Results 181 to 190 of about 19,474 (199)
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Negative effect of noscapine on human serum albumin glycation
Journal of Pharmaceutical Negative Results, 2012Introduction: Glycation, one of the post-translational modifications of proteins, is a nonenzymatic reaction initiated by the primary addition of sugar to the amino groups of proteins. In the early stage of glycation, the synthesis of intermediates leads to the formation of Amadori compounds.
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Effects of non-enzymatic glycation in human serum albumin. Spectroscopic analysis
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2016Human serum albumin (HSA), transporting protein, is exposed during its life to numerous factors that cause its functions become impaired. One of the basic factors --glycation of HSA--occurs in diabetes and may affect HSA-drug binding. Accumulation of advanced glycation end-products (AGEs) leads to diseases e.g.
A, Szkudlarek +4 more
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Study of Hemoglobin and Human Serum Albumin Glycation with Electrochemical Techniques
Electroanalysis, 2010AbstractHigh concentration glucose in diabetes mellitus may stimulate nonenzymatic glycation of proteins. Hemoglobin (Hb) and human serum albumin (HSA) are among the most sensitive proteins for the modification by glucose. In this paper, we report our study of Hb and HSA modification by glucose using electrochemical methods. Compared with native Hb, it
Jinghua Yang +4 more
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In vitro human serum albumin glycation monitored by Terahertz spectroscopy
Optical and Quantum Electronics, 2015The nonenzymatic attachment of sugars to proteins, namely glycation, is accelerated under diabetic conditions. Monitoring the glycated human serum albumin (HSA) levels gives the short term variation of glucose concentration in diabetic patients blood. Therefore, a significant effort was made to measure glycated HSA, including by spectroscopic methods ...
Maria Mernea +6 more
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Chemiluminescence of Glycated Human Serum Albumin: Comparison with Synthetic Polymer
Collection of Czechoslovak Chemical Communications, 1997The mechanism of protein glycation (nonenzymatic glycosylation) is complicated by existence of a variety of factors which affect both the kinetics and specificity of protein modification. In order to eliminate some of these factors, we have used a synthetic copolymer on the basis of polymethacrylic acid amide. Human serum albumin and the copolymer were
Robert Zoulík +3 more
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Probing the effect of glycation on the pseudo-esterase activity of Human Serum Albumin
International Journal of Biological MacromoleculesHuman Serum Albumin (HSA), a major protein in blood plasma, exhibits pseudo-enzymatic activity such as pseudo-esterase activity. This study explores the impact of glycation on the pseudo-esterase activity of HSA. Glycation, a non-enzymatic reaction between reducing sugars and HSA was induced using glucose, fructose, and ribose.
Sreshtha, Chaki +3 more
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Selection of aptamers for human serum albumin and its glycated form
2016Diabetes prevalence is increasing above and beyond what can be attributed to population growth as reduced physical activity and increased sugar in people's diets is leading to an epidemic that is pushing healthcare systems to breaking point. While therapeutic treatments remain limited for diabetes patients, measurement and management of their glycemic ...
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