Results 31 to 40 of about 4,293 (152)

Structural glycobiology and human health

, 2010
The glycans (carbohydrates) form a diverse group of biomolecules which play active parts in most physiological processes. The field of structural glycobiology concerns the structures of the glycans themselves, the proteins which interact with them and ...
Corfield, A, Mulloy, B, Barbara Mulloy, Anthony P. Corfield   +3 more
core   +1 more source

Cancer-selective induction of apotosis by leczyme

Frontiers in Oncology, 2014
Sialic acid-binding lectin (SBL) is a multifunctional protein that is isolated from oocytes of Rana catesbeiana. It has both lectin and ribonuclease (enzyme) properties, and therefore is called leczyme.
Takeo eTatsuta, Sigeki eSugawara, Kohta eTakahashi, Yukiko eOgawa, Masahiro eHosono, Kazuo eNitta   +5 more
doaj   +1 more source

The Glycobiology of Pulmonary Arterial Hypertension

Metabolites, 2022
Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease of complex etiology. Cases of PAH that do not receive therapy after diagnosis have a low survival rate.
Shia Vang, Phillip Cochran, Julio Sebastian Domingo, Stefanie Krick, Jarrod Wesley Barnes   +4 more
doaj   +1 more source

Enzyme‐Linked Cycloaddition Assay (ELCA) for Rapid, Ultra‐Sensitive Monitoring of Secreted Sialoglycoproteins

Advanced Science, EarlyView.
Secreted glycoproteins report on cellular state faster than the cell surface, yet remain hard to measure. The Enzyme‐Linked Cycloaddition Assay (ELCA) combines metabolic azide labeling with click chemistry in an ELISA‐like microplate format, resolving sialylation changes within minutes for 1‐2 EUR per sample.
Jon Lundstrøm, Jingmei Yang, Daniel Bojar   +2 more
wiley   +1 more source

Galectin-4 contributes to the maintenance of expression and activation of multiple receptor-type kinases involved in peritoneal metastasis

Scientific Reports
Owing to the lack of effective therapeutic strategies, peritoneal metastasis of metastatic and recurrent gastric cancers is associated with poor prognosis.
Hiroko Ideo, Miwa Umebayashi, Yoshio Takada, Akiko Tsuchida   +3 more
doaj   +1 more source

Glycan Profiling by Sequencing to Uncover Multicellular Communication: Launching Glycobiology in Single Cells and Microbiomes

Frontiers in Cell and Developmental Biology, 2022
Glycans are essential building blocks of life that are located at the outermost surface of all cells from mammals to bacteria and even viruses. Cell surface glycans mediate multicellular communication in diverse biological processes and are useful as ...
Lalhaba Oinam, Hiroaki Tateno
doaj   +1 more source

Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy [PDF]

, 2021
Cancer immunotherapy has revolutionized treatment and led to an unprecedented wave of immuno-oncology research during the past two decades. In 2018, two pioneer immunotherapy innovators, Tasuku Honjo and James P. Allison, were awarded the Nobel Prize for
Baghdassarian, Hratch, Nathan E. Lewis, Chiang, Austin, Chiang, Austin W.T., Kuo, Chih-Chung, Chenguang Liang, Lewis, Nathan, Kellman, Benjamin P., Kellman, Benjamin, Masson, Helen O., Kuo, Chih Chung, Austin W. T. Chiang, Baghdassarian, Hratch M., Masson, Helen, Chih-Chung Kuo, Bao, Bokan, Liang, Chenguang, Lewis, Nathan E., Sorrentino, James T., Hratch M. Baghdassarian, James T. Sorrentino, Helen O. Masson, Benjamin P. Kellman, Bokan Bao, Sorrentino, James   +24 more
core   +1 more source

Glycobiology of Cancer: Sugar Drives the Show

, 2022
Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which ...
Mendonça Previato, Lucia, Kelli Monteiro da Costa, Freire-de-Lima, Celio Geraldo, dos Reis, Jhenifer Santos, Previato, Jose Osvaldo, Leonardo Marques da Fonseca, Stefani Ingrid Martins do Nascimento, da Fonseca, Leonardo Marques, Pedro Marçal Barcelos, Martins do Nascimento, Stefani Ingrid, Freire-de-Lima, Leonardo, Rodrigues da Costa Santos, Marcos André, Lucia Mendonça Previato, Mendonça, Daniella Pereira, Jose Osvaldo Previato, Correia de Lima, Rafaela Gomes, Alexandre Morrot, Marcos André Rodrigues da Costa Santos, Barcelos, Pedro Marçal, Daniella Pereira Mendonça, Jhenifer Santos dos Reis, Leonardo Freire-de-Lima, Rafaela Gomes Correia de Lima, da Costa, Kelli Monteiro, Morrot, Alexandre, Celio Geraldo Freire-de-Lima, Reis, Jhenifer Santos dos, Nascimento, Stefani Ingrid Martins do, Lima, Celio Geraldo Freire de, Lima, Leonardo Freire de, Santos, Marcos André Rodrigues da Costa, Costa, Kelli Monteiro da, Fonseca, Leonardo Marques da, Lima, Rafaela Gomes Correia de, Previato, Lucia Mendonça   +34 more
core   +1 more source

GH172 Difructose Dianhydride I Synthase: A Two‐Stepped Journey via Glycosylation and Cyclization Using QM/MM Metadynamics

Chemistry – A European Journal, EarlyView.
Unlocking the chemistry of caramel by simulations and experimental validation. αFFase1${\alpha }\rm{FFase1}$ converts inulobiose into difructose dianhydride I, one component of caramel, through two steps: a rate‐limiting glycosylation (with a rare sugar ring flip) followed by a cyclization step, guided by residues E85, K147, and N226.
Santiago Alonso‐Gil, Bruno Di Geronimo, Toma Kashima, Akihiro Ishiwata, Katsunori Tanaka, Kiyotaka Fujita, Shinya Fushinobu, Pedro A. Sánchez‐Murcia   +7 more
wiley   +1 more source

Intracellular Delivery of Hydrophilic Glycans Using Superchaotropic Clusters

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Superchaotropic boron clusters are demonstrated to deliver hydrophilic glycans directly into mammalian cells, removing the need for acetylation and cytotoxic solvents such as DMSO. Azido glycans for metabolic oligosaccharide engineering, and trehalose, were delivered and the successful azido‐labelling of glycoproteins, cell surface glycans, and ...
Qiao Tang, Alexandru Ilie, Matthew I. Gibson   +2 more
wiley   +2 more sources