Results 11 to 20 of about 398,460 (354)
Glycine and glycine receptor signalling in non-neuronal cells [PDF]
Frontiers in Molecular Neuroscience, 2009 Glycine is an inhibitory neurotransmitter acting mainly in the caudal part of the central nervous system. Besides this neurotransmitter function, glycine has cytoprotective and modulatory effects in different non-neuronal cell types.
Jimmy Van Den Eynden +8 more
doaj +6 more sources
Orexin neurons receive glycinergic innervations. [PDF]
PLoS ONE, 2011 Glycine, a nonessential amino-acid that acts as an inhibitory neurotransmitter in the central nervous system, is currently used as a dietary supplement to improve the quality of sleep, but its mechanism of action is poorly understood.
Mari Hondo +4 more
doaj +1 more source
New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms [PDF]
, 2013 Background: Hyperekplexia mutations have provided much information about glycine receptor structure and function. Results: Weidentified and characterized nine new mutations.
Alfred P. Born +89 more
core +1 more source
Actions of N-arachidonyl-glycine in a rat inflammatory pain model
Molecular Pain, 2007 Background While cannabinoid receptor agonists have analgesic activity in inflammatory pain states they produce a range of side effects. Recently, it has been demonstrated that the arachidonic acid-amino acid conjugate, N-arachidonyl-glycine (NA-glycine)
Vaughan Christopher W +2 more
doaj +1 more source
Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]
, 2007 Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D. +3 more
core +2 more sources
A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue [PDF]
, 2008 Cys-loop receptor binding sites characteristically contain many aromatic amino acids. In nicotinic ACh and 5-HT3 receptors, a Trp residue forms a cation-{pi} interaction with the agonist, whereas in GABAA receptors, a Tyr performs this role.
Dougherty, Dennis A. +6 more
core +2 more sources
Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials [PDF]
, 2017 BACKGROUND: Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function.
Hwei-Hsien Chen +5 more
core +1 more source
Journal of Pharmacological Sciences, 2010 Recent evidence indicates that strychnine-sensitive glycine receptors are located in upper brain regions including the hippocampus. Because of excitatory effects of glycine via facilitation of NMDA-receptor function, however, the net effects of increased
Mitsuo Tanabe, Azusa Nitta, Hideki Ono
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 SLC6A20A is a proline and glycine transporter known to regulate glycine homeostasis and NMDA receptor (NMDAR) function in the brain. A previous study found increases in ambient glycine levels and NMDA receptor-mediated synaptic transmission in the brains
Junhyung Kim +6 more
doaj +1 more source
Glycine is able to induce both a motility speed in- and decrease during zebrafish neuronal migration
Communicative & Integrative Biology, 2018 Various neurotransmitters influence neuronal migration in the developing zebrafish hindbrain. Migrating tegmental hindbrain nuclei neurons (THNs) are governed by depolarizing neurotransmitters (acetylcholine and glutamate), and glycine. In mature neurons,
Ulrike Theisen +4 more
doaj +1 more source