ABSTRACT Background Previous exposure to hepatitis B virus (HBV) may influence the risk of developing hepatocellular carcinoma (HCC) and other liver‐related events (LRE), in particular in patients after HCV cure. Previous studies were not conclusive and there are only few large studies on this topic from Europe. Methods We analysed clinical endpoints (≥
Laura Muana Wilhelm +10 more
wiley +1 more source
C-Reactive protein and risk of ESRD: results from the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT) [PDF]
Background: To better understand a potential association of elevated C-reactive protein (CRP) level with progression of chronic kidney disease (CKD), we examined the relationship of CRP level with the development of end-stage renal disease (ESRD) in ...
Burdmann, Emmanuel A. +12 more
core +1 more source
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He +10 more
wiley +1 more source
The ethanolic extract of Eryngium billardierei F. Delaroche restrains protein glycation in human serum albumin: an in vitro study [PDF]
Protein glycation is directly associated with many pathological conditions. This study investigated the potential of Eryngium billardierei extract to inhibit the glycation process in human serum albumin (HSA).
Yavari Sanaz +2 more
doaj +1 more source
Effect of Blood Glucose Concentrations on the Development of Chronic Complications of Diabetes Mellitus [PDF]
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90229/1/j.1875-9114.1998.tb03927.x ...
Montgomery, Patricia A. +1 more
core +1 more source
Unlocking beta cell health: The clinical potential of extracellular vesicles in type 1 diabetes
Extracellular vesicles serve as minimally invasive biomarkers of β‑cell stress and immune dysregulation in T1D. This review highlights the potentials of EVs as a biomarker to improve early detection and disease staging in type 1 diabetes. Abstract Background Type 1 diabetes (T1D) is a lifelong autoimmune disease characterised by progressive immune ...
Nanthini Jayabalan +4 more
wiley +1 more source
Inhibitory Effects of Some Carbohydrates on Nano-Globular Aggregation of both Normal and Glycated Albumin. [PDF]
BACKGROUND: Protein aggregation is one of the important, common and troubling problems in biotechnology, pharmaceutical industries and amyloid-re-lated disorders. METHODS: In the present study, the inhibitory effects of some carbohydrates (alginate, β-
Heli, Hossein. +3 more
core
This study shows that urinary nephrin and related podocyte injury markers are elevated among people living with diabetes in Ghana, particularly those with macroalbuminuria. Nephrin demonstrated discriminatory ability, supporting its role as an exploratory biomarker for diabetic nephropathy rather than a standalone diagnostic tool.
Helen Owusu‐Asante +3 more
wiley +1 more source
Advanced Glycation End Products Acutely Impair Ca2+ Signaling in Bovine Aortic Endothelial Cells [PDF]
Post-translational modification of proteins in diabetes, including formation of advanced glycation end products (AGEs) are believed to contribute to vascular dysfunction and disease.
Alicia J. Jenkins +5 more
core +2 more sources
Effects of Fatty Acids and Glycation on Drug Interactions with Human Serum Albumin
The presence of elevated glucose concentrations in diabetes is a metabolic change that leads to an increase in the amount of non-enzymatic glycation that occurs for serum proteins. One protein that is affected by this process is the main serum protein, human serum albumin (HSA), which is also an important carrier agent for many drugs and fatty acids in
Anguizola, Jeanethe +2 more
openaire +3 more sources

