Results 171 to 180 of about 148,506 (307)

Conservation of Glutathione Transferase mRNA and Protein Sequences Similar to Human and Horse Alpha Class GST A3-3 across Dog, Goat, and Opossum Species. [PDF]

Biomolecules, 2023
Hubert SM, Samollow PB, Lindström H, Mannervik B, Ing NH.   +4 more
europepmc   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Selenium independent glutathione peroxidase activity associated with cationic forms of glutathione transferase in human heart

, 1986
Glutathione peroxidase activity with both hydrogen peroxide and cumene hydroperoxide was measured in the cytosolic fractions prepared from five human hearts obtained from post-mortem victims.
CACCURI, ANNA MARIA, Lo Bello, M, FEDERICI, GIORGIO, Sacchetta, P, LO BELLO, MARIO, Di Ilio, C, Federici, G, Caccuri, A   +7 more
core  

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Studies on hepatic glutathione transferases from rat and man : 1. A kinetic mechanism for glutathione transferase A from rat liver. 2. Transferase µ, a new form of glutathione transferase in human liver

, 1983
This study of glutathione transferases was undertaken to achieve a better understanding of the catalytic and molecular properties of various isozymes of this group of drug-metabolizing enzymes.The steady-state kinetics of purified glutathione transferase
Warholm, Margareta,
core  

A Key Role in Catalysis and Enzyme Thermostability of a Conserved Helix H5 Motif of Human Glutathione Transferase A1-1. [PDF]

Int J Mol Sci, 2023
Chronopoulou EG, Mutabdzija L, Poudel N, Papageorgiou AC, Labrou NE.   +4 more
europepmc   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Structural and Functional Characterization of Camelus dromedarius Glutathione Transferase M1-1. [PDF]

Life (Basel), 2022
Perperopoulou F, Poudel N, Papageorgiou AC, Ataya FS, Labrou NE.   +4 more
europepmc   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Expression of Glutathione S-transferase-pi (GST-pi)and Metallothionein (MT)in Lung Cancer

, 1997
細胞内解毒酵素であるグルタチオンS一トランスフェラーゼπ(GST一π)やメタロチオネイン(MT)が癌細胞の抗癌剤耐性に関与していることが実験的に示唆されている.本研究では, GST一πとMTの発現を手術肺癌97例で免疫組織染色にて分析し, 化学療法との関係を検討した.GST一πは未治療の非小細胞肺癌56例て86%陽性と小細胞肺癌より有意に発現が高かった ...
岡, 三喜男, 藤野, 了, 坂本, 晃, 井上, 祐一, 木下, 明敏, 福田, 実, 早田, 宏, 福田, 正明, 高谷, 洋, 河野, 茂   +9 more
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