama, Filipe, Gelhaye, Éric, Rouhier, N, Gama, F, Jacquot, J-P, Swedish University of Agricultural Sciences., Wingsle, Gunnar,, Gelhaye, E, Gans, P   +13 more
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Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: implications in excitotoxicity

, 2007
Oxidative stress, excitotoxicity and mitochondrial dysfunction play synergistic roles in neurodegeneration. Maintenance of thiol homeostasis is important for normal mitochondrial function and dysregulation of protein thiol homeostasis by oxidative stress
Kenchappa, Rajappa S., Diwakar, Latha, Annepu, Jayasree, Ravindranath, Vijayalakshmi   +3 more
core   +1 more source