Results 51 to 60 of about 11,635 (216)
The Journal of Physiology, EarlyView.Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu +7 more
wiley +1 more source
Frontiers in Chemistry, 2022 Growing evidence links oxidative stress to the development of a cataract and other diseases of the eye. Treatments for lens-derived diseases are still elusive outside of the standard surgical interventions, which still carry risks today.
Jinmin Zhang +5 more
doaj +1 more source
Special Delivery: Distributing Iron in the Cytosol of Mammalian cells
Frontiers in Pharmacology, 2014 Eukaryotic cells contain hundreds of proteins that require iron cofactors for activity. These iron enzymes are located in essentially every subcellular compartment; thus, iron cofactors must travel to every compartment in the cell.
Caroline C Philpott, Moon-Suhn eRyu
doaj +1 more source
Frontiers in Marine Science, 2022 Glutaredoxins (Grxs) are glutathione-dependent oxidoreductases that belong to the thioredoxin (Trx) superfamily and are an essential part of the redox system in living organisms.
Rui Fan +12 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma +12 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 7, Page 4577-4598, July 2026.ABSTRACT Cold stress threatens wheat productivity, particularly in regions with extreme climatic conditions. To elucidate the molecular mechanisms underlying wheat's response to cold stress, we performed a multiomics analysis integrating lipidomics, transcriptomics, proteomics and metabolomics.
Sofora Jan +15 more
wiley +1 more source
Vaccinia VirusG4LGene Encodes a Second Glutaredoxin
, 1996 Vaccinia virus (VV) was previously shown to encode a functional glutaredoxin, the product of theo2lgene, which is synthesized late in infection, after the onset of DNA replication.
Koonin, Eugene K. +2 more
core +1 more source
Frontiers in Microbiology, 2023 The oxidizability of cysteine residues is exploited in redox chemistry and as a source of stabilizing disulfide bonds, but it also raises the possibility that these side chains will be oxidized when they should not be.
Stefanie S. Eben, James A. Imlay
doaj +1 more source
Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting
MedComm – Future Medicine, Volume 5, Issue 2, June 2026.Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi +2 more
wiley +1 more source
Function and Regulation of Chloroplast Peroxiredoxin IIE
Antioxidants, 2021 Peroxiredoxins (PRX) are thiol peroxidases that are highly conserved throughout all biological kingdoms. Increasing evidence suggests that their high reactivity toward peroxides has a function not only in antioxidant defense but in particular in redox ...
Anna Dreyer +6 more
doaj +1 more source