Results 181 to 190 of about 202,820 (240)
Cancer Science, Volume 116, Issue 5, Page 1268-1281, May 2025.The specific role of Glutathione S‐transferase P1 (GSTP1) in pancreatic cancer (PC) has rarely been investigated. In current study, our results suggest that the positive feedback regulation of GSTP1 and wildtype p53 (wtp53) plays a significant role in cell proliferation, drug resistance, cell invasion and metastasis in PC.
Guosen Wang +10 more
wiley +1 more source
Cancer Science, EarlyView.We have demonstrated that prestimulation of human lung cancer cells with TGF‐β enhances resistance to doxorubicin‐induced growth inhibition, depending on Smad3 and Smad4 through induction of ALDH1A1. Knockdown of ALDH1A1 suppressed TGF‐β‐induced resistance to doxorubicin, and exogenous expression of ALDH1A1 in SMAD3‐KO cells restored the drug ...
Takashi Yokoyama +2 more
wiley +1 more source
Cell Proliferation, Volume 58, Issue 4, April 2025.Diagram illustrating the impact of OEM on oocyte‐cumulus communication, showing reduced TZPs, mitochondrial dysfunction, increased oxidative stress, DNA damage, and apoptosis. Melatonin (MLT) treatment improves communication, enhances mitochondrial function, reduces DNA damage, and restores oocyte quality, offering insights into potential therapeutic ...
Lei Ge +11 more
wiley +1 more source
Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals
Cell Proliferation, EarlyView.One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye +6 more
wiley +1 more source
Multi‐Omics Reveal the Metabolic Changes in Cumulus Cells During Aging
Cell Proliferation, EarlyView.Fatty acid β‐oxidation was elevated in cumulus cells from older mice. Tryptophan metabolism in aged cumulus cells was active. Supplementing with 5‐HT could mitigate aging damage in oocytes. ABSTRACT Maternal age has been reported to impair oocyte quality.
Liangyue Shi +6 more
wiley +1 more source
Detoxification of Reactive Carbonyl Species by Glutathione Transferase Tau Isozymes. [PDF]
Front Plant Sci, 2019 Mano J +4 more
europepmc +1 more source
Proteomic associations with fluctuation and long‐term changes in BMI: A 40‐year follow‐up study
Diabetes, Obesity and Metabolism, EarlyView.Abstract Introduction While some studies have explored associations between weight change and blood proteins, most have been intervention‐based, offering limited insight into proteomic associations with long‐term weight gain. It remains unclear whether plasma proteins are related to BMI fluctuation over time.
Alvaro Obeso +6 more
wiley +1 more source
Entomologia Experimentalis et Applicata, EarlyView.We investigated the molecular basis of host switching by the phytophagous West Indian fruit fly (A. obliqua). Third‐instar larvae showed differential gene expression according to host plants: red mombin, mango, and carambola. The main gene categories differentially expressed were digestion, detoxification, and gene regulators.
Sandra M. Velasco‐Cuervo +5 more
wiley +1 more source
Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure. [PDF]
Dis Markers, 2019 Simeunovic D +14 more
europepmc +1 more source