Results 1 to 10 of about 16,095 (148)

Altered Sphingolipids, Glycerophospholipids, and Lysophospholipids Reflect Disease Status in Idiopathic Steroid-Sensitive Nephrotic Syndrome in Children: A Non-Targeted Metabolomic Study [PDF]

Cells
Idiopathic steroid-sensitive nephrotic syndrome (ISSNS) is the most common glomerular disease in children, yet its molecular mechanisms and lipid-mediated pathophysiology remain poorly understood.
Takahiro Kanai, Hideo Ogiso, Jun Aoyagi, Masanori Kurosaki, Tomomi Maru, Marika Ishii, Kazuya Tanimoto, Mitsuaki Yoshino, Yuri Yamashita, Toshihiro Tajima, Ryozo Nagai, Kenichi Aizawa   +11 more
doaj   +2 more sources

A serum metabolomics study of vascular cognitive impairment patients based on Traditional Chinese medicine syndrome differentiation

Frontiers in Molecular Biosciences, 2023
Objective: Vascular cognitive impairment (VCI) accounts for approximately 50%–70% of all dementia cases and poses a significant burden on existing medical systems.
Li Liu, Yi-fei Qi, Min Wang, Bao-xin Chen, Qing-bing Zhou, Wen-xin Tong, Ying Zhang   +6 more
doaj   +1 more source

Remodeling of the Enterococcal Cell Envelope during Surface Penetration Promotes Intrinsic Resistance to Stress

mBio, 2022
Enterococcus faecalis is a normal commensal of the human gastrointestinal tract (GIT). However, upon disruption of gut homeostasis, this nonmotile bacterium can egress from its natural niche and spread to distal organs.
Yusibeska Ramos, Stephanie Sansone, Sung-Min Hwang, Tito A. Sandoval, Mengmeng Zhu, Guoan Zhang, Juan R. Cubillos-Ruiz, Diana K. Morales   +7 more
doaj   +1 more source

FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins in cells of different lineages

Journal of Lipid Research, 2023
Recent advances in single-cell genomics and transcriptomics technologies have transformed our understanding of cellular heterogeneity in growth, development, ageing, and disease; however, methods for single-cell lipidomics have comparatively lagged ...
Sarah E. Hancock, Eileen Ding, Emma Johansson Beves, Todd Mitchell, Nigel Turner   +4 more
doaj   +1 more source

Characterization of brain‐derived extracellular vesicle lipids in Alzheimer's disease

Journal of Extracellular Vesicles, 2021
Lipid dyshomeostasis is associated with the most common form of dementia, Alzheimer's disease (AD). Substantial progress has been made in identifying positron emission tomography and cerebrospinal fluid biomarkers for AD, but they have limited use as ...
Huaqi Su, Yepy H. Rustam, Colin L. Masters, Enes Makalic, Catriona A. McLean, Andrew F. Hill, Kevin J. Barnham, Gavin E. Reid, Laura J. Vella   +8 more
doaj   +1 more source

Cell Type Variability in the Incorporation of Lipids in the Dengue Virus Virion

Viruses, 2022
A lipid bilayer produced from the host membrane makes up around 20% of the weight of the dengue virus (DENV) virion and is crucial for virus entry. Despite its significance, the virion’s lipid composition is still poorly understood.
Atitaya Hitakarun, Maia Kavanagh Williamson, Nathamon Yimpring, Wannapa Sornjai, Nitwara Wikan, Christopher J. Arthur, Julien Pompon, Andrew D. Davidson, Duncan R. Smith   +8 more
doaj   +1 more source

Roles of polyunsaturated fatty acids, from mediators to membranes

Journal of Lipid Research, 2020
PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding their precise roles and modes of action remains challenging. PUFAs are precursors for a plethora of signaling lipids, for which knowledge about synthetic pathways and ...
Takeshi Harayama, Takao Shimizu
doaj   +1 more source

Arachidonic acid mobilization among phospholipids in murine mastocytoma P-815 cells: role of ether-linked phospholipids.

Journal of Lipid Research, 1990
The ethanolamine-containing glycerophospholipids, choline-containing glycerophospholipids, and phosphatidylinositol fractions are major sources of arachidonic acid in murine mastocytoma P-815 cloned cells.
S Yoshioka, S Nakashima, Y Okano, Y Nozawa   +3 more
doaj   +1 more source

Phospholipid (diacyl, alkylacyl, alkenylacyl) and fatty acyl chain composition in murine mastocytoma cells.

Journal of Lipid Research, 1985
The phospholipids from murine mastocytoma FMA3 and P-815 clone cells were quantitatively analyzed, and the major glycerophospholipids were examined for their fatty acyl chain distribution.
S Yoshioka, S Nakashima, Y Okano, H Hasegawa, A Ichiyama, Y Nozawa   +5 more
doaj   +1 more source

Metabolic Heavy Isotope Labeling to Study Glycerophospholipid Homeostasis of Cultured Cells

Bio-Protocol, 2017
Glycerophospholipids consist of a glycerophosphate backbone to which are esterified two acyl chains and a polar head group. The head group (e.g., choline, ethanolamine, serine or inositol) defines the glycerophospholipid class, while the acyl chains ...
Satu Hänninen, Pentti Somerharju, Martin Hermansson   +2 more
doaj   +1 more source