Results 121 to 130 of about 21,259 (271)

Phosphatidylcholine with C26:0 moiety, a precursor of a diagnostic marker for X-ALD, is synthesized by LPLAT10/LPEAT2

Journal of Lipid Research
X-linked adrenoleukodystrophy (X-ALD) is a congenital metabolic disorder characterized mainly by inflammatory demyelination and adrenal insufficiency.
Kotaro Hama, Yuko Fujiwara, Koko Imai, Yoshio Kusakabe, Yasuhiro Hayashi, Shigeo Takashima, Shohei Azuma, Masaru Kondo, Atsushi Yamashita, Ryo Takita, Nobuyuki Shimozawa, Kazuaki Yokoyama   +11 more
doaj   +1 more source

Multi‐Omics Integration Reveals Metabolic Reprogramming and EMT‐Driven Metastasis in Triple‐Negative Breast Cancer

Cancer Science, EarlyView.
Integrated transcriptomic, metabolomic, and spatial proteomic profiling of TNBC tumors identifies a metastatic‐associated molecular landscape characterized by EMT activation, metabolic reprogramming, and tumor microenvironment (TME) remodeling. Multi‐omics integration reveals coordinated alterations in EMT signatures, amino acid metabolism, immune ...
Yuheng Pang, Yuefeng Shang, Wenjing Wang, Tong Liu, Xiaolong Zou   +4 more
wiley   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Insights into human cardiac lipid dynamics through comprehensive arteriovenous lipidomics

Journal of Lipid Research
Free fatty acids (FFAs) are the adult heart’s primary energy substrate, but human cardiac lipid exchange remains incompletely characterized. We assessed cardiac lipid import and export using arteriovenous lipidomics in a prospective observational study ...
Lee Bockus, Nadia Chamoun, Ahmad Kassar, Yaacoub Chahine, Romanos Haykal, Jason Li, Dennis Wang, Kevin O’Brien, Danijel Djukovic, Daniel Raftery, Zoltan Arany, Rong Tian, Nona Sotoodehnia, Nazem Akoum   +13 more
doaj   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

The Phospholipase A2 Superfamily in Health and Disease: From Lipid Signaling to Inflammation, Cancer, and Neurodegeneration

Journal of Lipid and Atherosclerosis
The phospholipase A2 (PLA2) superfamily comprises more than 50 enzymes that differ markedly in structure, catalytic mechanisms, and biological functions.
Mohammad Mamun Sikder, Sanzida Akter Labony   +1 more
doaj   +1 more source

Relevance of dietary glycerophospholipids and sphingolipids to human health

, 2015
Glycerophospholipids and sphingolipids participate in a variety of indispensable metabolic, neurological, and intracellular signaling processes. In this didactic paper we review the biological roles of phospholipids and try to unravel the precise nature ...
Fontecha, F. Javier, Castro-Gómez, Pilar, García-Serrano, Alba M., Garcia Serrano, A., VISIOLI, FRANCESCO, Fontecha, J., Castro Gómez, P   +6 more
core   +1 more source

Multi‐omics analyses reveal host–microbe interactions in atopic dermatitis and psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Atopic dermatitis (AD) and psoriasis (PSO) are chronic inflammatory skin diseases with complex host–microbe interactions. This study analysed skin samples from patients and healthy individuals using integrated microbial and transcriptomic profiling. Both diseases showed disrupted fungal–bacterial interactions and alterations in host immune responses ...
Ying Yang, Peter Olah, Alexander Salava, Jonathan Barker, Antti Lauerma, Björn Andersson, Nanna Fyhrquist, Bernhard Homey, Harri Alenius   +8 more
wiley   +1 more source

Tafazzin catalyzes transacylation and hydrolysis with inverse acyl specificities

Journal of Lipid Research
Tafazzin is a phospholipid-lysophospholipid acyltransferase that remodels fatty acids of mitochondrial phospholipids. To study the tafazzin mechanism, we expressed and purified the enzyme, measured its kinetics with different pairs of phosphatidylcholine
Michael Schlame, Yang Xu, Mindong Ren, Julio Lopes Sampaio, Daniel Levy   +4 more
doaj   +1 more source

Enzymatic fatty acid exchange in glycerophospholipids

, 2003
Lipases can be used to exchange fatty acids in the sn-1 position of glycerophospholipids and phospholipase A2 is useful for the corresponding exchange reaction in the sn-2 position. In both cases, the exchange can be done in a one-step acidolysis process
Adlercreutz, Patrick, Lyberg, Ann-Marie, Adlercreutz, Dietlind, Adlercreutz, Patrick,   +3 more
core   +1 more source