Results 91 to 100 of about 135,439,936 (222)

Embryonal degreening and seed longevity require plastid LEA proteins

New Phytologist, EarlyView.
Working model of how plastidial LEA proteins aid the remodelling of photosynthetic structures during degreening of Arabidopsis seed embryos. LEA42 and LEA48 support thylakoid proteostasis and membrane remodelling in embryonal cells during late seed maturation by maintaining a local physicochemical environment compatible with protein turnover and ...
Dennis Brandt, Ana Carolina Vilchez, Jürgen Eirich, Paulina Heinkow, Lea Hembach, Ke Zheng, Pedro Barreto, Jan‐Ole Niemeier, Lando Lebok, Ivo Feussner, Felix Buchert, Alexey Amunts, Kristina Kühn, David Macherel, Till Ischebeck, Michael Melzer, Iris Finkemeier, Markus Schwarzländer   +17 more
wiley   +1 more source

Modulation of thiol-dependent redox system by metal ionsviathioredoxin and glutaredoxin systems

, 2018
Metal and metalloid ions regulate thioredoxin and glutaredoxin system-mediated biological functions by targeting mammalian thioredoxin reductase and mitochondrial glutaredoxin 2&5.
Jing Li, Arne Holmgren, Yanfang Ouyang, Yi Peng, Jun Lu, Holmgren, A,, Ouyang, Y, Li, J, Lu, J, Peng, Y   +9 more
core   +1 more source

Molecular Mapping of Functionalities in the Solution Structure of Reduced Grx4, a Monothiol Glutaredoxin from Escherichia coli [PDF]

, 2005
The ubiquitous glutaredoxin protein family is present in both prokaryotes and eukaryotes, and is closely related to the thioredoxins, which reduce their substrates using a dithiol mechanism as part of the cellular defense against oxidative stress ...
MAMMI, STEFANO, FERNANDES A. P., VLAMIS GARDIKAS A., SUNNERHAGEN M., BELLANDA, MASSIMO, HOLMGREN A., FLADVAD M., Bellanda, M, Holmgren, A,, Sunnerhagen, M, Fernandes, Aristi Potamitou,, Vlamis-Gardikas, A, Mammi, S, Fladvad, Malin,, Holmgren, Arne,, Bellanda, Massimo,, Vlamis-Gardikas, Alexios,, Sunnerhagen, Maria,, Mammi, Stefano,, Fladvad, M, Fernandes, AP   +20 more
core   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Sex-dependent Differences in the Bioenergetics of Liver and Muscle Mitochondria from Mice Containing a Deletion for glutaredoxin-2

Antioxidants, 2019
Our group recently published a study demonstrating that deleting the gene encoding the matrix thiol oxidoreductase, glutaredoxin-2 (GRX2), alters the bioenergetics of mitochondria isolated from male C57BL/6N mice.
Sarah Mallay, Robert Gill, Adrian Young, Ryan J. Mailloux   +3 more
doaj   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, Volume 13, Issue 59, 23 October 2026.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Irreversible Inactivation of Glutaredoxins 1 and 2 by Peroxynitrite

Bulletin of the Korean Chemical Society, 2007
who showedthat rat liver cytosolic fractions lose glutaredoxin activitywhen treated with peroxynitrite. Considering the potentialrole of S-glutathionylation in signaling, inactivation ofglutaredoxins by reactive nitrogen species deserves detailedstudy.We report here that peroxynitrite among the nitric oxidecongeners is a very effective inactivator of ...
openaire   +2 more sources

Folding mechanism of Glutaredoxin 2 [PDF]

, 2008
Equilibrium unfolding, single- and double-jump kinetic studies were conducted to determine the unfolding and refolding pathway of glutaredoxin 2. Structural changes for wild-type glutaredoxin 2 were monitored by far-ultraviolet circular dichroism and ...
Gildenhuys, Samantha
core  

Redox regulation of ischemic limb neovascularization – What we have learned from animal studies

Redox Biology, 2017
Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to ...
Reiko Matsui, Yosuke Watanabe, Colin E. Murdoch   +2 more
doaj   +1 more source

Chemical Diversity and Biological Significance of Sesquiterpene Lactones: From Biosynthesis to Anticancer Mechanisms

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari, Ragini Yadav, Mayank Kashyap, Shreyans K. Jain   +3 more
wiley   +1 more source