Results 191 to 200 of about 202,820 (240)

Differential gene expression toward species of Aristolochia impairing the performance of the Troidini butterfly Battus polydamas

Entomologia Experimentalis et Applicata, EarlyView.
We studied the response of Battus polydamas (Papilionidae) larvae fed on Aristolochia ringens (containing several diterpenes) and Aristolochia gigantea (containing sesquiterpenes and acyclic monoterpenoids but no diterpenoids or aristolochic acids). We assessed larval performance on fitness components such as survival and differential gene expression ...
Karina L. Silva‐Brandão, Clécio Fernando Klitzke, Marcelo M. Brandão, José Roberto Trigo   +3 more
wiley   +1 more source

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1. [PDF]

Proc Natl Acad Sci U S A, 2019
De Luca A, Parker LJ, Ang WH, Rodolfo C, Gabbarini V, Hancock NC, Palone F, Mazzetti AP, Menin L, Morton CJ, Parker MW, Lo Bello M, Dyson PJ.   +12 more
europepmc   +1 more source

Plasma metabolome reveals altered oxidative stress, inflammation, and amino acid metabolism in dogs with idiopathic epilepsy

Epilepsia, Volume 66, Issue 4, Page 1315-1328, April 2025.
An overview of the study protocol including 88 client‐owned dogs: 39 healthy controls (HC), 22 dogs with mild phenotype (MP) and 27 drug‐resistant (DR) idiopathic epilepsy. UHPLC‐HRMS, ultra‐high‐performance liquid chromatography coupled to hybrid quadrupole‐Orbitrap high resolution mass spectrometry Abstract Objective Idiopathic epilepsy (IE) is the ...
Fien Verdoodt, Sofie F. M. Bhatti, Jenifer Molina, Luc Van Ham, Lynn Vanhaecke, Greet Junius, Lieselot Y. Hemeryck, Myriam Hesta   +7 more
wiley   +1 more source

On the Inhibition Mechanism of Glutathione Transferase P1 by Piperlongumine. Insight From Theory. [PDF]

Front Chem, 2018
Prejanò M, Marino T, Russo N.
europepmc   +1 more source

Molecular mechanisms of hotspot variants in cytoskeletal β‐actin associated with Baraitser–Winter syndrome

The FEBS Journal, EarlyView.
Variants at position R196 in cytoskeletal β‐actin are the most common variants associated with Baraitser–Winter cerebrofrontofacial syndrome and result in craniofacial anomalies and neurodevelopmental disorders, most likely due to neuronal migration defects. This study explores the molecular mechanisms of p.R196 variants using purified proteins.
Johannes N. Greve, Dietmar J. Manstein
wiley   +1 more source

Potency of agarose gel‐supported lipid bilayers for electrophysiologic analysis of channel pores formed by Bacillus thuringiensis insecticidal proteins

The FEBS Journal, EarlyView.
Agarose gel‐supported lipid bilayers constructed at the interface between the lipid solution and the recording solution are useful for measuring channel currents through different types of toxin pores. In this system, the lipid bilayers can be easily reconstructed even after the bilayer is disrupted, and measurements of toxin pores could be repeated ...
Tsubasa Okuda, Tomoya Takeuchi, Mami Asakura, Minako Hirano, Toru Ide, Tohru Hayakawa   +5 more
wiley   +1 more source

Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44

The FEBS Journal, EarlyView.
Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser, Milena Lubisch, Emma Schröder, Luka Ressmann, Marie Nicolaus, Dustin Leusder, Sven Moyzio, Robert Peuss, Antonio Miranda‐Vizuete, Eva Liebau   +9 more
wiley   +1 more source

Obesity‐Induced Metabolic Priming Exacerbates SARS‐CoV‐2 Inflammation

Immunology, EarlyView.
Monocytes primed under obesogenic conditions, such as increased FFA levels (i.e., palmitate) exhibit exacerbated gene expression of inflammatory cytokines. The increased proinflammatory response of palmitate‐primed and SARS‐CoV‐2‐infected monocytes is not dependent on glycolytic metabolism but instead on the entry of FFAs into the mitochondria ...
Gustavo Gastão Davanzo, Bianca Gazieri Castelucci, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Larissa Menezes dos Reis, Isabella Bonilha de Oliveira, José Luís Fachi, João Victor Virgilio‐da‐Silva, Marcelo Rodrigues Berçot, Mariane Font Fernandes, Sarah de Oliveira, Nathalia Vitoria Pereira Araujo, Guilherme Ribeiro, Gisele de Castro, Webster Leonardo Guimarães Costa, Adriana Leandra Santoro, Gabriela Flavia Rodrigues‐Luiz, Helison Rafael P. do Carmo, Ikaro Breder, Marcelo A. Mori, Alessandro S. Farias, Daniel Martins‐de‐Souza, Joseph W. Guarnieri, Douglas C. Wallace, Marco Aurélio Ramirez Vinolo, José Luiz Proença‐Módena, Afshin Beheshti, Andrei C. Sposito, Pedro M. Moraes‐Vieira   +28 more
wiley   +1 more source

Plant viruses convergently target NPR1 with various strategies to suppress salicylic acid‐mediated antiviral immunity

Journal of Integrative Plant Biology, Volume 67, Issue 5, Page 1395-1412, May 2025.
Viral infection triggers monomerization and nuclear translocation of the salicylic acid receptor NONEXPRESSOR OF PATHOGENESIS‐RELATED GENES1 (NPR1) to activate pathogenesis‐related gene expression. Nevertheless, viruses have developed one or more proteins to target NPR1 and impair its functionality through mechanisms such as inducing its degradation ...
Xue Jiang, Yingshuai Yang, Yong Li, Yongzhi Wang, Bernardo Rodamilans, Weiqin Ji, Xiaoxia Wu, Juan Antonio García, Xiaoyun Wu, Xiaofei Cheng   +9 more
wiley   +1 more source

Accumulation of the phytoalexin glyceollin i in soybean nodules infected by a bradyrhizobium-japonicum-nifa mutant [PDF]

, 1991
Fischer, H., Hennecke, H., Parniske, Martin, Werner, Dietrich   +3 more
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