Results 151 to 160 of about 21,259 (271)

Molecular Adaptations and Sex‐Biased Regulatory Pathways in Multi‐Year Diapause of the Cabbage Beetle Colaphellus bowringi: A Duration‐Resolved Transcriptomic Analysis

Ecology and Evolution, Volume 16, Issue 11, November 2026.
This study presents the first multi‐duration, sex‐stratified transcriptomic analysis of prolonged diapause in Colaphellus bowringi, revealing that extended dormancy is maintained by coordinated metabolic suppression and sustained activation of cytoprotective pathways (e.g., glutathione metabolism, autophagy).
Lili Huang, Yan Ni, Xin Ye, Xiaona Liu, Fangsen Xue, Haimin He   +5 more
wiley   +1 more source

Aflatoxin B1 Exacerbates Ketogenic Diet‐Induced Hepatic Oxidative Stress and Glucose and Lipid Metabolic Disturbances in Mice

Food Frontiers, Volume 7, Issue 6, November 2026.
AFB1 exposure aggravates KD‐associated hepatic oxidative stress, inflammation, and glucose and lipid metabolic disturbances in mice. These effects are accompanied by dysregulation of AMPK, mTOR, and PPAR‐γ signaling and extensive hepatic metabolic reprogramming. ABSTRACT Aflatoxin B1 (AFB1) is a widespread mycotoxin with severe hepatotoxicity.
Xueyuan Hu, Zhenjun Sun, Xiaojing Wang, Shaochun Liu, ZhenBang Ye, Xueshu Han, Yang Ni, Linlin Hou, Yongping Chen, Huanqi Liu   +9 more
wiley   +1 more source

Salicylic Acid as a Food‐Derived Bioactive Constituent of Tiaoqi Daozhi Decoction: A Potential Functional Food Ingredient to Restoring Gut Barrier Function in Constipation‐Predominant IBS

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Tiaoqi Daozhi Decoction (TQDZD) is a classic formulation composed of eight medicine‐food homologous botanicals. UPLC‐MS/MS profiling identified 1962 non‐redundant compounds in its aqueous extract, predominantly phenolic acids and flavonoids, of which 107 metabolites were systemically bioavailable.
Min Duan, Lixia Huang, Yingyue Xu, Ya Huang, Xiaojun Yang   +4 more
wiley   +1 more source

Integrated Multi‐Omics Analysis of Polygonatum odoratum Polysaccharide in D‐Galactose‐Treated Mice Reveals Changes in Oxidative Stress Markers and Gut Microbiota

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
This study evaluated the effects of Polygonatum odoratum polysaccharide (POP) in D‐galactose‐treated mice using hippocampal histology, oxidative stress measurements, and integrated multi‐omics analyses. Results showed improved hippocampal histology and oxidative stress markers, accompanied by changes in gut bacterial composition, serum metabolites, and
Wenjian Li, Yan Huang, Wenfang Zhang, Shunxiang Li, Lisong Li   +4 more
wiley   +1 more source

Alpinia oxyphylla Miq.: Chemical Constituents, Neuroprotective and Metabolic Effects, and Translational Challenges—A Review of Preclinical Evidence

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Alpinia oxyphylla Miq. (AOM), a medicinal and edible resource, contains diphenylheptanoids, polysaccharides, flavonoids, terpenoids, and phenolic acids. These constituents exert multi‐target synergistic effects by modulating neuroinflammation, oxidative stress, and the PI3K/Akt pathway, thereby improving Alzheimer's disease, Parkinson's disease, and ...
Ziyan Yang, Hemei Yuan, Dengyou Nie, Jun Sheng, Titi Liu, Huanhuan Xu   +5 more
wiley   +1 more source

Matrix Vesicle‐Associated SMS2 as a Novel Mediator of Biomineralization

Journal of Extracellular Biology, Volume 5, Issue 11, November 2026.
ABSTRACT SGMS2, a gene encoding plasma membrane‐resident sphingomyelin synthase 2, SMS2, has emerged as an important determinant of skeletal ossification. Heterozygous SGMS2 variants are associated with a broad spectrum of bone phenotypes, ranging from rickets‐like deformities in childhood to early‐onset osteoporosis, implicating SMS2 in mineralization
Phillip T. Newton, Mathieu Y. Brunet, Jose G. Marchan‐Alvarez, Outi Mäkitie, Joost C. M. Holthuis   +4 more
wiley   +1 more source

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 11, November 2026.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

Identification of Potential Biomarkers for Ulcerative Colitis and Analysis of Immune Cell Infiltration: A Study Based on Data‐Independent Acquisition Proteomics and the GEO Public Database

PROTEOMICS – Clinical Applications, Volume 20, Issue 6, November 2026.
ABSTRACT Background Ulcerative colitis (UC) is a challenging inflammatory bowel disease characterized by chronic inflammation of the colon's mucosal layer. Despite advances in medical research, UC lacks definitive diagnostic tests and targeted treatments.
Shuai Wang, Hualiang Deng, Dajuan Sun
wiley   +1 more source

Hepatic Overexpression of Lysophospholipid Acyltransferase LPLAT14/MBOAT1 Ameliorates Mild Liver Injury During Early High‐Fat Diet Feeding

FASEB BioAdvances, Volume 8, Issue 11, November 2026.
Using an improved adenovirus vector, we investigated the effects of hepatic LPLAT14 overexpression on high‐fat diet (HFD)‐induced metabolic disorders and mild liver injury in mice. LPLAT14 selectively increased oleic acid (OA)‐containing phosphatidylserine (PS) species in the liver. This specific lipidomic remodeling attenuated mild liver injury during
Sho Hori, Kahori Shimizu, Taiga Kikuchi, Hajime Miyata, Hiroaki Hase, Hiroki Nakanishi, Hideo Shindou, Hiroyuki Mizuguchi   +7 more
wiley   +1 more source

Cellular membranes of the related fission yeast species differ in their dipole potential. [PDF]

Biophys Rep (N Y)
Rao BD, Oliferenko S.
europepmc   +1 more source