Results 171 to 180 of about 202,820 (240)

Genetic and Pharmacological Inhibition of Metabotropic Glutamate Receptor Signalling Extends Lifespan in Drosophila

Aging Cell, Volume 24, Issue 5, May 2025.
We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan, Abigail Otchere, Mihails Laskovs, Irene Papatheodorou, Cathy Slack   +4 more
wiley   +1 more source

Compensation of Mutation in Arabidopsis glutathione transferase (AtGSTU) Genes under Control or Salt Stress Conditions. [PDF]

Int J Mol Sci, 2020
Horváth E, Bela K, Gallé Á, Riyazuddin R, Csomor G, Csenki D, Csiszár J.   +6 more
europepmc   +1 more source

Negative Effect of Gst‐35 on the Health Span of Caenorhabditis elegans Through Lysosomal Dysfunction via the Pmk‐1 and Skr Genes

Aging Cell, EarlyView.
The overexpression of gst‐35, the mammalian orthologous genes GSTA1, GSTA2, and GSTA3, induces lysosomal dysfunction through the genes pmk‐1 and skr in C. elegans. This overexpression not only promotes an in vivo inflammatory response and accumulation of reactive oxygen species but also significantly shortens the nematode lifespan; inhibits its ...
Yehui Gao, Xinyun Zhang, Congmin Wei, Hongru Lin, Mengchen Wu, Botian Ma, Jinyun Jiang, Shan Li, Hongbing Wang   +8 more
wiley   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, EarlyView.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

The Moss Leptodictyum riparium Counteracts Severe Cadmium Stress by Activation of Glutathione Transferase and Phytochelatin Synthase, but Slightly by Phytochelatins. [PDF]

Int J Mol Sci, 2020
Bellini E, Maresca V, Betti C, Castiglione MR, Fontanini D, Capocchi A, Sorce C, Borsò M, Bruno L, Sorbo S, Basile A, Sanità di Toppi L.   +11 more
europepmc   +1 more source

Maternal–fetal transfer and longitudinal trends of antibodies to Chlamydia trachomatis and Mycoplasma genitalium in early childhood

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Maternal IgG antibodies against Chlamydia trachomatis and Mycoplasma genitalium are transferred to the fetus during pregnancy, like other IgG antibodies. Early‐life seroconversion to these pathogens was uncommon. Abstract Introduction Sexually transmitted infections caused by Chlamydia trachomatis and Mycoplasma genitalium can have significant ...
Nea Koskela, Julia Butt, Birgitta E. Michels, Kari Syrjänen, Seija Grenman, Tim Waterboer, Stina Syrjänen, Karolina Louvanto   +7 more
wiley   +1 more source

Early‐onset muscle weakness syndrome (MW) in an Australian Holstein calf

Australian Veterinary Journal, Volume 103, Issue 5, Page 298-303, May 2025.
Early‐onset muscle weakness syndrome (MW) is a recessive genetic disorder known to affect Holstein cattle. This report describes the clinical findings in an Australian Holstein calf diagnosed with MW. The calf initially presented for examination at a dairy farm at 3 days of age, being recumbent since birth but able to stand with assistance.
MG Ciacia, AJ Phipps
wiley   +1 more source

Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance.

Org Biomol Chem, 2021
Schwarz M, Eno RFM, Freitag-Pohl S, Coxon CR, Straker HE, Wortley DJ, Hughes DJ, Mitchell G, Moore J, Cummins I, Onkokesung N, Brazier-Hicks M, Edwards R, Pohl E, Steel PG.   +14 more
europepmc   +1 more source

Expressed sequence tag survey of gene expression in the scab mite Psoroptes ovis--allergens, proteases and free-radical scavengers [PDF]

, 2003
Blaxter, M L, Kenyon, F, Knox, D P, Parkinson, J, Welsh, M, Whitton, C   +5 more
core   +1 more source

Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin, Cristina Lagatolla, Sofia Sindici Forgiarini, Mathias Haag, Sylvia Karin Neef, Manola Comar, Elke Schaeffeler, Barbara Bellich, Matteo Bramuzzo, Giuliana Decorti, Marianna Lucafò, Ute Hofmann, Matthias Schwab, Gabriele Stocco   +13 more
wiley   +1 more source