Results 181 to 190 of about 223,107 (283)

MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen, Yong‐Hong Yu, Yan‐Hua Du, Lin Xu, Xiang‐Ping Meng   +4 more
wiley   +1 more source

Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules. [PDF]

ACS Med Chem Lett, 2021
Li X, Lü Z, Wang C, Li K, Xu F, Xu P, Niu Y.   +6 more
europepmc   +1 more source

Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK‐3β Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium‐protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (HHD) and explored the underlying mechanism.
Yan‐Jun Yang, Jiu‐Sheng Li
wiley   +1 more source

The effect of the combination therapy with chlorophyllin, a glutathione transferase P1-1 inhibitor, and docetaxel on triple-negative breast cancer invasion and metastasis in vivo/in vitro. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Burus A, Ozcan M, Canpinar H, Bozdemir O, Zeybek ND, Bayazit Y.   +5 more
europepmc   +1 more source

A dual role for glutathione transferase U7 in plant growth and protection from methyl viologen-induced oxidative stress. [PDF]

Plant Physiol, 2021
Ugalde JM, Lamig L, Herrera-Vásquez A, Fuchs P, Homagk M, Kopriva S, Müller-Schüssele SJ, Holuigue L, Meyer AJ.   +8 more
europepmc   +1 more source

Adipose Tissue‐Derived Small Extracellular Vesicles in Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance

Obesity, EarlyView.
ABSTRACT Objective Glucose tolerance (GT) is a major effector for adipose tissue (AT) remodeling in obesity, yet its molecular mechanisms remain incompletely defined. We hypothesized that the biophysical and molecular profiles of AT‐derived small extracellular vesicles (sEVAT) change in response to glucose availability and differ by GT status.
Shalini Mishra, Yixin Su, Ashish Kumar, Sangeeta Singh, Brian S. Finlin, Fang‐Chi Hsu, Jingyun Lee, Cristina M. Furdui, Philip A. Kern, Swapan K. Das, Gagan Deep   +10 more
wiley   +1 more source

Engineering a Pseudo-26-kDa Schistosoma Glutathione Transferase from bovis/haematobium for Structure, Kinetics, and Ligandin Studies. [PDF]

Biomolecules, 2021
Padi N, Akumadu BO, Faerch O, Aloke C, Meyer V, Achilonu I.   +5 more
europepmc   +1 more source

The Curious Case of CysE: Diversity and Distribution of Serine Acetyltransferases in Bacteria

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Serine acetyltransferase (CysE) is a member of the left‐handed β‐helix family of acetyltransferases that catalyze the rate limiting step in de novo cysteine biosynthesis. There are two isoforms of CysE that differ in length, with the shorter isoform lacking approximately 76 amino acids at the N‐terminus of the protein from the serine ...
Keely E. A. Oldham, Adele K. Williamson, Emily K. Grout, Joanna L. Hicks   +3 more
wiley   +1 more source

Mutations Selectively Evolving Peroxidase Activity Among Alternative Catalytic Functions of Human Glutathione Transferase P1-1. [PDF]

Antioxidants (Basel)
Ismail A, Mannervik B.
europepmc   +1 more source

Susceptibility of Phthorimaea absoluta (Meyrick) (Lepidoptera: Gelechiidae) to novel and established insecticides in Brazil: resistance survey, baseline, and implications for management

Pest Management Science, EarlyView.
Baseline susceptibility of Phthorimaea absoluta to novel insecticides isocycloseram and tolfenpyrad was established in Brazil. Diagnostic doses were proposed for early resistance detection. Early tolfenpyrad tolerance and abamectin‐driven cross‐tolerance to isocycloseram via oxidases highlight cross‐resistance risks, emphasizing the need for routine ...
Vitor Quintela, Teófilo P Langa, José VCR Dantas, Marcos de Oliveira, Herbert AA Siqueira   +4 more
wiley   +1 more source