Results 151 to 160 of about 127,735 (256)

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol, Alparslan Kadir Devrim, Miyase Çinar, Mahmut Sözmen, Fatma Betül Akça   +4 more
wiley   +1 more source

The effect of the combination therapy with chlorophyllin, a glutathione transferase P1-1 inhibitor, and docetaxel on triple-negative breast cancer invasion and metastasis in vivo/in vitro. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Burus A, Ozcan M, Canpinar H, Bozdemir O, Zeybek ND, Bayazit Y.   +5 more
europepmc   +1 more source

Engineering a Pseudo-26-kDa Schistosoma Glutathione Transferase from bovis/haematobium for Structure, Kinetics, and Ligandin Studies. [PDF]

Biomolecules, 2021
Padi N, Akumadu BO, Faerch O, Aloke C, Meyer V, Achilonu I.   +5 more
europepmc   +1 more source

Exposure–Recovery Approach for Hepatic Toxicity Analysis of Pyrethroid Lambda‐Cyhalothrin: Histopathological, Histochemical, and Biochemical Responses in Oreochromis niloticus

Journal of Applied Toxicology, EarlyView.
ABSTRACT Lambda‐cyhalothrin is a synthetic pyrethroid insecticide widely used in agriculture, but its potential to contaminate aquatic ecosystems and exert high toxicity on fish at low concentrations raises ecotoxicological concerns. While standard histopathological and biochemical assessments are common, the novel integration of pigment‐based ...
Carlos Eurico Fernandes, André Luiz do Nascimento Silva, Tiago Venancio da Silva, Karine Nathiele Nogueira Farias, Sabrina Fuzer Gonçalves, Brenda de Oliveira Martins, Maria Eduarda Corona Garcia, Lilian Franco‐Belussi   +7 more
wiley   +1 more source

Mutations Selectively Evolving Peroxidase Activity Among Alternative Catalytic Functions of Human Glutathione Transferase P1-1. [PDF]

Antioxidants (Basel)
Ismail A, Mannervik B.
europepmc   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Association of Glutathione Transferase M1, T1, P1 and A1 Gene Polymorphism and Susceptibility to IgA Vasculitis. [PDF]

Int J Mol Sci
Juras A, Crkvenac Gornik K, Held M, Sestan M, Turudic D, Sapina M, Srsen S, Huljev Frkovic S, Frkovic M, Gagro A, Jelusic M.   +10 more
europepmc   +1 more source

The soluble glutathione transferase superfamily: role of Mu class in triclabendazole sulphoxide challenge in Fasciola hepatica. [PDF]

Parasitol Res, 2021
Stuart RB, Zwaanswijk S, MacKintosh ND, Witikornkul B, Brophy PM, Morphew RM.   +5 more
europepmc   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Genome-wide identification and expression analysis of the glutathione transferase gene family and its response to abiotic stress in rye (Secale cereale). [PDF]

BMC Genomics
Shi H, Wan K, Dou B, Ren Y, Huo L, Zhang C, Yue S, Li Z, Guo H, Dai J.   +9 more
europepmc   +1 more source