Results 131 to 140 of about 20,599 (278)

Optimized ¹³C‑TrEnDi Enhances the Sensitivity of Plasmenyl Ether Glycerophospholipids and Demonstrates Compatibility with Other Derivatization Strategies

The identification and quantitation of plasmalogen glycerophospholipids is challenging due to their isobaric overlap with plasmanyl ether-linked glycerophospholipids, susceptibility to acid degradation, and their typically low abundance in biological ...
Hillary Bourgaize (18274984), Christian A. Rosales (9755246), Peter J. Pallister (9755252), Jeffrey M. Manthorpe (1827226), Jeffrey C. Smith (642500), Joshua A. Roberts (9755249), Samuel W. J. Shields (9755243), Carlos R. Canez (4356742)   +7 more
core   +1 more source

Biosynthesis of ether and ester glycerophospholipids and the chemical structures of the precursors used.

, 2013
(A) Schematic overview of the biosynthesis of ether and ester glycerophospholipids. Note that 1-alkylglycerols such as HG (red box) may enter the pathway through phosphorylation to 1-alkylglycerol 3-phosphate by an alkylglycerol kinase. For abbreviations
Jonas Bergan (143033), Tore Skotland (464751), Tuulia Sylvänne (464752), Kirsten Sandvig (153014), Helena Simolin (464753), Kim Ekroos (464754)   +5 more
core   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, EarlyView.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Multi‐omics analyses reveal host–microbe interactions in atopic dermatitis and psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Atopic dermatitis (AD) and psoriasis (PSO) are chronic inflammatory skin diseases with complex host–microbe interactions. This study analysed skin samples from patients and healthy individuals using integrated microbial and transcriptomic profiling. Both diseases showed disrupted fungal–bacterial interactions and alterations in host immune responses ...
Ying Yang, Peter Olah, Alexander Salava, Jonathan Barker, Antti Lauerma, Björn Andersson, Nanna Fyhrquist, Bernhard Homey, Harri Alenius   +8 more
wiley   +1 more source

NAFPD exacerbation by hyperlipidemia combined with hyperuricemia: a pilot rat experiment in lipidomics

Frontiers in Nutrition
BackgroundHyperuricemia and non-alcoholic fatty pancreas disease (NAFPD) are prevalent metabolic diseases, but the relationship between them remains underexplored.MethodsEighteen Sprague–Dawley rats were randomly assigned to three groups: normal (CON ...
Jingyun Li, Jingyun Li, Yongjian Chen, Shilin Li, Guorong Lyu, Guorong Lyu, Furong Yan, Jiajing Guo, Jing Cheng, Yun Chen, Jiaojiao Lin, Yating Zeng   +11 more
doaj   +1 more source

Temperature, but not acidification, influences the growth and lipid profile of juvenile sand whiting, Sillago ciliata (Cuvier 1829)

Journal of Fish Biology, EarlyView.
Abstract Seafood provides an essential source of macro‐ and micronutrients for coastal communities worldwide. Climate change is a key threat to seafood security, altering the sizes, abundances, distributions, physiology and ecological interactions of fisheries species, and increasingly, there is evidence of impacts to seafood nutritional quality.
Tanika C. Shalders, Melissa Tan, Karina C. Hall, Melinda A. Coleman, Brendan Kelaher, Curtis Champion, Kirsten Benkendorff   +6 more
wiley   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Cationic amphiphilic drugs induce accumulation of cytolytic lysoglycerophospholipids in the lysosomes of cancer cells and block their recycling into common membrane glycerophospholipids

Lysosomes are acidic organelles responsible for lipid catabolism, and their func-tions can be disrupted by cationic amphiphilic drugs that neutralize lumenal pH and thereby inhibit most lysosomal hydrolases. These drugs can also induce lysosomal membrane
Nielsen, Inger Ødum, Giacobini, Jano Dicroce, Bilgin, Mesut, Dietrich, Tiina Naumanen, Maeda, Kenji, Jäättelä, Marja, Clemmensen, Knut Kristoffer Bundgaard, Fogde, Ditte Louise   +7 more
core   +1 more source

Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia

Oral Diseases, EarlyView.
ABSTRACT Background We assessed protein biomarkers expressed in oral leukoplakia (OL) that are associated with the risk of transformation into oral squamous cell carcinoma (OSCC). Methods Tissue sections of OL transforming into OSCC (leuko‐ca), the corresponding OSCC and OL that did not progress to OSCC (leuko‐nonca) were analyzed with global relative ...
Daniel Giglio, Divya Ganesh, Bishwa Prakash Bhattarai, Tine Merete Søland, Jonas Sundberg, Annika Thorsell, Jenny Öhman, Dipak Sapkota, Bengt Hasséus   +8 more
wiley   +1 more source

Comparative Genome‐Wide Association Studies of Metabolites and Grain‐Related Traits in Common Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT The metabolome is highly diverse and the closest layer to phenotype; therefore, it is commonly regarded as a bridge between the genome and phenome in plants. Here, we performed large‐scale metabolome analysis using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and 33 grain‐related traits in a diverse panel of natural accessions and
Guoguo Lv, Yanyan Liu, Bingyang Zhang, Ranran Shen, Maosong Yu, Yongyang Wu, Wanting Du, Xinru Yuan, Congwei Sun, Yan Yan, Wei Chen, Feng Chen   +11 more
wiley   +1 more source