Results 71 to 80 of about 12,387 (173)

Non-reciprocal regulation of the redox state of the glutathione-glutaredoxin and thioredoxin systems

, 2003
Our studies in yeast show that there is an essential requirement for either an active thioredoxin or an active glutathione (GSH)-glutaredoxin system for cell viability.
Eleanor W Trotter, Grant, Chris M., Chris M Grant, Trotter, Eleanor W.   +3 more
core   +1 more source

Role of GSH and Iron-Sulfur Glutaredoxins in Iron Metabolism—Review

Molecules, 2020
Glutathione (GSH) was initially identified and characterized for its redox properties and later for its contributions to detoxification reactions. Over the past decade, however, the essential contributions of glutathione to cellular iron metabolism have ...
Trnka Daniel, Hossain Md Faruq, Jordt Laura Magdalena, Gellert Manuela, Lillig Christopher Horst   +4 more
doaj   +1 more source

A novel CsRNF‐CsHSF24‐CsF3′5′H2 module regulates epigallocatechin gallate biosynthesis in Camellia sinensis

The Plant Journal, Volume 128, Issue 1, October 2026.
Significance Statement While the biosynthetic pathway of tea catechins is well established, how post‐translational modifications govern this process has remained elusive. This study uncovers a regulatory module in which the E3 ubiquitin ligase CsRNF targets the transcription factor CsHSF24 for degradation, thereby controlling expression of the key ...
Xinzhuan Yao, Hufang Chen, Haili An, Yilan Hu, Tong Li, Qi Zhao, Tengxian He, Chao Luo, Xiaofang Zeng, Litang Lu   +9 more
wiley   +1 more source

Folding mechanism of Glutaredoxin 2 [PDF]

, 2008
Equilibrium unfolding, single- and double-jump kinetic studies were conducted to determine the unfolding and refolding pathway of glutaredoxin 2. Structural changes for wild-type glutaredoxin 2 were monitored by far-ultraviolet circular dichroism and ...
Gildenhuys, Samantha
core  

Identification of glutaredoxin 1 and glutaredoxin 2 genes from Venerupis philippinarum and their responses to benzo[a]pyrene and bacterial challenge

, 2012
Glutaredoxin (abbreviated as Grx) is an important ubiquitous disulfide reductase, which can protect organisms against oxidative stresses. In the present study, a monothiol glutaredoxin gene (named as VpGrx1) and a dithiol glutaredoxin gene (named as ...
Wang, Chunlin, Yuan, Zeyi, Zhang, Zhendong, Mu, Changkao, Wang, Qing   +4 more
core  

Arabidopsis Glutaredoxin S17 Contributes to Vegetative Growth, Mineral Accumulation, and Redox Balance during Iron Deficiency

Frontiers in Plant Science, 2017
Iron (Fe) is an essential mineral nutrient and a metal cofactor required for many proteins and enzymes involved in the processes of DNA synthesis, respiration, and photosynthesis.
Han Yu, Jian Yang, Yafei Shi, Jimmonique Donelson, Sean M. Thompson, Stuart Sprague, Tony Roshan, Da-Li Wang, Jianzhong Liu, Sunghun Park, Paul A. Nakata, Erin L. Connolly, Kendal D. Hirschi, Kendal D. Hirschi, Michael A. Grusak, Michael A. Grusak, Ninghui Cheng   +16 more
doaj   +1 more source

Iron‐Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol‐Related Lipid Metabolic Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Alcohol metabolism induces structural instability of iron‐sulfur clusters through ROS‐mediated oxidative damage and direct covalent modification of acetaldehyde. The iron‐sulfur cluster deficiency drives metabolic reprogramming by inactivating aconitase, accumulating succinate, and impairing tRNA thiolation, thereby promoting hepatic steatosis ...
Li Xu, Zhenyang Xu, Chenli Su, Yanqian Zhao, Linjing Qiang, Xiayong Jing, Yuxiang Sun   +6 more
wiley   +1 more source

Nrf2–Keap1 Axis Modulation by Phytofabricated Metal Oxide Nanoparticles in Mesenchymal Stem Cell Lineage Bias

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Phytofabricated metal oxide nanoparticles may activate the Nrf2–Keap1 axis through a dual‐stimulus mechanism, coupling nanoparticle‐derived ROS with phytochemical‐mediated Keap1 modification, steering mesenchymal stem cells toward osteogenic commitment — a mechanistic framework this review consolidates from current evidence.
Muhammad Irfan, Muhammad Taha, Syed Muhammad Faizan Asghar, Muhammad Raza   +3 more
wiley   +1 more source

Purification from Placenta, Amino Acid Sequence, Structure Comparisons and cDNA Cloning of Human Glutaredoxin

, 1995
Glutaredoxin is generally a glutathione-dependent hydrogen donor for ribonucleotide reductase and also catalyses general glutathione (GSH)-disulfide-oxidoreduction reactions in the presence of NADPH and glutathione reductase.
Bárcena, J. A.,, Arne Holmgren, C. Alicia Padilla, Spyrou, Giannis,, Emilia Martínez‐Galisteo, PADILLA, CA, HOLMGREN, A, SPYROU, G, J. Antonio Bárcena, BARCENA, JA, Martínez-Galisteo, E.,, Holmgren, A.,, Giannis Spyrou, Padilla, C. A.,, MARTINEZGALISTEO, E   +14 more
core   +1 more source

Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease

MedComm, Volume 7, Issue 9, September 2026.
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi, Dongping Yao, Chanjuan Dong, Xiao Tu, Guojian Liao, Mengfei Long, Yongmei Xie   +6 more
wiley   +1 more source