Results 171 to 180 of about 224,471 (305)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Biochemical and Structural Characterization of Chi-Class Glutathione Transferases: A Snapshot on the Glutathione Transferase Encoded by sll0067 Gene in the Cyanobacterium Synechocystis sp. Strain PCC 6803. [PDF]

Biomolecules, 2022
Mocchetti E, Morette L, Mulliert G, Mathiot S, Guillot B, Dehez F, Chauvat F, Cassier-Chauvat C, Brochier-Armanet C, Didierjean C, Hecker A.   +10 more
europepmc   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Identification of glutathione transferase (GST P1) inhibitors via a high-throughput screening assay and implications as alternative treatment options for breast cancers. [PDF]

PLoS One
Pereira SAP, Vesin J, Chambon M, Turcatti G, Saraiva MLMFS, Dyson PJ.   +5 more
europepmc   +1 more source

Characterization of Dog Glutathione Transferase P1-1, an Enzyme Relevant to Veterinary Medicine. [PDF]

Int J Mol Sci, 2021
Ismail A, Lewis E, Sjödin B, Mannervik B.   +3 more
europepmc   +1 more source

Transcriptome-wide identification of differentially expressed genes in Solanum lycopersicon L. In response to an Alfalfa-protein hydrolysate using microarrays [PDF]

, 2017
Ertani, Andrea, Nardi, Serenella, Schiavon, Michela   +2 more
core   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Characterization of FosA13, a novel fosfomycin glutathione transferase identified in a <i>Morganella morganii</i> isolate from poultry. [PDF]

Front Cell Infect Microbiol
Zhang R, Yu Y, Huang L, Chen S, Hu R, Wang X, Huang D, Song C, Lu J, Bao Q, Hu Y, Jiang P, Pan W.   +12 more
europepmc   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

Role of glutathione transferase in phase separation of FUS and TAF15 in neurons. [PDF]

Neural Regen Res
Kim K.
europepmc   +1 more source